advanced Thyroid cancer (DBCOND0023292)

Identifiers

Synonyms

Advanced Thyroid Cancer

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Axitinib	An oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy.	Vascular endothelial growth factor receptor 1target Vascular endothelial growth factor receptor 2target Vascular endothelial growth factor receptor 3target Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C19enzyme UDP-glucuronosyltransferase 1A1enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1B1transporter Tyrosine-protein kinase ABL1target
Pazopanib	An antineoplastic agent used in the treatment of advanced renal cell cancer and advanced soft tissue sarcoma in patients with prior chemotherapy.	Vascular endothelial growth factor receptor 1target Vascular endothelial growth factor receptor 2target Vascular endothelial growth factor receptor 3target Platelet-derived growth factor receptor alphatarget Platelet-derived growth factor receptor betatarget Mast/stem cell growth factor receptor Kittarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 1A2enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter UDP-glucuronosyltransferase 1A1transporter Fibroblast growth factor receptor 3target Tyrosine-protein kinase ITK/TSKtarget Fibroblast growth factor 1target SH2B adapter protein 3target

Clinical Trials

Not Available