Q Fever (DBCOND0000418)

Identifiers

Synonyms

Q fever / Infection due to Coxiella burnetii / Q-fever / Q fever (disorder) / Nine-mile fever / Coxiella burnetii infection

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Hydroxychloroquine	An antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic drug (DMARD) indicated for treatment of rheumatoid arthritis and lupus erythematosus.	DNAtarget Toll-like receptor 7target Toll-like receptor 9target Cytochrome P450 2D6enzyme ATP-dependent translocase ABCB1transporter Albumincarrier alpha1-acid glycoproteincarrier Cytochrome P450 3A4enzyme Solute carrier organic anion transporter family member 1A2transporter Angiotensin-converting enzyme 2target Cytochrome P450 2C8enzyme
Minocycline	A tetracycline analog used to treat a wide variety of infections in the body.	30S ribosomal protein S4target 30S ribosomal protein S9target 16S ribosomal RNAtarget Interleukin-1 betatarget Polyunsaturated fatty acid 5-lipoxygenasetarget Matrix metalloproteinase-9target Vascular endothelial growth factor A, long formtarget Caspase-1target Caspase-3target Cytochrome ctarget Solute carrier family 22 member 6transporter Solute carrier family 22 member 7transporter Outer membrane protein Ftransporter Outer membrane porin Ctransporter Mitogen-activated Protein Kinasestarget Nitric oxide synthase, inducibletarget
Tetracycline	An antibiotic used to treat a wide variety of susceptible infections.	16S ribosomal RNAtarget Major prion proteintarget Albumincarrier Cytochrome P450 3A4enzyme Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier family 22 member 7transporter 30S ribosomal protein S3target 30S ribosomal protein S8target 30S ribosomal protein S19target 30S ribosomal protein S14target 30S ribosomal protein S7target Multidrug translocase MdfAtarget Protein-arginine deiminase type-4target Solute carrier organic anion transporter family member 2B1transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01095328	A Screening Strategy for Q Fever Among Pregnant Women	No drug interventions	screening	Not Available	unknown_status
NCT02822807	Q Fever and Auto-immunity	No drug interventions	other	Not Available	completed
NCT01318356	The Qure Study: Q-fever Fatigue Syndrome - Response to Treatment	Doxycycline Tetracycline	treatment	4	completed
NCT03334019	Prevalence and Risk Factors for Coxiella Burnetii Seropositivity (Q Fever) Among Adults in Western France	No drug interventions	Not Available	Not Available	unknown_status
NCT02898402	Study on Seroprevalence and Risk Factors of Coxiella Burnetii (Q Fever) in the South of Reunion Island	No drug interventions	Not Available	Not Available	completed
NCT00584454	Safety Evaluation of a Q-fever Vaccine, NDBR 105	No drug interventions	prevention	2	completed
NCT02092142	Safety and Immunogenicity of Q Fever Vaccine	No drug interventions	prevention	2	withdrawn
NCT01450501	Chronic Q-fever in Patients With an Abdominal Aortic Disease (QAAD-study)	No drug interventions	Not Available	Not Available	unknown_status