Severe Plaque psoriasis (DBCOND0025583)

Identifiers

Synonyms

Severe Plaque Psoriasis

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Bimekizumab	An anti-IL-17A, IL-17F, and IL-17AF monoclonal antibody used in the treatment plaque psoriasis.	Interleukin-17Atarget Interleukin-17Ftarget
Brodalumab	A monoclonal antibody used to treat moderate to severe plaque psoriasis.	No drug targets
Clobetasol propionate	A corticosteroid used to treat corticosteroid-responsive dermatoses and plaque psoriasis.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Annexin A1target Mineralocorticoid receptortarget Corticosteroid-binding globulincarrier Albumincarrier
Deucravacitinib	A TYK2 inhibitor being investigated as a treatment for psoriasis.	Non-receptor tyrosine-protein kinase TYK2target Cytochrome P450 1A2enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2D6enzyme Cocaine esteraseenzyme UDP-glucuronosyltransferase 1A9enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier family 22 member 1transporter Solute carrier organic anion transporter family member 1B3transporter
Etanercept	A protein therapy based on the binding fragment of the tumour necrosis factor alpha receptor used to treat severe rheumatoid arthritis and moderate to severe plaque psoriasis.	Tumor necrosis factortarget Lymphotoxin-alphatarget Low affinity immunoglobulin gamma Fc region receptor III-Btarget Low affinity immunoglobulin gamma Fc region receptor III-Atarget High affinity immunoglobulin gamma Fc receptor Itarget Low affinity immunoglobulin gamma Fc region receptor II-atarget Low affinity immunoglobulin gamma Fc region receptor II-btarget Low affinity immunoglobulin gamma Fc region receptor II-ctarget Complement component 1q (C1q)target
Guselkumab	A monoclonal antibody used to treat moderate to severe plaque psoriasis.	Interleukin-23 subunit alphatarget
Secukinumab	An immunomodulating agent and interleukin antagonist used to manage plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, along with other joint inflammatory disorders.	Interleukin-17Atarget
Ustekinumab	A targeted antibody therapy used to manage inflammatory conditions such as plaque psoriasis, psoriatic arthritis, Crohn's Disease, and ulcerative colitis.	Interleukin-12 subunit betatarget Interleukin-23target

Clinical Trials

Not Available