Meningitis, Cryptococcal (DBCOND0000139)

Identifiers

Synonyms
Cryptococcal Meningitis / Meningitis cryptococcal / Cerebral cryptococcosis / Cryptococcal meningitis (disorder) / Meningitis torula / Cryptococcus neoformans meningitis

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Amphotericin B
An antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis.
Fluconazole
A triazole antifungal used to treat various fungal infections including candidiasis.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT00002077
An Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal MeningitistreatmentNot Availablecompleted
NCT00002305
A Comparison of Fluconazole and Amphotericin B in the Treatment of Cryptococcal MeningitistreatmentNot Availablecompleted
NCT00002076
Pilot Study of Oral Fluconazole in the Treatment of Acute Cryptococcal MeningitistreatmentNot Availablecompleted
NCT00000776
Dexamethasone in Cryptococcal Meningitistreatment2completed
NCT00002294
A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients With AIDStreatmentNot Availablecompleted
NCT00002040
Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal MeningitistreatmentNot Availablecompleted
NCT00000677
SCH 39304 as Therapy for Acute Cryptococcal Meningitis in HIV-Infected Patients Followed by Maintenance TherapyNo drug interventionstreatment1completed
NCT00002075
Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal MeningitistreatmentNot Availablecompleted
NCT02334670
Vietnam Cryptococcal Retention in Care Study Version 1.0Not AvailableNot Availableunknown_status
NCT00002306
A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients Who Have Not Had Success With Amphotericin BtreatmentNot Availablecompleted
NCT00002113
A Pilot Study of Fluconazole Plus Flucytosine for the Treatment of AIDS Patients With Acute Cryptococcal Meningitis.treatmentNot Availablecompleted
NCT00002019
Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency SyndrometreatmentNot Availablecompleted
NCT00001017
Comparison of Fluconazole and Amphotericin B in the Treatment of Brain Infections in Patients With AIDStreatment3completed
NCT00002316
The Safety and Effectiveness of RMP-7 Plus Amphotericin B in Patients With HIV and Cryptococcal Meningitistreatment1completed
NCT00000639
A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal MeningitistreatmentNot Availablecompleted
NCT00002074
Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Maintenance Treatment for the Prevention of Relapse of Cryptococcal Meningitis in Patients With Acquired Immunodeficiency SyndrometreatmentNot Availablecompleted
NCT00012467
Safety and Antifungal Activity of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Cryptococcal Meningitistreatment2completed
NCT00002068
A Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal MeningitistreatmentNot Availablecompleted
NCT00000708
Multi-center Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal MeningitistreatmentNot Availablecompleted
NCT03226379
Driving Reduced AIDS-associated Meningo-encephalitis MortalityNo drug interventionshealth_services_researchNot Availablecompleted
NCT04031833
Encochleated Oral Amphotericin for Cryptococcal Meningitis Trial (EnACT)treatment1 / 2completed
NCT02624453
Pre-Antiretroviral Therapy (ART) Cryptococcal Antigen Screening in AIDSscreeningNot Availableunknown_status
NCT02686853
Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitistreatment4unknown_status
NCT00830856
Early Versus Delayed Antiretroviral Therapy (ART) in the Treatment of Cryptococcal Meningitis in AfricatreatmentNot Availablecompleted
NCT01075152
Cryptococcal Optimal ART Timing Trialtreatment4completed
NCT00145249
Amphotericin Alone or in Combination With Fluconazole for AIDS-Associated Meningitistreatment2completed
NCT05685641
Point of Care Tests to Identify Opportunistic Infections in Advanced HIV Patients in Mexico CityNo drug interventionsdiagnosticNot Availablenot_yet_recruiting
NCT05471063
Clinical Study of ABCD in the Treatment of Cryptococcal MeningitistreatmentNot Availableunknown_status
NCT00324025
Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDStreatment2terminated
NCT02136030
Liposomal Amphotericin B for the Treatment of Cryptococcal MeningitistreatmentNot Availableunknown_status
NCT01589289
Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRCNo drug interventionsdiagnostic3completed
NCT00976040
Optimal Time to Start Antiretroviral Therapy in HIV-infected Adults With Cryptococcal MeningitisNo drug interventionstreatment4completed
NCT02434172
CryptoART Study: Decreasing Mortality Associated With Initiation of Antiretroviral Therapy in Sub-Saharan AfricaNo drug interventionsNot AvailableNot Availablecompleted
NCT06414512
Optimizing the Dose of Flucytosine for the Treatment of Cryptococcal Meningitistreatment2recruiting
NCT00885703
High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individualstreatment1 / 2completed
NCT04140461
AmB Dose for Cryptococcal Meningitistreatment3unknown_status
NCT00847678
Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDStreatment2terminated
NCT03267407
Vietnam Cryptococcal Retention in Care Study - Version 2.1No drug interventionsNot AvailableNot Availableunknown_status
NCT05541107
Encochleated Oral Amphotericin for Cryptococcal Meningitis Trial 3treatment3not_yet_recruiting
NCT01802385
Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitistreatment3completed
NCT00001352
Fungal Infection SusceptibilityNo drug interventionsNot AvailableNot Availablerecruiting
NCT04532463
Clinical Effectiveness and Safety of Amphotericin B With Flucytosine-Fluconazole Therapy for Cryptococcal MeningitisNot AvailableNot Availablecompleted
NCT01715922
Study Evaluating Efficiency and Tolerance of High-dose Fluconazole Associated With Flucytosine as Induction Therapy for Cryptococcal Meningitis Associated With HIV in Sub-saharan Africatreatment2 / 3unknown_status
NCT02098525
Clinical Outcomes of Cryptococcal Meningitis Among HIV-infected Patients in the Era of Antiretroviral TherapyNo drug interventionsNot AvailableNot Availablecompleted
NCT03945448
Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemiaprevention2 / 3recruiting
NCT06178627
Amphotericin B for Non-HIV Cryptococcal Meningitis Patientstreatment4enrolling_by_invitation
NCT02955862
Vietnam Cryptococcal Retention in Care Study (CRICS) Federal Financial ReportNo drug interventionsscreening1completed
NCT04296292
The Lived Experience of Participants in an African Randomised TrialNo drug interventionsNot AvailableNot Availablecompleted
NCT04072640
Three Induction Treatments on Cryptococcal Meningitistreatment0unknown_status
NCT01535469
Operational Research for Cryptococcal Antigen Screeningprevention4completed
NCT00867269
Etiology, Pathogenesis, and Natural History of Idiopathic CD4+ LymphocytopeniaNo drug interventionsNot AvailableNot Availablerecruiting