Bone pain (DBCOND0016497)

Identifiers

Synonyms

Pain of the Bone and Bones / Osteodynia / Skeletal pain / Bone pain (finding) / Pain bone / Ostealgia

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Denosumab	A RANK ligand (RANKL) inhibitor used for the management of osteoporosis in patients at high risk for bone fractures.	Tumor necrosis factor ligand superfamily member 11target
Methyl salicylate	A topical counter-irritant used for the symptomatic relief of acute musculoskeletal pain in the muscles, joints, and tendons.	Transient receptor potential cation channel subfamily A member 1target
Samarium (153Sm) lexidronam	A chelated complex of samarium isotope and EDTMP that concentrates in areas with high bone turnover such as sites of metastases to relieve pain associated with osteoblastic metastatic bone lesions.	No drug targets
Strontium chloride	A medication used to treat bone pain in skeletal metastases.	No drug targets
Strontium chloride Sr-89	A radiopharmaceutical agent used for the relief of bone pain in patients with painful skeletal metastases.	Alkaline phosphatase, germ cell typeenzyme Alkaline phosphatase, tissue-nonspecific isozymeenzyme Adenosine triphosphate (ATP)enzyme Sodium/calcium exchanger 1transporter Voltage-dependent T-type calcium channel subunit alpha-1Itransporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03858205	Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma	No drug interventions	treatment	Not Available	recruiting
NCT05841186	Correlation of Timing of Pegfilgrastim Administration and PIBP.	No drug interventions	treatment	Not Available	recruiting
NCT03883386	Loratadine for Improvement of Bone Pain in Patients With Chronic Granulocyte-Colony Stimulating Factor (G-CSF) Use	Loratadine	supportive_care	2	terminated
NCT03529565	Histamine and Bone Pain Association in Participants With Breast Cancer Metastatic in the Bone	No drug interventions	Not Available	Not Available	active_not_recruiting