Coccidioidomycosis (DBCOND0000138)

Identifiers

Synonyms

Valley Fever / Coccidioides infections / Coccidioidomycosis, unspecified / Coccidioides immitis infection / San Joaquin valley fever / Coccidioidomycosis (disorder) / Acute coccidioidomycosis (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amphotericin B	An antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis.	Ergosteroltarget
Fluconazole	A triazole antifungal used to treat various fungal infections including candidiasis.	Cytochrome P450 3A4enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme ATP-dependent translocase ABCB1transporter Lanosterol 14-alpha demethylasetarget Cytochrome P450 3A5enzyme
Ketoconazole	A broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.	Cytochrome P450 3A4enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 3A5enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C8enzyme Cytochrome P450 1A1enzyme Cytochrome P450 2D6enzyme Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 1B1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Lanosterol 14-alpha demethylasetarget Androgen receptortarget Steroid 17-alpha-hydroxylase/17,20 lyasetarget Steroid 21-hydroxylasetarget Voltage-gated inwardly rectifying potassium channel KCNH2target Nuclear receptor subfamily 1 group I member 2target Nuclear receptor subfamily 1 group I member 3target UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 2B7enzyme Solute carrier organic anion transporter family member 1B1transporter Cytochrome P450 4F12enzyme Cytochrome P450 4F2enzyme Albumincarrier Sex hormone-binding globulincarrier Aromataseenzyme UDP-glucuronosyltransferase 1A7enzyme Lanosterol 14-alpha demethylasetarget
Posaconazole	A triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.	Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Lanosterol 14-alpha demethylasetarget
Voriconazole	A triazole compound used to treat fungal infections.	Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C9enzyme Flavin-containing monooxygenase 1enzyme Flavin-containing monooxygenase 3enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Prostaglandin G/H synthase 1enzyme Lanosterol 14-alpha demethylasetarget Cytochrome P450 2B6enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04809649	SUBA-Itraconazole Therapy for Coccidioidomycosis Refractory or Intolerant to Fluconazole	Itraconazole	treatment	2	withdrawn
NCT03618992	Improving the Appearance of Skin and Hair in Patients Undergoing Valley Fever Treatment	No drug interventions	treatment	Not Available	terminated
NCT02190266	Pathogenesis and Genetics of Disseminated or Refractory Coccidioidomycosis	No drug interventions	Not Available	Not Available	recruiting
NCT06523998	A Study on Rare Dermatological Infections Conducted at Three Major Reference Hospitals in Costa Rica.	No drug interventions	Not Available	Not Available	completed
NCT00002325	A Study of Fluconazole in the Prevention of Fungal Infections in HIV-Infected Patients Living in Areas Where Fungal Infections Are Common	Fluconazole	treatment	Not Available	completed
NCT03059992	Study to Evaluate the Efficacy and Safety of Ibrexafungerp in Patients With Fungal Diseases That Are Refractory to or Intolerant of Standard Antifungal Treatment	Ibrexafungerp	treatment	3	completed
NCT00423267	POS vs FLU for First Line Treatment of Coccidioidomycosis (Study P04558Am1)(COMPLETED)	Fluconazole Posaconazole	treatment	3	completed
NCT04208321	Safety and Pharmacokinetics of VT-1598	VT-1598	treatment	1	completed
NCT00796809	Risk of Coccidioidomycosis in Patients Receiving Anti-TNF and Other Biologic Agents for an Inflammatory Arthritis	No drug interventions	Not Available	Not Available	completed
NCT03908632	An Observational Study to Assess the Prevalence and Outcomes of Primary Pulmonary Coccidioidomycosis in Persons Aged > / = 14 Years Presenting With Community Acquired Pneumonia (CAP) in Endemic Areas (SAnds-PPC)	No drug interventions	Not Available	Not Available	completed
NCT02908334	Sertraline in Addition to Standard of Care Treatment for Coccidioidomycosis	Sertraline	treatment	2	withdrawn
NCT00614666	Safety and PK of Nikkomycin Z for Coccidioides Pneumonia Treatment	Nikkomycin Z	treatment	1 / 2	terminated
NCT02663674	Efficacy Study of Fluconazole to Treat Coccidioidomycosis Pneumonia (Valley Fever)	Fluconazole	treatment	4	terminated
NCT00690092	A Multi-center Study of Spherule-Derived Coccidioidin	No drug interventions	diagnostic	3	completed