Xanthine Oxidase Inhibitors

All categories
Name
Xanthine Oxidase Inhibitors
Accession Number
DBCAT002773  (DBCAT002774, DBCAT002775, DBCAT003814)
Description

An xanthine oxidase inhibitor is any substance that inhibits the activity of xanthine oxidase, an enzyme involved in purine metabolism. In humans, inhibition of xanthine oxidase reduces the production of uric acid, and several medications that inhibit xanthine oxidase are indicated for treatment of hyperuricemia and related medical conditions including gout.

Drugs
DrugDrug Description
AllopurinolA xanthine oxidase inhibitor used to reduce urinary and serum uric acid concentrations in patients with gout, recurrent calcium oxalate calculi, and various malignancies.
FebuxostatA xanthine oxidase inhibitor used for the management of chronic hyperuricemia in adults with gout who have an inadequate response or intolerance to allopurinol.
OxypurinolIntended for the treatment of congestive heart failure and hyperuricemia.
Drugs & Drug Targets
DrugTargetType
AllopurinolXanthine dehydrogenase/oxidasetarget
AllopurinolOrganic anion transporter 3transporter
AllopurinolSolute carrier family 22 member 7transporter
AllopurinolAldehyde oxidaseenzyme
AllopurinolXanthine dehydrogenase/oxidaseenzyme
AllopurinolBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
AllopurinolSolute carrier family 22 member 2transporter
AllopurinolCytochrome P450 1A2enzyme
FebuxostatAlbumincarrier
FebuxostatXanthine dehydrogenase/oxidasetarget
FebuxostatUDP-glucuronosyltransferase 1A1enzyme
FebuxostatUDP-glucuronosyltransferase 1A3enzyme
FebuxostatUDP-glucuronosyltransferase 1A9enzyme
FebuxostatUDP-glucuronosyltransferase 2B7enzyme
FebuxostatCytochrome P450 1A2enzyme
FebuxostatCytochrome P450 2C8enzyme
FebuxostatCytochrome P450 2C9enzyme
FebuxostatBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
OxypurinolXanthine dehydrogenase/oxidasetarget