Stage III Melanoma (DBCOND0028661)

Identifiers

Synonyms
Stage 3 Melanoma / Clinical Stage III Cutaneous Melanoma AJCC v8

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Pembrolizumab
A PD-1 blocking antibody used to treat various types of cancer, including metastatic melanoma, non small-cell lung cancer, cervical cancer, head and neck cancer, and Hodgkin's lymphoma.
Trametinib
A kinase inhibitor used alone or in combination with dabrafenib to treat patients with cancers with specific BRAF mutations, such as melanoma and non-small cell lung cancer.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05289193
CD8+ T Cell Imaging During Pre-surgery Immunotherapy in People With Melanomatreatment2recruiting
NCT05655312
MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanomatreatment1 / 2recruiting
NCT05970497
A Study Assessing KB707 for the Treatment of Locally Advanced or Metastatic Solid TumorsNo drug interventionstreatment1recruiting
NCT06284590
Study of the Efficacy of Intratumoral L19IL2 or L19TNF or L19IL2/L19TNF, in Combination With Pembrolizumab, in Unresectable Melanoma Patientstreatment2active_not_recruiting
NCT06551064
Assessment of PK Similarity of FYB206 in Comparison With Keytruda in Resected Stage II or III Melanoma Patientstreatment1recruiting
NCT04013854
Adjuvant Treatment Determined By Pathological Response To Neoadjvuant Nivolumabtreatment2recruiting
NCT03200847
Pembrolizumab and All-Trans Retinoic Acid Combination Treatment of Advanced Melanomatreatment1 / 2active_not_recruiting
NCT00003647
Chemotherapy With or Without Immunotherapy in Treating Patients With Stage III or Stage IV Melanomatreatment3completed
NCT04305145
Infliximab for Treatment of Immune Checkpoint Inhibitor Colitistreatment2recruiting
NCT05732805
A Clinical Study of BCD-217 (Nurulimab + Prolgolimab) Followed by Anti-PD-1 Compared to Anti-PD-1 Monotherapy as First-Line Treatment in Subjects With Unresectable/Metastatic Melanomatreatment3recruiting
NCT05940311
Versatile Ampification Single-Molecule Detection in Liquid BiopsyNo drug interventionsNot AvailableNot Availablerecruiting
NCT06299878
MelPRO-0322 (CRISTINA Trial) [miCrobiome pRedIctS aPD1 effecTivnes In melaNoma pAtietns]No drug interventionsNot AvailableNot Availablerecruiting
NCT04007588
A Phase II Trial of Neoadjuvant Treatment With PD-1 Inhibition (Nivolumab) With or Without IDO Inhibition (BMS-986205) and With or Without CTLA-4 Inhibition (Ipilimumab) in Resectable Stage III or IV Melanomatreatment2withdrawn
NCT05370807
A Clinical Trial of Regorafenib in Patients With Pretreated Advanced Melanomatreatment2recruiting
NCT04598009
Binimetinib and Imatinib for Unresectable Stage III-IV KIT-Mutant Melanomatreatment2recruiting
NCT03161756
Evaluation of Denosumab in Combination With Immune Checkpoint Inhibitors in Patients With Unresectable or Metastatic Melanomatreatment1 / 2unknown_status
NCT00030615
Decitabine in Treating Patients With Advanced Solid Tumorstreatment1completed
NCT06295159
Neoadjuvant and Adjuvant Anti-PD1 or Combinations for Locoregionally Advanced Melanomatreatment0recruiting
NCT05402059
Clinical Outcomes and Biomarkers in Patients With Stage 0-IV Melanoma in Real Clinical PracticeNo drug interventionsNot AvailableNot Availablerecruiting
NCT00217542
Azacitidine and Recombinant Interferon Alfa-2b in Treating Patients With Stage III or Stage IV Melanoma or Stage IV Kidney Cancer That Cannot Be Removed By Surgerytreatment1completed
NCT04526899
Trial With BNT111 and Cemiplimab in Combination or as Single Agents in Patients With Anti-PD-1-refractory/Relapsed, Unresectable Stage III or IV Melanomatreatment2active_not_recruiting
NCT02794636
Interferon Toxicities in Melanoma TreatmentNo drug interventionsNot AvailableNot Availablecompleted
NCT06199713
Correlating Early FDG PET/CT and ctDNA in Immune Checkpoint Inhibitor (ICI)-Treated Melanoma PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT03190824
Evaluate Efficacy, Immunological Response of Intratumoral/Intralesional Oncolytic Virus (OBP-301) in Metastatic Melanomatreatment2unknown_status
NCT04154163
Appropriate Dosing to Optimise Personalised Cancer TreatmentsNo drug interventionsNot AvailableNot Availablecompleted
NCT03385486
Study of TBX-3400 in Patients With Stage III and IV Melanoma Resistant or Refractory to Immune Checkpoint Inhibitorstreatment1recruiting
NCT04207086
A Phase II Study of Neoadjuvant Pembrolizumab & Lenvatinib for Resectable Stage III Melanomatreatment2active_not_recruiting
NCT04079166
SCIB1 and iSCIB1+ in Melanoma Patients Receiving Nivolumab With Ipilimumab or SCIB1 With Pembrolizumab (The SCOPE Study)treatment2recruiting
NCT05171374
pRospective Evaluation of Clinical Outcomes in Patients With metAsTatIс melanOma Treated With dabrafeNib and trAmetinib in reaL practicENot AvailableNot Availablerecruiting
NCT03161431
SX-682 Treatment in Subjects With Metastatic Melanoma Concurrently Treated With Pembrolizumabtreatment1recruiting
NCT00089362
Alvespimycin Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumorstreatment1completed
NCT02676869
Phase 1 Study of IMP321 (Eftilagimod Alpha) Adjuvant to Anti-PD-1 Therapy in Unresectable or Metastatic Melanomatreatment1completed
NCT00003646
Gene Therapy in Treating Patients With Stage III or Stage IV Melanomatreatment2completed
NCT02073123
Study of IDO Inhibitor in Combination With Checkpoint Inhibitors for Adult Patients With Metastatic Melanomatreatment1 / 2completed
NCT04455503
Study of Adjuvant Immunotherapy With EVX-02 and Anti-PD-1treatment1 / 2terminated
NCT00019890
Vaccine Therapy in Treating Patients With High-Risk Stage III or Completely Resected Metastatic Melanomatreatment2completed
NCT05309421
A Single Arm Trial Evaluating the Efficacy and Safety of EVX-01 in Combination With Pembrolizumab in Adults With Unresectable or Metastatic Melanomatreatment2recruiting
NCT04139902
Neoadjuvant PD-1 Inhibitor Dostarlimab (TSR-042) vs. Combination of Tim-3 Inhibitor Cobolimab (TSR-022) and PD-1 Inhibitor Dostarlimab (TSR-042) in Melanomatreatment2recruiting
NCT05767879
(Neo)Adjuvant BRAF/MEK Inhibition in pN1c Melanomatreatment2recruiting
NCT01026051
Safety, Immune and Tumor Response to a Multi-component Immune Based Therapy (MKC1106-MT) for Patients With MelanomaNo drug interventionstreatment2terminated
NCT01875653
Autologous Dendritic Cell-Tumor Cell Immunotherapy for Metastatic Melanomatreatment3terminated
NCT04410445
Study to Compare Adjuvant Immunotherapy of Bempegaldesleukin Combined With Nivolumab Versus Nivolumab After Complete Resection of Melanoma in Patients at High Risk for Recurrencetreatment3terminated
NCT04741997
Adjuvant Therapy Based on Pathologic Response After Neoadjuvant Encorafenib Binimetinib in Melanomatreatment0recruiting
NCT04513028
Beta Glucan's Effect on Pembrolizumab Immunologic Response in Stage III-IV MelanomaNo drug interventionstreatmentNot Availablerecruiting
NCT05751928
A Study of Neoadjuvant Therapy With BCD-217 (Nurulimab + Prolgolimab) in Patients With Resectable Stage III Skin Melanomatreatment3recruiting
NCT03605771
Descriptive Observational Study on the Characteristics of Advanced and Metastatic Melanoma in SpainNo drug interventionsNot AvailableNot Availablerecruiting
NCT03153085
A Study of Combination With TBI-1401(HF10) and Ipilimumab in Japanese Patients With Unresectable or Metastatic Melanomatreatment2completed
NCT05467137
Sentinel Lymph Node Detection in Patients With Stage Ib-III Melanoma Using MSOT and ICGNo drug interventionsdiagnostic4unknown_status
NCT05445752
Conservative Nodal Surgery (Node-picking) of Patients With Stage III Melanoma With Low-burden of Nodal Disease (MELCONSURG MULTICENTRE COHORT)No drug interventionsNot AvailableNot Availablerecruiting
NCT00082875
Cilengitide in Treating Patients With Unresectable or Metastatic Melanomatreatment2terminated
NCT06508775
Long-Term Follow-up of Patients Treated With Miltenyi Cell and Gene TherapiesotherNot Availablerecruiting
NCT05827770
The Efficacy and Safety of Neoadjuvant Toripalimab Combined With Temozolomide in Resectable Stage III Melanomatreatment2not_yet_recruiting
NCT00349206
Sorafenib and Temsirolimus in Treating Patients With Metastatic, Recurrent, or Unresectable Melanomatreatment1completed
NCT00119249
Sorafenib in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed By Surgerytreatment2completed
NCT05079113
Leveraging ctDNA Analysis to Improve Early Detection of Cancer Recurrence in the High-Risk Melanoma SettingNo drug interventionsNot AvailableNot Availablecompleted
NCT01376713
Anti-CD20 (Cluster of Differentiation Antigen 20) Therapy to Treat Metastatic Melanomatreatment2completed
NCT03620019
Denosumab + PD-1 in Subjects With Stage III/ IV Melanomatreatment2completed
NCT04059224
TraMel-WT: A Trial of Trametinib in Patients With Advanced Pretreated BRAFV600 Wild-type Melanomatreatment2completed
NCT00087386
Tanespimycin in Treating Patients With Stage III-IV Melanomatreatment2terminated
NCT04330430
Neo-adjuvant T-VEC + Nivolumab Combination Therapy for Resectable Early Metastatic (Stage IIIB/C/D-IV M1a) Melanoma With Injectable Diseasetreatment2active_not_recruiting
NCT04703426
Sargramostim (GM-CSF) + PD-1treatment2withdrawn
NCT01107665
Pazopanib and Paclitaxel as First-Line Treatment for Subjects With Unresectable Stage III and Stage IV Melanomatreatment2completed
NCT03719131
Rituximab and Hyaluronidase Human in Patients With Advanced Melanoma Undergoing Nivolumab and Ipilimumab Therapytreatment2active_not_recruiting
NCT05652673
Safe Stop Ipilimumab-nivolumab (IPI-NIVO) TrialtreatmentNot Availablerecruiting
NCT04045691
Binimetinib Plus Encorafenib Real Life Investigation of Next Generation Melanoma TreatmentNot AvailableNot Availablerecruiting
NCT06204991
To Evaluate the Safety and Efficacy of ADP-TILIL7 in Patients With Locally Advanced or Metastatic Melanomatreatment1not_yet_recruiting
NCT04562129
IL2 With Ipilimumab Followed by Nivolumab in Stage 3 or 4 Melanoma Patientstreatment2recruiting
NCT05251389
FMT to Convert Response to ImmunotherapyNo drug interventionstreatment1 / 2recruiting
NCT00003789
Melphalan With or Without Tumor Necrosis Factor in Treating Patients With Locally Advanced Melanoma of the Arm or Legtreatment3completed
NCT00945269
Therapeutic Autologous Lymphocytes, Aldesleukin, and Denileukin Diftitox in Treating Patients With Stage III-IV Melanomatreatment1 / 2terminated
NCT04675346
Exploring Unmet Needs and Attitudes to Skin Self-examination in Melanoma SurvivorsNo drug interventionsNot AvailableNot Availablecompleted
NCT00450255
VEGF Trap in Treating Patients With Recurrent Stage III or Stage IV Melanoma That Cannot Be Removed by Surgerytreatment2completed
NCT02306850
Neoadjuvant Pembrolizumab for Unresectable Stage III and Unresectable Stage IV Melanomatreatment2completed
NCT01168050
Efficacy of Nilotinib in First or Second Line Treatment of Primary Melanomas Stage III Unresectable Melanomas.treatment2unknown_status
NCT00074308
Imatinib Mesylate and Bevacizumab in Treating Patients With Advanced Melanoma or Other Advanced Cancerstreatment1 / 2completed
NCT01851408
Sorafenib and Temsirolimus in Treating Patients With Metastatic, Recurrent, or Unresectable Melanomatreatment2withdrawn
NCT01726738
LCCC 1128: Open Label Phase II Trial of the BRAF Inhibitor (Dabrafenib) and the MEK Inhibitor (Trametinib) in Unresectable Stage III and Stage IV BRAF Mutant Melanoma; Correlation of Resistance With the Kinome and Functional Mutationstreatment2completed