Septicemia (DBCOND0020974)

Identifiers

Synonyms

Septicaemia / Sepsis, unspecified organism / Unspecified septicaemia / Unspecified septicemia / Septicaemia NOS / Bloodstream infection / Infection systemic / Systemic infection / Sepsis / Systemic infection (disorder) / Sepsis NOS

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Ampicillin	A penicillin derivative used for the treatment of a variety of infections caused by gram-positive and gram-negative bacteria as well as some anaerobes.	Albumincarrier Organic cation/carnitine transporter 2transporter Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Penicillin-binding protein 2atarget Penicillin-binding protein 1btarget Penicillin-binding protein 3target Penicillin-binding protein 1Atarget Penicillin-binding protein 2Btarget Monocarboxylate transporter 1transporter Solute carrier family 15 member 1target Solute carrier family 15 member 2target Angiopoietin-1 receptortarget
Aztreonam	A beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria.	Penicillin-binding protein 3target Beta-lactamasetarget Beta-lactamase Toho-1target Peptidoglycan synthase FtsItarget
Cefoxitin	A semi-synthetic, broad-spectrum antibiotic for parenteral administration used for the treatment of serious bacterial infections, such as urinary tract infection, blood infection, bone and joint infection, and lower respiratory tract infection.	Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Peptidoglycan synthase FtsItarget D-alanyl-D-alanine carboxypeptidase DacAtarget D-alanyl-D-alanine carboxypeptidase DacBtarget D-alanyl-D-alanine carboxypeptidase DacCtarget D-alanyl-D-alanine endopeptidasetarget Beta-lactamaseenzyme Penicillin-binding protein 3target Penicillin-binding protein 1btarget Penicillin-binding protein 2atarget Penicillin-binding protein 1Atarget Penicillin-binding protein 2Btarget
Cefuroxime	A cephalosporin indicated for the treatment of a variety of infections including acute bacterial otitis media, several upper respiratory tract infections, skin infections, urinary tract infections, gonorrhea, early Lyme disease, and impetigo.	Penicillin-binding protein 1Atarget Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter
Clavulanic acid	A beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics.	Bacterial beta-lactamase enzymestarget Sodium/glucose cotransporter 1transporter Beta-lactamasetarget
Flucytosine	An antifungal indicated only to treat severe infections throughout the body caused by susceptible strains of Candida or Cryptococcus.	Thymidylate synthasetarget DNA (cytosine-5)-methyltransferase 1target DNAtarget
Piperacillin	A penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam­ susceptible, β-lactamase generating strains of several bacteria.	Solute carrier family 22 member 6transporter Penicillin-binding protein 3target Penicillin-binding protein 2Btarget Penicillin-binding protein 2atarget Penicillin-binding protein 1btarget Organic anion transporter 3transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03929159	Correlating MicroRNA Changes with Sepsis Outcomes	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT05040503	Monitoring Mitophagy In Myeloid Cells Upon Intensive Care	No drug interventions	other	Not Available	recruiting
NCT04636554	Personalized Phage Treatment in Covid-19 Patients With Bacterial Co-Infections Microbials for Pneumonia or Bacteremia/Septicemia	No drug interventions	Not Available	Not Available	no_longer_available
NCT01520597	National Study on Listeriosis and Listeria	No drug interventions	Not Available	Not Available	completed
NCT02069028	Effectiveness of Different Interventions for Implementing Surviving Sepsis Campaign (SSC) Guidelines on Compliance and Mortality: Systematic Review and Meta-analysis	No drug interventions	Not Available	Not Available	unknown_status
NCT03943719	Clinical Impact of the FilmArray Blood Culture Identification Panel Performed on Positive Blood Cultures From Intensive Care Patients With Septicemia	No drug interventions	Not Available	Not Available	completed
NCT04764058	Efficacy and Safety of Colistin Based Antibiotic Therapy	Meropenem	other	1 / 2	unknown_status
NCT05045963	Impact of Aminoglycosides in Hypotensive Septic Oncology Patients	No drug interventions	Not Available	Not Available	recruiting
NCT05893420	A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning	No drug interventions	prevention	Not Available	recruiting
NCT02093494	Study to Evaluate the Effectiveness of the Initial Specimen Diversion Device When Collected Through Peripheral Intravenous Catheters	No drug interventions	diagnostic	Not Available	terminated
NCT00046072	A Safety and Efficacy Study of Intravenous E5564 in Patients With Severe Sepsis	Eritoran	treatment	2	completed
NCT00258869	Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests	No drug interventions	Not Available	Not Available	unknown_status
NCT05358912	Efficacy of Targeted Abdominal Perfusion Pressure in Septic Shock	No drug interventions	prevention	4	completed
NCT02102087	Study to Evaluate the Effectiveness of the Initial Specimen Diversion Device	No drug interventions	diagnostic	Not Available	completed
NCT00146432	Immunoadsorption of LPS, C5a and IL-6 in Severe Sepsis and Septic Shock (ISASS-1)	No drug interventions	treatment	2 / 3	completed
NCT03088865	Evaluation of an Internal Hospital Practice: The Effect of Altered Test Tubes Sampling Order on Blood Culture Contamination Rates	No drug interventions	diagnostic	Not Available	completed
NCT03583762	Time to Appropriate Antibiotic Between Using Microarray Assay and Mass Spectrometry Technique	No drug interventions	treatment	Not Available	unknown_status
NCT00901940	Understanding the Immune Response to Meningitis Vaccines	Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine Meningococcal polysaccharide vaccine group A Meningococcal polysaccharide vaccine group C Meningococcal polysaccharide vaccine group W-135 Meningococcal polysaccharide vaccine group Y	prevention	3	completed
NCT02988414	Diagnosis of Bacteremia/Septicemia and Culture Negative Endocarditis by the Karius Sequencing-Based Infectious Disease Diagnostic Assay	No drug interventions	Not Available	Not Available	completed
NCT01996007	Understanding Pneumococcal Carriage and Disease	No drug interventions	Not Available	Not Available	completed
NCT02208817	The Paediatric Refill Study (PRefill)	No drug interventions	Not Available	Not Available	completed
NCT04439617	Monitoring of the Mitochondrial Function of Circulating Myeloid Cells in Patients Hospitalized in the Intensive Care Unit of Dijon University Hospital	No drug interventions	Not Available	Not Available	completed
NCT02606526	Early Versus Late BCG Vaccination in HIV-1 Exposed Infants in Uganda in Uganda	BCG vaccine	prevention	3	active_not_recruiting
NCT02606565	Efficacy of Umbilical Cord Cleansing With a Single Application of 4% Chlorhexidine for the Prevention of Newborn Infections in Uganda: a Randomized Controlled Trial	Chlorhexidine	prevention	4	unknown_status
NCT01593514	Understanding the Immune Response to Two Different Meningitis Vaccines	Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine Meningococcal polysaccharide vaccine group A Meningococcal polysaccharide vaccine group C Meningococcal polysaccharide vaccine group W-135 Meningococcal polysaccharide vaccine group Y	basic_science	4	completed