Identification

Summary

Strontium chloride is a medication used to treat bone pain in skeletal metastases.

Generic Name
Strontium chloride
DrugBank Accession Number
DB13987
Background

Strontium chloride (SrCl2) is a salt of strontium and chloride. SrCl2 is useful in reducing tooth sensitivity by forming a barrier over microscopic tubules in the dentin containing nerve endings that have become exposed by gum recession 1,2. This kind of barrier protection for tooth hypersensitivity has, however, been superseded by other toothpaste formulations and ingredients designed to be nerve calming agents instead 1,2. Such strontium chloride toothpaste formulations may subsequently not be available for sale anymore in certain parts of the world 1,2.

Type
Small Molecule
Groups
Approved
Structure
Weight
Average: 158.52
Monoisotopic: 157.843318
Chemical Formula
Cl2Sr
Synonyms
  • strontium dichloride

Pharmacology

Indication

When employed as an ingredient in toothpaste formulations, strontium chloride is predominantly indicated for treating teeth hypersensitivity 1,2,3,8.

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Associated Conditions
Contraindications & Blackbox Warnings
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Pharmacodynamics

As an active ingredient in a toothpaste formulation, strontium chloride and the rest of the toothpaste product that it is incorporated into is designed to come into contact with and topically coat the teeth 1,2,3 that are being brushed and is not supposed to be swallowed. The regular use of the toothpaste maintains protection that strontium chloride provides against tooth sensitivity despite the normal everyday wear, tear, and cleaning of teeth.

Mechanism of action

For dental hypersensitivity, strontium ions in strontium chloride toothpaste formulations appear to relieve pain and sensitivity by blocking fluid flow in dentinal tubules, which are essentially microscopic canals in the dentin 1,2,3. Regular use of such toothpastes maintains the strontium chloride barricading of the tubules despite normal everyday wear, tear, and washing of teeth.

Absorption

About 30 percent of ingested strontium is absorbed into the blood through the gut 5. The amount of strontium absorbed tends to decrease with age and is higher (about 60 percent) in children in their first year of life 5. Once it is absorbed into the blood, most of it ends up in bone; with the remainder going to soft tissues or being excreted in urine, feces, and sweat 5. About 8 percent of ingested strontium remains in the body after 30 days, and this decreases to about 4 percent after 1 year 5.

Volume of distribution

The distribution of absorbed strontium in the human body is similar to that of calcium, with about 99% of total amount in the body being distributed in the skeleton 8.

Protein binding

A protein binding of 30-40% has been documented for strontium chloride 6.

Metabolism

Strontium can bind to proteins and, based on its similarity to calcium, probably forms complexes with various inorganic anions, such as carbonate and phosphate, and carboxylic acids, such as citrate and lactate 8. Strontium can also interact with ligands that normally bind calcium, like hypoxyapatite, the main component of mineralized bone, and a variety of calcium-binding and calcium transport proteins that are important in the physiological disposition of calcium in cells, including Ca2+ adenosine triphosphatases, Na+Ca+ antiport], and Ca2+ channels 8.

Route of elimination

Once strontium is absorbed into the blood, most of it ends up in bone; with the remainder going to soft tissues or being excreted in urine, feces, and sweat 5.

Half-life

Readily accessible information about the half-life of strontium calcium used in toothpastes is not available.

Clearance

Despite being the major route of excretion of absorbed strontium, urinary excretion of absorbed strontium is observed to be slow 8.

Adverse Effects
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Toxicity

Overdosage with strontium chloride toothpaste formulations has not been reported.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbacavirAbacavir may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
AceclofenacAceclofenac may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
AcemetacinAcemetacin may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
AcetaminophenAcetaminophen may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
AcetazolamideAcetazolamide may increase the excretion rate of Strontium chloride which could result in a lower serum level and potentially a reduction in efficacy.
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
AclidiniumAclidinium may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
AcrivastineAcrivastine may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
AcyclovirAcyclovir may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Adefovir dipivoxilAdefovir dipivoxil may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
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Food Interactions
No interactions found.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Strontium chloride hexahydrateO09USB7Z4410025-70-4AMGRXJSJSONEEG-UHFFFAOYSA-L
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Lorvic DesensitizerStrontium chloride (3.96 %) + Sodium fluoride (0.42 %)GelDentalLorvic Corp1969-12-312001-08-06Canada flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as alkaline earth metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a lanthanide.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkaline earth metal salts
Sub Class
Alkaline earth metal chlorides
Direct Parent
Alkaline earth metal chlorides
Alternative Parents
Inorganic chloride salts
Substituents
Alkaline earth metal chloride / Inorganic chloride salt / Inorganic salt
Molecular Framework
Not Available
External Descriptors
inorganic chloride, strontium salt (CHEBI:36383)
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
EKE8PS9J6Z
CAS number
10476-85-4
InChI Key
AHBGXTDRMVNFER-UHFFFAOYSA-L
InChI
InChI=1S/2ClH.Sr/h2*1H;/q;;+2/p-2
IUPAC Name
strontium(2+) dichloride
SMILES
[Cl-].[Cl-].[Sr++]

References

General References
  1. Karim BF, Gillam DG: The efficacy of strontium and potassium toothpastes in treating dentine hypersensitivity: a systematic review. Int J Dent. 2013;2013:573258. doi: 10.1155/2013/573258. Epub 2013 Apr 8. [Article]
  2. Bartold PM: Dentinal hypersensitivity: a review. Aust Dent J. 2006 Sep;51(3):212-8; quiz 276. [Article]
  3. Natural Medicines Comprehensive Database: Strontium Monograph [Link]
  4. Colgate: How Long Should You Brush Your Teeth For? [Link]
  5. Pennsylvania Department of Health: Strontium [Link]
  6. PubChem: Strontium Chloride [Link]
  7. INVIMA: Acta 13 (28 April 1999) [Link]
  8. INCHEM Strontium and strontium compounds Profile [File]
ChemSpider
55440
RxNav
37175
ChEMBL
CHEMBL2219640
Wikipedia
Strontium_chloride
MSDS
Download (42.6 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3Unknown StatusTreatmentOsteoarthritis (OA) / Pain1
2CompletedTreatmentAmputation Stumps / Pain1
2, 3CompletedTreatmentDentin Sensitivity1
Not AvailableCompletedBasic ScienceOocyte Fertilization1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
GelDental
Injection, powder, for solutionIntravenous37 MBq
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility51.8 mg/mLALOGPS
logP0.84ALOGPS
logP-0.3Chemaxon
logS-0.49ALOGPS
pKa (Strongest Acidic)3.09Chemaxon
Physiological Charge2Chemaxon
Hydrogen Acceptor Count0Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area0 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity0 m3·mol-1Chemaxon
Polarizability1.78 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at February 10, 2018 22:01 / Updated at December 03, 2022 09:38