Severe Acute Pain (DBCOND0021329)

Identifiers

Synonyms

Severe Pain, Acute / Acute Severe Pain / Severe Acute pain / Acute, severe Pain

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Celecoxib	An NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis.	Prostaglandin G/H synthase 2target 3-phosphoinositide-dependent protein kinase 1target Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme ATP-binding cassette sub-family C member 4transporter Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme Carbonic anhydrase 2target Carbonic anhydrase 3target Bile salt export pumptransporter Cadherin-11target ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Prostaglandin G/H synthase 2enzyme Sialidase-1target Signal transducer and activator of transcription 3target
Ketorolac	An NSAID used to treat moderate to severe pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders, and headaches.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target UDP-glucuronosyltransferase 2B7enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme
Oliceridine	A biased opioid agonist indicated for the management of severe acute pain in adult patients. Through preferential activation of G-protein-coupled signalling pathways, oliceridine provides analgesic effect with a comparable or improved safety profile over conventional opioid agonists.	Mu-type opioid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme
Oxycodone	An opioid used in the management of moderate to severe pain.	Mu-type opioid receptortarget Kappa-type opioid receptortarget Delta-type opioid receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Albumincarrier alpha1-acid glycoproteincarrier
Sufentanil	An opioid used to induce and maintain anesthesia, to act as an analgesic in labor and delivery, and to treat severe, acute pain.	Mu-type opioid receptortarget Delta-type opioid receptortarget Kappa-type opioid receptortarget Cytochrome P450 3A4enzyme
Tapentadol	An opioid used to manage severe pain that has not responded to non-opioid medications, and for which opioid analgesic therapy is appropriate.	Mu-type opioid receptortarget Kappa-type opioid receptortarget Delta-type opioid receptortarget Sodium-dependent noradrenaline transportertarget UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B7enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Sodium-dependent serotonin transportertarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01892709	Titration of Intravenous Hydromorphone	Hydromorphone	treatment	4	completed