On and off phenomenon

DBCOND0017875Mental DisordersNervous System Diseases

On and off phenomenon is the indication for 2 drugs in DrugBank. It is covered by 2 curated, structured indications.

Also known as
Parkinson's Disease With End of Dose "Wearing Off" · Parkinson's Disease With Wearing-off Motor Fluctuations · Parkinson's Disease With End of Dose Wearing Off · Off Episodes of Parkinson Disease · Parkinson's Disease With Motor Fluctuations
Classified under
Indicated drugs

Resolves to

Vocabularies
MedDRA10030312

What you can answer from here — as of October 22, 2026

2Indicated drugsWith each drug's targets and mechanism
Listed above
2Structured indicationsPopulation, line of therapy, route and combination as fields, not prose
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8Clinical trialsPhase, status and sponsor resolved per trial
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3Drugs reporting it as an adverse effectWith incidence where the label states it
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Which approved drugs for On and off phenomenon share a target, and which companies have late-stage candidates against it?

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