Hypopituitarism (DBCOND0009184)

Identifiers

Synonyms

Hypopituitalism / Pituitary insufficiency / Hypopituitarism (disorder) / Insufficiency pituitary / Isolated deficiency of pituitary hormone (disorder) / Idiopathic growth hormone deficiency (disorder) / Isolated gonadotropin deficiency (disorder) / Hypogonadotropic Hypogonadism / Hypogonadotropic hypogonadism (disorder) / Secondary hypogonadism / Hypogonadotrophic hypogonadism / Isolated lutropin deficiency (disorder) / Panhypopituitarism / Panhypopituitarism (disorder) / Postpartum Hypopituitarism / Sheehan's syndrome (disorder) / Postpartum hypopituitarism (disorder) / Sheehan's syndrome / Pituitary cachexia (disorder) / Olfacto genital dysplasia / De Morsier-Kallman's syndrome / Kallman's syndrome / Hypogonadism with anosmia (disorder) / Kallmann's syndrome / Kallmann Syndrome / Asexual dwarfism (disorder) / Pituitary dwarfism / Pituitary dwarfism (disorder) / Dwarfism, Pituitary

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Somatotropin	A recombinant human growth hormone used as replacement therapy in various conditions of growth failure, growth hormone deficiency, and weakness in children and adults.	Growth hormone receptortarget Prolactin receptortarget Cytochrome P450 1A2enzyme Cytochrome P450 2C19enzyme ATP-dependent translocase ABCB1transporter
Testosterone phenylpropionate	A steroid indicated for testosterone replacement therapy in sterilization, missing testicle, hypopituitarism, and osteoporosis.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00572390	Oestrogen Withdrawal in Hypopituitary Women	No drug interventions	basic_science	Not Available	completed
NCT00133354	Arimidex Multicenter Trial in Growth Hormone (GH) Deficient Boys	Anastrozole Somatotropin	Not Available	2 / 3	completed
NCT06326853	Neuroendocrine Mechanisms in Adiposity: An Integrated Approach to the Characterization of Potential Pharmacological Novel Targets Based on Experimental and Clinical Models	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT06014398	Improving Survivorship and Health-related Quality of Life in Patients With Primary Brain Tumours	No drug interventions	diagnostic	Not Available	not_yet_recruiting
NCT00080483	Testosterone and Growth Hormone for Bone Loss in Men	Somatotropin Testosterone	treatment	2	completed
NCT01574859	Central Hypothyroidism and Cardiovascular Risk	No drug interventions	Not Available	Not Available	completed
NCT00851942	Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test	Tetracosactide	diagnostic	4	completed
NCT01088399	A Prospective Observational Study of Effect of Somatropin on Growth Hormone Deficient Adults	Somatotropin	Not Available	Not Available	completed
NCT05206149	Stimulation Test With Intranasal Glucagon for Corticotroph, Somatotroph and Antidiuretic Axes	Glucagon	diagnostic	4	completed
NCT00504218	Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors and Hematopoietic Stem Cell Transplant Recipients	No drug interventions	Not Available	Not Available	terminated
NCT00490191	Comparison of Two Growth Hormone Dosing Methods in Adults With Growth Hormone Deficiency	Somatotropin	treatment	4	completed
NCT05990491	Pituitary Function After Recovery From Septic Shock Among ICU Survivors	No drug interventions	Not Available	Not Available	recruiting
NCT04121780	Growth Hormone Replacement Therapy for Retried Professional Football Players	Somatotropin	treatment	2	recruiting
NCT00507104	Pituitary Functions After Traumatic Brain Injury (TBI) and/or Subarachnoid Hemorrhage (SAH)	No drug interventions	Not Available	Not Available	completed
NCT00666068	Effects of Corticotropin Releasing Hormone (CRH) on the Sleep in Patients With Hypopituitarism	No drug interventions	basic_science	Not Available	completed
NCT02360046	The Influence of Different Hydrocortisone Replacement Doses on the Partitioning and Flexibility of Ectopic Lipids in Patients With Corticotropic Hypopituitarism	Hydrocortisone	treatment	Not Available	terminated
NCT02782208	Lipolytic Effects of GH in Hypopituitary Patients in Vivo	Acipimox	basic_science	Not Available	completed
NCT01666964	Hormone Deficiency After Brain Injury During Combat	No drug interventions	Not Available	Not Available	unknown_status
NCT04897802	Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)	Exenatide	diagnostic	4	recruiting
NCT00139945	Ghrelin, Growth Hormone and Cortisol Interaction in Growth Hormone Deficient Patients	Lenomorelin	treatment	Not Available	completed
NCT01009905	An Observational Study (Registry) Assessing Treatment Outcomes and Safety for Children and Adults Who Are Prescribed Norditropin® (Human Growth Hormone)	Somatotropin	Not Available	Not Available	completed
NCT01007071	Effects of Growth Hormone on Cognition and Cerebral Metabolism in Adults With Growth Hormone Deficiency	L-Acetylleucine Somatotropin	treatment	3	completed
NCT00962559	Hypopituitarism After Aneurismal Subarachnoid Hemorrhage	No drug interventions	Not Available	Not Available	completed
NCT00462475	Effect of 5 Years of GH Replacement on Atherosclerosis	Somatotropin	Not Available	Not Available	completed
NCT01028742	Posttraumatic Hypopituitarism - Incidence, Predictors and Test Validity	No drug interventions	Not Available	Not Available	completed
NCT00140413	Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve Hypoplasia	Somatotropin	treatment	4	completed
NCT01209416	The Effect of Pharmacological Antilipolysis on the Metabolic Effects of Ghrelin	Acipimox Lenomorelin	basic_science	Not Available	completed
NCT04902235	Identification and Clinical Relevance of an Oxytocin Deficient State (CRH Study)	No drug interventions	diagnostic	4	completed
NCT02871986	Pubertal Induction in Individuals With Hypogonadism	No drug interventions	Not Available	Not Available	unknown_status
NCT00027430	Androgen Replacement Therapy in Women With Hypopituitarism	Camphor Menthol Methyl salicylate 2-ethylbutyrate Peppermint oil	treatment	Not Available	completed
NCT00360074	Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatment and Triiodothyronine Supplementation	Liothyronine	treatment	4	completed
NCT05188131	Acute Neuroendocrine Response to Intravenous Infusion of Diclofenac Sodium	Diclofenac	diagnostic	4	completed
NCT05319301	Identification and Clinical Relevance of an Oxytocin Deficient State (Melatonin Study)	No drug interventions	diagnostic	Not Available	completed
NCT03708523	Next Day Growth Hormone Predicting Pituitary Function After Adenomectomy	No drug interventions	Not Available	Not Available	unknown_status