methotrexate toxicity (DBCOND0022071)

Identifiers

Synonyms

Not Available

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Folic acid	A nutrient used to treat megaloblastic anemia and is found in many supplements.	Folate receptor gammatarget Folate receptor betatarget Methylenetetrahydrofolate reductase (NADPH)enzyme ATP-binding cassette sub-family C member 4transporter Solute carrier family 22 member 6transporter ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Proton-coupled folate transportertransporter Solute carrier family 25 member 32transporter Gamma-glutamyl hydrolaseenzyme Folate receptor alphatarget Dihydrofolate reductaseenzyme Proton-coupled folate transportertarget Reduced folate transportertarget
Glucarpidase	A carboxypeptidase enzyme used to reduce plasma concentrations of methotrexate in patients with impaired renal function.	No drug targets
Leucovorin	A folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer.	Organic anion transporter 3transporter Proton-coupled folate transportertarget Dihydrofolate reductasetarget
Turmeric	Turmeric is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06123403	Evaluation of High Dose Methotrexate Toxicity	No drug interventions	Not Available	Not Available	not_yet_recruiting