Cefoxitin

DB01331ApprovedInvestigationalSmall moleculeCephalosporins

Cefoxitin is a semi-synthetic, broad-spectrum antibiotic for parenteral administration used for the treatment of serious bacterial infections, such as urinary tract infection, blood infection, bone and joint infection, and lower respiratory tract infection. It is derived from cephamycin C, which is produced by Streptomyces lactamdurans.

Mechanism: The bactericidal action of cefoxitin results from inhibition of cell wall synthesis.
Curator reviewed
Primary indication: For the treatment of serious infections caused by susceptible strains microorganisms.Curator reviewed · 18 structured indications
Formula / weight: C₁₆H₁₇N₃O₇S₂ · 427.452 g/mol (avg)
First approval: Canada, 2013 · United States, 1978
Also known as: Ceftoxitin · Cephoxitin · Rephoxitin
Code names: J01DC01

Resolves to

Compound

UNII6OEV9DX57YCAS35607-66-0ChEMBLCHEMBL996ChEBI209807PubChem441199KEGGD02345

Clinical / RWD

RxNorm2189ATCJ01DC01PharmGKBPA448856

Structure

InChIKeyWZOZEZRFJCJXNZ-ZBFHGGJFSA-NSMILES[H][C@]12SCC(COC(N)=O)=C(N1C(=O)[C@]2(NC(=O)CC1=CC=CS1)OC)C(O)=O

Targets

P08506dacCP0AEB2dacAP0AFI5pbpGP24228dacBP02918mrcAP02919mrcBP0AD68ftsIQ75Y35pbp3+4 more

What you can answer from here — as of September 23, 2026

13Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

804Drug interactionsStructured to mechanism, not free text

15Clinical trialsPhase, status and sponsor resolved per trial

18Structured indicationsCondition, population, route and combination as fields, not prose

57Marketed productsAcross 4 countries and 17 labellers

1ATC codeIncluding every combination product, plus 15 drug categories

18+ReferencesStructured and connected to the statements they support

Which drugs share a target with Cefoxitin, and which of those have an active Phase 3 trial?

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