Macrocytic anemia (DBCOND0020592)

Identifiers

Synonyms

Anemia Macrocytic / Anemia, Macrocytic / Anaemia macrocytic / Macrocytic anaemia / Macrocytic anemia (disorder) / Macrocytic anaemia NOS

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Folic acid	A nutrient used to treat megaloblastic anemia and is found in many supplements.	Folate receptor gammatarget Folate receptor betatarget Methylenetetrahydrofolate reductase (NADPH)enzyme ATP-binding cassette sub-family C member 4transporter Solute carrier family 22 member 6transporter ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Proton-coupled folate transportertransporter Solute carrier family 25 member 32transporter Gamma-glutamyl hydrolaseenzyme Folate receptor alphatarget Dihydrofolate reductaseenzyme Proton-coupled folate transportertarget Reduced folate transportertarget
Leucovorin	A folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer.	Organic anion transporter 3transporter Proton-coupled folate transportertarget Dihydrofolate reductasetarget
NADH	A nutrient used in some supplement products.	UDP-glucose 6-dehydrogenasetarget Alcohol dehydrogenase 1Atarget Sorbitol dehydrogenasetarget All-trans-retinol dehydrogenase [NAD(+)] ADH4target Alcohol dehydrogenase 1Ctarget All-trans-retinol dehydrogenase [NAD(+)] ADH1Btarget All-trans-retinol dehydrogenase [NAD(+)] ADH7target Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmictarget L-lactate dehydrogenase A-like 6Atarget Alcohol dehydrogenase class-3target Aldo-keto reductase family 1 member B1target 3-hydroxyacyl-CoA dehydrogenase type-2target Malate dehydrogenase, mitochondrialtarget L-lactate dehydrogenase A chaintarget NAD-dependent malic enzyme, mitochondrialtarget Peroxisomal multifunctional enzyme type 2target L-lactate dehydrogenase A-like 6Btarget L-lactate dehydrogenase C chaintarget L-lactate dehydrogenase B chaintarget Peroxisomal bifunctional enzymetarget Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialtarget NADP-dependent malic enzyme, mitochondrialtarget D-beta-hydroxybutyrate dehydrogenase, mitochondrialtarget Malate dehydrogenase, cytoplasmictarget 3-hydroxyisobutyrate dehydrogenase, mitochondrialtarget 17-beta-hydroxysteroid dehydrogenase type 3target 3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget NADP-dependent malic enzymetarget D-3-phosphoglycerate dehydrogenasetarget 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7target Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialtarget Isocitrate dehydrogenase [NAD] subunit beta, mitochondrialtarget Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialtarget 17-beta-hydroxysteroid dehydrogenase type 1target 17-beta-hydroxysteroid dehydrogenase type 2target Retinol dehydrogenase 5target GDH/6PGL endoplasmic bifunctional proteintarget (3R)-3-hydroxyacyl-CoA dehydrogenasetarget Aldo-keto reductase family 1 member C4target Inosine-5'-monophosphate dehydrogenase 2target Aldo-keto reductase family 1 member C3target 15-hydroxyprostaglandin dehydrogenase [NAD(+)]target GDP-L-fucose synthasetarget Aldo-keto reductase family 1 member C1target 11-beta-hydroxysteroid dehydrogenase 1target 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2target 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target Inosine-5'-monophosphate dehydrogenase 1target Trifunctional enzyme subunit alpha, mitochondrialtarget Aldehyde dehydrogenase, mitochondrialtarget 11-beta-hydroxysteroid dehydrogenase type 2target Aldo-keto reductase family 1 member C2target Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylatingtarget Aldehyde dehydrogenase family 3 member B2target Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrialtarget Aldehyde dehydrogenase, dimeric NADP-preferringtarget Aldehyde dehydrogenase 1A1target Glyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget 4-trimethylaminobutyraldehyde dehydrogenasetarget Retinaldehyde dehydrogenase 3target Aldehyde dehydrogenase X, mitochondrialtarget Aldehyde dehydrogenase family 3 member B1target Glyceraldehyde-3-phosphate dehydrogenasetarget Retinal dehydrogenase 2target Aldehyde dehydrogenase family 3 member A2target Succinate-semialdehyde dehydrogenase, mitochondrialtarget Alpha-aminoadipic semialdehyde dehydrogenasetarget Flavin reductase (NADPH)target Pyrroline-5-carboxylate reductase 2target Pyrroline-5-carboxylate reductase 1, mitochondrialtarget Glutamate dehydrogenase 1, mitochondrialtarget Pyruvate dehydrogenase E1 component subunit beta, mitochondrialtarget Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrialtarget Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrialtarget Biliverdin reductase Atarget Short-chain specific acyl-CoA dehydrogenase, mitochondrialtarget Dihydrofolate reductasetarget 2-oxoglutarate dehydrogenase complex component E1target Glutamate dehydrogenase 2, mitochondrialtarget 7-dehydrocholesterol reductasetarget Ribosyldihydronicotinamide dehydrogenase [quinone]target NADH-ubiquinone oxidoreductase chain 2target Alpha-aminoadipic semialdehyde synthase, mitochondrialtarget NADH-ubiquinone oxidoreductase chain 3target NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialtarget C-1-tetrahydrofolate synthase, cytoplasmictarget Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialtarget Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrialtarget NADH-cytochrome b5 reductase 3target NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11target NADH-ubiquinone oxidoreductase chain 4target Dihydropteridine reductasetarget NADH-ubiquinone oxidoreductase chain 1target NAD(P) transhydrogenase, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5target NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialtarget NADH-ubiquinone oxidoreductase chain 4Ltarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7target NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1target NADH-ubiquinone oxidoreductase chain 6target NADH-ubiquinone oxidoreductase chain 5target Cytochrome c oxidase subunit NDUFA4target NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6target Acyl carrier protein, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2target NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8target NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3target NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 subunit C2target NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1target NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10target NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4target NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3target NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7target NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9target NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6target NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialtarget Dihydrolipoyl dehydrogenase, mitochondrialtarget NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialtarget Glutathione reductase, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12target NADH dehydrogenase [ubiquinone] iron-sulfur protein 5target NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialtarget NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialtarget NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13target Cysteine dioxygenase type 1target NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2target NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialtarget Cytochrome P450 4A11target Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialtarget Aminomethyltransferase, mitochondrialtarget Methylsterol monooxygenase 1target Heme oxygenase 1target Heme oxygenase 2target Steroid 17-alpha-hydroxylase/17,20 lyasetarget Tyrosinasetarget Xanthine dehydrogenase/oxidaseenzyme Aldehyde oxidaseenzyme Alcohol dehydrogenase 6enzyme Aldo-keto reductase family 1 member A1enzyme Alcohol dehydrogenase 1Aenzyme All-trans-retinol dehydrogenase [NAD(+)] ADH1Benzyme All-trans-retinol dehydrogenase [NAD(+)] ADH4enzyme Alcohol dehydrogenase class-3enzyme All-trans-retinol dehydrogenase [NAD(+)] ADH7enzyme
Nicotinamide	An ingredient found in a variety of cosmetic products.	NAD-dependent protein deacylase sirtuin-5, mitochondrialtarget ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2target Exotoxin Atarget L-lactate dehydrogenase A chaintarget Poly [ADP-ribose] polymerase 1target Cytochrome P450 2D6enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme
Pyridoxine	A vitamin used to correct vitamin B6 deficiency and to treat nausea during pregnancy.	Pyridoxal kinasetarget Cytochrome P450 1A1enzyme Albumincarrier Pyridoxal kinaseenzyme Chronophinenzyme Alkaline phosphatase, tissue-nonspecific isozymetransporter Alkaline phosphatase, tissue-nonspecific isozymeenzyme Aromatic-L-amino-acid decarboxylasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06223854	Acceptability and Nutritional Impact of Double-fortified Salt Containing Iodine and Folic Acid	No drug interventions	prevention	Not Available	active_not_recruiting
NCT05792241	Acceptability and Nutritional Impact of Double-fortified Salt Containing Iodine and Folic Acid - Phase 1	No drug interventions	Not Available	Not Available	completed