Hyperemesis Gravidarum (DBCOND0001432)

Identifiers

Synonyms

Hyperemesis gravidarum / Excessive vomiting in pregnancy / Excess vomiting in pregnancy / Excessive vomiting in pregnancy (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Cocarboxylase	The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.	Acetolactate synthase, catabolictarget Pyruvate dehydrogenase E1 componenttarget Pyruvate synthasetarget Indole-3-pyruvate decarboxylasetarget N(2)-(2-carboxyethyl)arginine synthasetarget Transketolase 1target RNAtarget Benzoylformate decarboxylaseenzyme Pyruvate oxidaseenzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06615843	Randomized Study of a Dematerialized Management for Post-Emergency Gynecological Follow-Up	No drug interventions	supportive_care	Not Available	not_yet_recruiting
NCT05175079	Acupressure in Hyperemesis Gravidarum	No drug interventions	prevention	Not Available	completed
NCT00795561	Management of Nausea and Vomiting of Pregnancy	No drug interventions	treatment	Not Available	completed
NCT04785911	Use of the Modified PUQE Score on Admitted Cases of Hyperemesis Gravidarum (HG) to Guide Response to Treatment	Histamine	Not Available	Not Available	completed
NCT02619188	Nutritional Markers in Normal and Hyperemesis Pregnancies	No drug interventions	Not Available	Not Available	unknown_status
NCT06442813	Effects Of Emotional Freedom Technique and Hypermesis Gravidarum	No drug interventions	prevention	Not Available	not_yet_recruiting
NCT06266819	The Effect of Mint Flavored Chewing Gum on Hyperemesis Gravidarum Nausea Vomiting Severity, Coping With Stress and Anxiety Level in Pregnants With Hyperemesis Gravidarum	No drug interventions	prevention	Not Available	recruiting
NCT02163434	Comparison of Gabapentin and Metoclopramide for Treating Hyperemesis Gravidarum	Gabapentin Metoclopramide	treatment	2	completed
NCT04284696	Chewing Gum Containing Vitamin-c to Treat Emesis Gravidarum	No drug interventions	treatment	Not Available	completed
NCT01836835	Pregnancy Specific Nausea Questionnaire (PUQE) Translated and Tested in Norwegian	No drug interventions	Not Available	Not Available	completed
NCT04719286	MinSafeStart - Decision Aid Tool for Better Treatment of Nausea and Vomiting During Pregnancy	No drug interventions	other	Not Available	completed
NCT05446025	The Levels of the Orexin, Galanin and aMSH and CART in Patients With Hyperemesis Gravidarum	No drug interventions	Not Available	Not Available	completed
NCT00293644	Pre-emptive Treatment of Severe Nausea and Vomiting of Pregnancy	Doxylamine Pyridoxine	prevention	3	completed
NCT03950167	Gallbladder Functions & Serum Cholecystokinin Levels in Women Diagnosed With Hyperemesis Gravidarum	No drug interventions	Not Available	Not Available	completed
NCT04828967	Use of Hypnosis in Hyperemesis Gravidarum	No drug interventions	treatment	Not Available	completed
NCT05098067	Capsaicin Cream as an Adjunctive Therapy for Nausea and Vomiting of Pregnancy	Capsaicin Metoclopramide Ondansetron	treatment	2	completed
NCT01559012	Transdermal Clonidine in the Treatment of Severe Hyperemesis Gravidarum	Clonidine	treatment	3	completed
NCT02300155	Improving Multivitamin Supplementation to Pregnant Women	Ascorbic acid Beta carotene Calcium carbonate Cholecalciferol Cupric oxide Cyanocobalamin Ferrous fumarate Ferrous sulfate anhydrous Folic acid Magnesium oxide Nicotinamide Pantothenic acid Potassium Iodide Pyridoxine Riboflavin Thiamine Vitamin A Zinc oxide Zinc sulfate alpha-Tocopherol acetate	treatment	4	completed
NCT02830321	The Association of Helicobacter Pylori in the Pathogenesis of Hyperemesis Gravidarum in Pregnant Women	No drug interventions	Not Available	Not Available	completed
NCT06245811	Inflammation Markers in Hyperemesis Gravidarum	No drug interventions	Not Available	Not Available	completed
NCT03127293	Hyperemesis Gravidarum and Osteoporosis	No drug interventions	Not Available	Not Available	completed
NCT06581796	Pepsinogen-1 Serum Levels in Hyperemesis Gravidarum	No drug interventions	Not Available	Not Available	recruiting
NCT02862496	Bone Health in Hyperemesis Gravidarum	No drug interventions	Not Available	Not Available	unknown_status
NCT05452174	Endeavor to Stop Nausea/Vomiting Associated With Pregnancy (E-SNAP)	Mirtazapine	treatment	1 / 2	terminated
NCT02541682	Assessment of the Relationship Between Affective Temperament and the Severity of Nausea and Vomiting in Early Pregnancy	No drug interventions	diagnostic	Not Available	completed
NCT05829473	The Effect of Guided Imagery and Diaphragmatic Breathing Exercise in Pregnant Women With Hyperemesis Gravidarum	No drug interventions	supportive_care	Not Available	not_yet_recruiting
NCT03785691	Validating the Effect og Ondansetron and Mirtazapine in Treating Hyperemesis Gravidarum	Mirtazapine Ondansetron	treatment	2	terminated
NCT00861523	Does Thiamine Help Vomiting and Nausea in Pregnancy?	Promethazine Thiamine	treatment	3	terminated