Folic acid antagonist overdose (DBCOND0024088)

Identifiers

Synonyms

Folic Acid Deficiency / Deficiency of other specified B group vitamins / Folate deficiency / Folic acid deficiency (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Cyanocobalamin	A vitamin available in many formulations to correct vitamin B12 deficiency.	Methionine synthase reductasetarget Methylmalonic aciduria type A protein, mitochondrialtarget Methylmalonyl-CoA mutase, mitochondrialtarget Cyanocobalamin reductase / alkylcobalamin dealkylasetarget Methionine synthasetarget Methylenetetrahydrofolate reductase (NADPH)target Protein amnionlesstransporter Transcobalamin-1transporter Transcobalamin-2transporter Corrinoid adenosyltransferase MMABenzyme Cobalamin binding intrinsic factortransporter Cubilintransporter Bifunctional adenosylcobalamin biosynthesis protein CobUenzyme Low-density lipoprotein receptor-related protein 2transporter Multidrug resistance-associated protein 1transporter Pancreatic proteasesenzyme
Ferrous fumarate	A medication used to treat iron-deficiency anemia.	Transferrin receptor protein 1target Egl nine homolog 1target Histone deacetylase 8target Alpha-hemoglobin-stabilizing proteintarget Hemoglobin subunit alphatarget Frataxin, mitochondrialtarget Ferritin heavy chaintarget Flap endonuclease 1target Endonuclease 8-like 1target Endonuclease 8-like 2target DNA polymerase betatarget Ceruloplasmintarget Serotransferrintarget
Folic acid	A nutrient used to treat megaloblastic anemia and is found in many supplements.	Folate receptor gammatarget Folate receptor betatarget Methylenetetrahydrofolate reductase (NADPH)enzyme ATP-binding cassette sub-family C member 4transporter Solute carrier family 22 member 6transporter ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Proton-coupled folate transportertransporter Solute carrier family 25 member 32transporter Gamma-glutamyl hydrolaseenzyme Folate receptor alphatarget Dihydrofolate reductaseenzyme Proton-coupled folate transportertarget Reduced folate transportertarget
Leucovorin	A folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer.	Organic anion transporter 3transporter Proton-coupled folate transportertarget Dihydrofolate reductasetarget
Levoleucovorin	A folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer.	Serine hydroxymethyltransferasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00789490	Relative Bioavailability of Iron and Folic Acid in New Test Supplement	No drug interventions	Not Available	1	completed
NCT04096521	Serum Folic Acid Status, Genotyping MTHFR 677C-->T, Plasma Homocysteine, DNA Methylation of IGF2 Gene and Microbiota of the Children: Mother-Children Cohort Study	No drug interventions	Not Available	Not Available	completed
NCT02373033	Folate-Rich Foods Improve Folate Status	No drug interventions	basic_science	Not Available	completed
NCT01297361	The Association Between Religious Origin and Age, and Vitamin B12 and Folic Acid Plasma Levels in Non Jewish Population in Western Galilee	No drug interventions	diagnostic	Not Available	completed
NCT02674022	Screening for Metabolic Problems in Mothers of Children With Autism and Typically Developing Children	No drug interventions	prevention	Not Available	completed
NCT05935631	Feasibility, Acceptability and Directional Signal Effect on Blood Folate Levels of Iodized Salt Fortified With Folic Acid: Clinical Study	No drug interventions	prevention	Not Available	completed
NCT03284840	Adults Nutrition as a Protective or Health-risk Factor	No drug interventions	Not Available	Not Available	completed
NCT04024254	A Study of Serum Folate Levels in Patients Treated With Olaparib	Folic acid	treatment	2 / 3	active_not_recruiting
NCT06174883	Salt-FA to Increase Folate Levels	No drug interventions	Not Available	Not Available	completed
NCT00162409	Relationship Between Folic Acid and Warfarin Metabolism and Effect	Folic acid	treatment	Not Available	unknown_status
NCT04180800	Studying the Association Between Folic Acid Deficiency and Social Isolation for Elderly Patients	No drug interventions	Not Available	Not Available	completed
NCT05389618	Dietary Challenges in the Population of Nursing Homes' Residents	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT03978260	Preoperative Anaemia prevaLence In surgiCal patiEnts	No drug interventions	Not Available	Not Available	completed
NCT01412580	In Utero Capacity Formation and Socio-economic Outcomes	No drug interventions	Not Available	Not Available	completed
NCT05453708	Maternal Risk Factors for Autism Spectrum Disorders: A Case-Control Approach	No drug interventions	Not Available	Not Available	completed