Clobetasol propionate is a corticosteroid used to treat corticosteroid-responsive dermatoses and plaque psoriasis. Clobetasol propionate is a prednisolone derivative with higher specificity for glucocorticoid receptors than mineralocorticoid receptors.
- Mechanism
- Curator reviewed · 5 references
The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation. Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days.
Glucocorticoids inhibit neutrophil apoptosis and demargination; they inhibit phospholipase A2, which decreases the formation of arachidonic acid derivatives; they inhibit NF-Kappa B and other inflammatory transcription factors; they promote anti-inflammatory genes like interleukin-10.
Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive. High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels.
- Primary indication
- Clobetasol propionate is indicated to treat moderate to severe plaque psoriasis as well as inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.Curator reviewed · 15 structured indications
- Formula / weight
- C25H32ClFO5 · 466.97 g/mol (avg)
- First approval
- Canada, 1996 · United States, 1990
- Also known as
- clobetasol 17-propanoate · clobetasol 17-propionate · Clobetasol propionate E
- Code names
- CCI-4725 · GR-2/925
- Brand names
Resolves to
CBGUOGMQLZIXBE-XGQKBEPLSA-NSMILES[H][C@@]12C[C@H](C)[C@](OC(=O)CC)(C(=O)CCl)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12CWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Clobetasol propionate, and which of those have an active Phase 3 trial?
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