Stage IV Gastric Cancer (DBCOND0028764)

Identifiers

Synonyms
Advanced Gastric Cancer / Gastric cancer stage IV / Metastatic gastric cancer / Gastric cancer stage IV NOS / Malignant neoplasm of stomach stage IV NOS / Gastric malignancy stage IV NOS / Stomach cancer stage IV NOS

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Gimeracil
A DPD inhibitor used as an adjunct to antineoplastic therapy to increase the systemic concentrations and therapeutic effectiveness of other antineoplastic agents.
Leucovorin
A folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer.
Oteracil
A chemotherapy agent used in combination with tegafur, cisplatin and gimeracil to treat advanced gastric cancer.
No drug targets
Tegafur
An antineoplastic agent used in combination with other anticancer medications to treat advanced gastric and colorectal cancers.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT01249443
Paclitaxel and Carboplatin in Treating Patients With Metastatic or Recurrent Solid Tumors and HIV Infectiontreatment1terminated
NCT06034964
Tislelizumab Combined With Chemotherapy in First-line Treatment of AGCNot AvailableNot Availableactive_not_recruiting
NCT02511821
Electronic Monitoring Device of Patient-Reported Outcomes and Function in Improving Patient-Centered Care in Patients With Gastrointestinal Cancer Undergoing SurgeryNo drug interventionsdevice_feasibilityNot Availablecompleted
NCT04670445
Improving Patient and Caregiver Understanding of Risks and Benefits of Immunotherapy for Advanced CancerNo drug interventionshealth_services_researchNot Availableactive_not_recruiting
NCT01233505
Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumorstreatment1terminated
NCT04221893
Radiation Therapy for the Treatment of Metastatic Gastrointestinal CancersNo drug interventionstreatmentNot Availablerecruiting
NCT00061932
Bortezomib With or Without Irinotecan in Treating Patients With Cancer of the Gastroesophageal Junction or Stomachtreatment2completed
NCT00991952
Irinotecan Hydrochloride With or Without Alvocidib in Treating Patients With Advanced Stomach or Gastroesophageal Junction Cancer That Cannot Be Removed By Surgerytreatment2completed
NCT05856500
A Study of Creatine Combined With Curcumin in the Intervention of Early Cachexia in Upper Gastrointestinal TumorsNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT00064259
A Phase I/II Study of Oblimersen Plus Cisplatin and Fluorouracil in Gastric & Esophageal Junction Cancertreatment1 / 2terminated
NCT04267575
Canady Helios Cold Plasma Scalpel Treatment at the Surgical Margin and Macroscopic Tumor SitesNo drug interventionstreatmentNot Availableunknown_status
NCT04267549
Conversion Therapy of Sintilimab in Combination With Apatinib and Chemotherapy in Stage IV Gastric Cancertreatment2active_not_recruiting
NCT00103324
S0413 Lapatinib in Treating Patients With Locally Advanced or Metastatic Stomach Cancertreatment2completed
NCT00028496
Vaccine Therapy With or Without Sargramostim in Treating Patients With Advanced or Metastatic Cancertreatment1completed
NCT03618758
Intraperitoneal Paclitaxel Plus Systemic mFOLFOX6treatment1 / 2completed
NCT03222258
Prospective Cohort Study Depending on the Use of Palliative Care for Advanced Stage of Cancer PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT03368963
TAS102 in Combination With NAL-IRI in Advanced GI Cancerstreatment1 / 2recruiting
NCT05301465
Predictive Role of Circulating Angiogenic Factors for Second-line Paclitaxel and Ramucirumab.No drug interventionsNot AvailableNot Availableunknown_status
NCT00062374
Irinotecan and Cisplatin in Treating Patients Who Are Undergoing Surgery For Locally Advanced Cancer of the Stomach or Gastroesophageal Junctiontreatment2completed
NCT01846520
Family Caregiver Palliative Care Intervention in Supporting Caregivers of Patients With Stage II-IV Gastrointestinal, Gynecologic, Urologic and Lung CancersNo drug interventionssupportive_careNot Availablecompleted
NCT05204173
Efficacy and Safety of Sintilimab Combined Intraperitoneal and Intravenous Paclitaxel Plus Oral S-1 in Gastric Cancer Patients With Peritoneal Metastasistreatment2unknown_status
NCT06519591
Systemic Application of Cadonilimab, LM-302, and S-1 Combined With Intraperitoneal Infusion of Paclitaxel for the Treatment of Claudin 18.2-positive Gastric Cancer With Peritoneal Metastasistreatment2recruiting
NCT00089362
Alvespimycin Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumorstreatment1completed
NCT00006389
Bryostatin 1 and Cisplatin in Treating Patients With Metastatic or Unresectable Stomach Cancertreatment2completed
NCT00982592
Combination Chemotherapy With or Without Vismodegib in Treating Patients With Advanced Stomach Cancer or Gastroesophageal Junction Cancertreatment2completed
NCT03755440
PD-1 Antibody in EBV Positive Metastatic Gastric Cancer Patients.treatment2completed
NCT02344810
C-Met Inhibitor AMG 337, Oxaliplatin, Leucovorin Calcium, and Fluorouracil in Treating Patients With Advanced Stomach or Esophageal Cancertreatment1 / 2withdrawn
NCT00031681
7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007)treatment1completed
NCT03154190
Health Care Coach Support in Reducing Acute Care Use and Cost in Patients With CancerNo drug interventionshealth_services_researchNot Availableunknown_status
NCT01191684
Vaccine Therapy in Treating Patients With Colorectal, Stomach, or Pancreatic Cancertreatment1completed
NCT00397384
Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancertreatment1completed
NCT04599179
SEMS and GastroenterostomyNo drug interventionsNot AvailableNot Availablecompleted
NCT01637805
Clinical Safety and Preliminary Efficacy of AAV-DC-CTL Treatment in Stage IV Gastric CancerNo drug interventionssupportive_care1unknown_status
NCT02291211
S-1 Combined Cisplatin HIPEC for Palliative Operation Gastric Cancer of Stage IV Limited Peritoneal Metastasistreatment2unknown_status
NCT02890511
A Study DHP107, a Novel Oral Paclitaxel Formulation, in Patients With Advanced Solid Tumours or Gastric Cancertreatment1 / 2completed
NCT04592211
Pembrolizumab, Olaparib, Recurrent/Advanced Gastric and Gastro-esophageal Junction(GEJ) Cancer With HRR Mutation and MSStreatment1 / 2unknown_status
NCT02333188
Genetic Analysis-Guided Dosing of FOLFIRABRAX in Treating Patients With Advanced Gastrointestinal Cancertreatment1completed
NCT03159585
To Evaluate the Efficacy of NY-ESO-1-specific T Cell Receptor Affinity Enhancing Specific T Cell in Solid TumorsNo drug interventionstreatment1completed
NCT01939275
64Cu DOTA-Trastuzumab PET/CT in Studying Patients With Gastric CancerNo drug interventionsdiagnosticNot Availableactive_not_recruiting
NCT04563975
Efficacy and Safety of Toripalimab Combined With Docetaxel or Nab-paclitaxel in Patients With Advanced Gastric Cancertreatment2unknown_status
NCT01643499
Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignanciestreatment1completed
NCT01231399
Everolimus and Combination Chemotherapy in Treating Patients With Metastatic Stomach or Esophageal Cancertreatment1 / 2completed
NCT00084617
Phase II Study of Oxaliplatin, Irinotecan, and Capecitabine in Advanced Gastric/Gastroesophageal Junction Carcinomatreatment2completed
NCT05319639
Phase I/II Study of the Combination of Irinotecan and POF (POFI) and Tislelizumabtreatment1 / 2recruiting
NCT00004074
Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neutreatment1completed
NCT04168931
Trastuzumab to Patients With Advanced Gastric Cancer With HER2 Positive Expression in CTCtreatment2terminated
NCT01839773
Phase 3 Study to Compare Efficacy and Safety of DHP107 vs. Taxol® in Patients With Metastatic or Recurrent Gastric Cancertreatment3completed
NCT03701373
Maintenance Treatment With S-1 in Gastric Cancer Patientstreatment2unknown_status
NCT06342427
Stomach Cancer Exosome-based DetectionNo drug interventionsNot AvailableNot Availablecompleted
NCT00607594
Saracatinib in Treating Patients With Locally Advanced or Metastatic Stomach or Gastroesophageal Junction Cancertreatment2completed
NCT00087191
EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung CancerdiagnosticNot Availableterminated
NCT00068380
A Phase II Trial of STI571 in the Treatment of Metastatic Gastric Cancertreatment2completed
NCT01178944
Pralatrexate and Oxaliplatin in Treating Patients With Unresectable or Metastatic Esophageal, Stomach, or Gastroesophageal Junction Cancertreatment2completed
NCT01705340
Akt Inhibitor MK2206, Lapatinib Ditosylate, and Trastuzumab in Treating Patients With Locally Advanced or Metastatic HER2-Positive Breast , Gastric, or Gastroesophageal Cancer That Cannot Be Removed By Surgerytreatment1terminated
NCT00084604
Irinotecan, Cisplatin, and Bevacizumab in Treating Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinomatreatment2completed
NCT01612546
Pilot Trial of CRLX101 in Treatment of Patients With Advanced or Metastatic Stomach, Gastroesophageal, or Esophageal Cancer That Cannot be Removed by Surgerytreatment2completed
NCT06157892
A Study of Disitamab Vedotin Alone or With Other Anticancer Drugs in Solid Tumorstreatment1 / 2recruiting
NCT06585488
A First-in-human Study of BGB-53038, a Pan-KRAS Inhibitor, Alone or in Combinations in Participants with Advanced or Metastatic Solid Tumors with KRAS Mutations or Amplificationtreatment1not_yet_recruiting
NCT06592287
The Combination of Adebrelimab, Apatinib, and Lrinotecan Liposome for Second-line Treatment of Advanced Gastric Cancertreatment1 / 2not_yet_recruiting
NCT01248403
A Randomized, Double Blind Study Evaluating Paclitaxel With and Without RAD001 in Patients With Gastric Carcinoma After Prior Chemotherapytreatment3completed
NCT02038621
The Maintenance Therapy of Capecitabine of Advanced Gastric Cancertreatment2unknown_status
NCT00845884
Phase I/II Study of Weekly Docetaxel and Cisplatin Together With Capecitabine and Bevacizumab in Advanced Gastric Cancertreatment1 / 2unknown_status
NCT03579784
Biomarker-oriented Study of Durvalumab (MEDI4736) in Combination With Olaparib and Paclitaxel in Gastric Cancertreatment2active_not_recruiting
NCT00879333
Safety and Efficacy of RAD001 (Everolimus) Monotherapy Plus Best Supportive Care in Patients With Advanced Gastric Cancer (AGC)treatment3completed
NCT05028933
IMC001 for Clinical Research on Advanced Digestive System MalignanciesNo drug interventionstreatment1recruiting
NCT00854854
Efficacy Study of TKcell in Advanced Gastric Cancertreatment1 / 2unknown_status
NCT01152853
PF-00299804 Monotherapy in Patients With HER-2 Positive Advance Gastric Cancertreatment2completed
NCT03350477
Bioinformation Therapy for Gastric CancerNo drug interventionstreatment2 / 3completed
NCT06486545
Liposomal Irinotecan Combination Regimen for Second-line Treatment of Advanced Gastric CancertreatmentNot Availablenot_yet_recruiting
NCT01946061
A Phase II Trial of Adjuvant Chemotherapy With S-1 Plus Oxaliplatin for Locally Advanced Gastric Cancertreatment2terminated
NCT04286711
Clinical Study of Albumin-paclitaxel Combined With Apatinib and Camrelizumab in Advanced Gastric Cancertreatment1 / 2unknown_status
NCT03255811
Clinical Study on Treatment of Apatinib Mesylate in First-line Maintenance of Advanced Gastric CancertreatmentNot Availableunknown_status
NCT06346093
Fecal Microbiota Transplantation (FMT) in Patients With Advanced Gastric CancerNo drug interventionstreatmentNot Availablerecruiting
NCT03954756
Exploratory Clinical Study of Apatinib and PD-1 in Treating Advanced Gastric Cancertreatment2unknown_status
NCT00565370
Capecitabine and Cisplatin (XP)+Sorafenib in Advanced Gastric Cancer (AGC): Sorafenib+XPtreatment1 / 2completed
NCT01471470
Efficacy of Docetaxel, Capecitabine, Cisplatin, and Bevacizumab in Patients With Unresectable Advanced Gastric Cancertreatment2completed
NCT01206218
Evaluation of Customized Treatment According to BRCA1 Assessment in Patients With Advanced Gastric CancerNo drug interventionstreatment2 / 3unknown_status
NCT01047618
Venous Thromboembolism in Advanced Gastric Cancer PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT02072317
Paclitaxel Plus Raltitrexed Plug Compare With Taxol Second-line Treatment for Advanced Gastric Cancertreatment2unknown_status
NCT03564834
Laparoscopic Versus Open Gastrectomy for Elderly Local Advanced Gastric Cancer PatientsNo drug interventionstreatment2unknown_status
NCT00519324
Efficacy and Safety of Everolimus (RAD001) in Patients With Advanced Gastric Cancertreatment2completed
NCT05649163
Real-world Study of HER2-overexpressed Advanced Solid Tumors After Progression of First-line Standard TherapyNot AvailableNot Availablenot_yet_recruiting
NCT01015339
Paclitaxel Plus Capecitabine With Capecitabine Maintenance Treatment in Metastatic Adenocarcinoma of the Stomach or Esophagogastric Junctiontreatment3unknown_status
NCT03449966
Comparison of Ability of pCLE and WLE for Diagnosis and Cancer Tissue Acquisition in Advanced Gastric Cancer After Chemotherapy StatusNo drug interventionsdiagnosticNot Availableunknown_status
NCT01049620
RAD001 in Combination With Capecitabine and Oxaliplatin (XELOX) in Patients With Advanced Gastric Cancer: RAD001+XELOXtreatment1completed
NCT01042782
Phase I Study of Daily RAD001 in Combination With Mitomycin C in Patients With Advanced Gastric Cancer or Cancer of the Esophagogastric Junctiontreatment1completed
NCT01136031
Paclitaxel and Irinotecan in Advanced Gastric Cancertreatment1 / 2completed
NCT06376773
Neoadjuvant Treatment Based on Gastric Cancer Molecular Subtyping.No drug interventionsNot AvailableNot Availablecompleted
NCT00842491
Study of Endostar With Cisplatin and Capecitabine as 1st Line Treatment in the Advanced Gastric Cancertreatment2completed
NCT05076591
IMM2902, a HER2/SIRPα Bispecific mAb-Trap Antibody-receptor Fusion Protein, in Patients With HER2-expressing Advanced Solid TumorsNo drug interventionstreatment1recruiting
NCT02952729
Study of Antibody Drug Conjugate in Patients With Advanced Breast Cancer Expressing HER2No drug interventionstreatment1completed
NCT04890392
Tislelizumab Combined With S-1 Plus Oxaliplatin as a Neoadjuvant Treatment in Patients With GC/GEJCtreatment2unknown_status
NCT00842244
Study Of Axitinib In Combination With Cisplatin And Capecitabine In Patients With Advanced Gastric Cancertreatment1completed
NCT03137004
Docetaxel and S-1 Combination Therapy as Second-line Treatment for Advanced Gastric Cancertreatment2unknown_status
NCT01503372
FLO +/- Pazopanib as First-line Treatment in Advanced Gastric Cancertreatment2completed
NCT01238055
Sunitinib + Docetaxel as Second-line Treatment in Gastric Cancertreatment2completed
NCT02071043
Trial of Xeloda and Oxaliplatin (XELOX) as Neo-adjuvant Chemotherapy Followed by Surgery in Advanced Gastric Cancer Patients With Para-aortic Lymph Node Metastasistreatment2completed
NCT00821990
Second-line Therapy Versus Supportive Care for Pretreated Advanced Gastric CancerNo drug interventionstreatment3completed
NCT00743964
Phase II Study of Epirubicin, Cisplatin and Capecitabine (ECX) Versus Cisplatin and Capecitabine (CX) for Advanced Gastric Cancer (AGC)treatment2completed
NCT04195828
Camrelizumab Combined With Apatinib Mesylate Tablets, Nab-paclitaxel and S-1 in the Treatment of Locally Advanced Gastric Cancertreatment2active_not_recruiting
NCT02123407
Clinical Study on the Harvesting Lymph Nodes With Carbon Nanoparticles for Advanced Gastric CancerNo drug interventionstreatment3unknown_status
NCT02451956
Study of AZD5363 in Combination With Paclitaxel, in Advanced Gastric Adenocarcinoma Patients Harboring PIK3CA Mutation and/or PIK3CA Amplification as a Second-line Chemotherapytreatment2completed
NCT03609359
Lenvatinib and Pembrolizumab Simultaneous Combination Studytreatment2completed
NCT06432075
Neoantigen Reactive T Cells c for Chinese Patients With Advanced Gastric CancerNo drug interventionstreatment0not_yet_recruiting
NCT00992199
Randomized Controlled Trials on Adjuvant Intraperitoneal Chemotherapy for Resectable Local Advanced Gastric Cancerprevention2unknown_status
NCT01441336
Laparoscopic Gastrectomy for Advanced Gastric CancerNo drug interventionstreatment2completed
NCT01851941
A Phase II Trial of Perioperative Chemotherapy With Oxaliplatin, 5-Fluorouracil, Leucovorin(MODIFIED FOLFOX6) in Patients With Locally Advanced Operable Gastric Cancertreatment2completed
NCT04385641
Study on the Safety and Effectiveness of UCB-NK Cell Infusion in the Treatment of Advanced Gastric Cancer and Gastroesophageal CancerNo drug interventionstreatmentNot Availableunknown_status
NCT02935634
A Study to Test Combination Treatments in Participants With Advanced Gastric Cancertreatment2completed
NCT04182724
Camrelizumab, Apatinib and Nab-paclitaxel as Second-line Treatment in Advanced Gastric Cancertreatment1 / 2unknown_status
NCT03393416
A Phase I Clinical Study for Evaluating the Safety of MASCT-I in Advanced Soild Tumortreatment1unknown_status
NCT02142322
Perioperative mFOLFOX-6 in Locally Advanced Gastric CancerNo drug interventionstreatment2completed
NCT01084330
Phase II Trial of AUY922 vs. Comparators in Advanced Gastric Cancertreatment2completed
NCT04799548
A Phase II Study of TACE Plus PD-1 Antibody in the Locally Advanced Stomach Adenocarcinomatreatment2recruiting
NCT02873520
Precision Cell Immunotherapy Combined With Chemotherapy in Advanced Gastric CancerNo drug interventionstreatment1 / 2unknown_status
NCT00428220
A Continuation Study Using Sunitinib Malate For Patients Leaving Treatment On A Previous Sunitinib Study.treatmentNot Availablecompleted
NCT00915382
Trial of 3-weekly Versus 5-weekly Schedule of S-1 Plus Cisplatin in Gastric Cancer: SOStreatment3completed
NCT03223376
A Phase III Study of Fruquintinib in Combination With Paclitaxel in Second Line Gastric Cancer(FRUTIGA)treatment3unknown_status
NCT05584592
A Randomized Controlled Trial of Integrated Early Palliative Care for Advanced Gastric Cancer PatientsNo drug interventionsotherNot Availablerecruiting
NCT03286244
Second-line CM082 Combined With Paclitaxel For Patients With Advanced Gastric Cancertreatment1unknown_status
NCT02560740
A Study of the Efficacy and Safety of PerOx Quench on the Prevention of Oxaliplatin Treatment Induced NeuropathyNo drug interventionspreventionNot Availableterminated
NCT01402401
Phase II of AUY922 in Second-line Gastric Cancer in Combination With Trastuzumab in HER2 Positive Patientstreatment2terminated
NCT00976768
Biweekly FOLFIRI in Advanced Gastric Cancer (AGC) With Failure of Prior Taxane, Fluoropyrimidine, and Cisplatintreatment2completed
NCT06169410
Ramucirumab Combined With Nab-paclitaxel, Lobaplatin, and S-1 in Neoadjuvant Transformation Therapy for Advanced Gastric Cancertreatment4recruiting
NCT03554395
Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Gastric CancerNo drug interventionstreatment2withdrawn
NCT01472250
A Prospective and Observational Cohort Study to Evaluate the Treatment Model and Medical Economics of Advanced Gastric Cancer Chemotherapy in Clinical Practice in ChinaNo drug interventionsNot AvailableNot Availablecompleted
NCT04797923
A Phase II Study of Conversion Surgery After IP Paclitaxel With XELOX Chemotherapy in AGC With Peritoneal Disseminationtreatment2unknown_status