Fredrickson classification type IV Hyperlipidemia (DBCOND0023044)

Identifiers

Synonyms

Fredrickson Type IV lipidaemia / Fredrickson Type IV lipidemia / Frederickson Type IV Hypertriglyceridemia / Pure hyperglyceridemia / Type IV lipidemia / Type IV lipidaemia / Endogenous hyperlipidemia (disorder) / Fredrickson type IV hyperlipoproteinemia (disorder) / Familial hypertriglyceridaemia / Familial hypertriglyceridemia / Familial hypertriglyceridemia (disorder) / Pure hyperglyceridemia (disorder) / Type IV hyperlipidaemia / Type IV hyperlipidemia / Pure hyperglyceridaemia / Type IV hyperlipoproteinaemia / Hyperlipoproteinemia Type IV / Type IV hyperlipoproteinemia

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acipimox	A niacin derivative used in Fredrickson type IIb and type IV hyperlipoproteinemia.	No drug targets
Atorvastatin	An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.	3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget Cytochrome P450 3A4enzyme Dipeptidyl peptidase 4target Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Solute carrier organic anion transporter family member 1B1transporter ATP-binding cassette sub-family C member 4transporter ATP-binding cassette sub-family C member 5transporter Multidrug resistance-associated protein 1transporter Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Aryl hydrocarbon receptortarget Solute carrier organic anion transporter family member 2B1transporter Solute carrier organic anion transporter family member 1B3transporter UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A3enzyme ATP-binding cassette sub-family C member 2transporter Bile salt export pumptransporter Albumincarrier Histone deacetylase 2target Nuclear receptor subfamily 1 group I member 3target
Bezafibrate	A lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder.	Peroxisome proliferator-activated receptor alphatarget Solute carrier organic anion transporter family member 1B1transporter Peroxisome proliferator-activated receptor deltatarget Peroxisome proliferator-activated receptor gammatarget Cytochrome P450 1A1enzyme Cytochrome P450 2C8enzyme Cytochrome P450 3A4enzyme Nuclear receptor subfamily 1 group I member 2target Retinoic acid receptor RXR-alphatarget Retinoic acid receptor RXR-betatarget Retinoic acid receptor RXR-gammatarget
Doconexent	An omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health.	Cytochrome P450 2C9enzyme Peroxisome proliferator-activated receptor alphatarget Peroxisome proliferator-activated receptor gammatarget Sterol regulatory element-binding protein 1target Retinoic acid receptor RXR-alphatarget Retinoic acid receptor RXR-betatarget Retinoic acid receptor RXR-gammatarget Myc proto-oncogene proteintarget Prostaglandin G/H synthase 2target Prostaglandin G/H synthase 1target
Gemfibrozil	A lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia.	Peroxisome proliferator-activated receptor alphatarget Cytochrome P450 2C9enzyme Cytochrome P450 2C8enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C19enzyme UDP-glucuronosyltransferase 1A1enzyme Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 1A3enzyme Solute carrier organic anion transporter family member 1B1target UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B4enzyme UDP-glucuronosyltransferase 2B17enzyme Albumincarrier Organic anion transporter 3target Solute carrier organic anion transporter family member 2B1target Solute carrier organic anion transporter family member 1B3target Lipoprotein lipasetarget

Clinical Trials

Not Available