Bacterial Endocarditis (DBCOND0031170)

Identifiers

Synonyms

Bacterial endocarditis / Endocarditis bacterial / Endocarditis, Bacterial / Endocarditis bacterial NOS / Bacterial endocarditis (disorder) / Endocarditis infective

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Ceftriaxone	A broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract.	Albumincarrier Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Penicillin-binding protein 2Btarget Glutamine synthetaseenzyme Solute carrier family 22 member 11target Solute carrier family 22 member 6target Organic anion transporter 3target Solute carrier family 15 member 1target ATP-dependent translocase ABCB1transporter
Clindamycin	A lincosamide antibiotic used to treat serious infections caused by susceptible anaerobic, streptococcal, staphylococcal, and pneumococcal bacteria.	Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Alpha-1-acid glycoprotein 1carrier ATP-dependent translocase ABCB1transporter 50S ribosomal protein L1target
Metronidazole	A nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections.	Oxygen-insensitive NADPH nitroreductasetarget Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1A1enzyme Anaerobic bacterial DNAtarget Protozoal DNAtarget ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme
Phenoxymethylpenicillin	A penicillin antibiotic used to prevent and treat mild to moderately severe infections in the respiratory tract, skin, and soft tissues.	Penicillin-binding protein 1Atarget MecA PBP2' (penicillin binding protein 2')target D-alanyl-D-alanine carboxypeptidase DacBtarget Penicillin acylasetarget Solute carrier family 15 member 1target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02979951	Fosfomycin I.v. for Treatment of Severely Infected Patients	No drug interventions	Not Available	Not Available	recruiting
NCT03048643	Combining Opioid Addiction Treatment Services With CARe for Infectious Endocarditis	No drug interventions	health_services_research	Not Available	completed
NCT00695903	Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia	Daptomycin Vancomycin	treatment	2	terminated
NCT05613933	Effectiveness of Antibiotic Prophylaxis of Infective Endocarditis for Invasive Dental Procedures in Patients With Prosthetic Heart Valves and/or History of Infective Endocarditis	No drug interventions	prevention	Not Available	not_yet_recruiting
NCT06563609	Multi-intervention Trial: Improving Inhospital ENDOcarditis Treatment and CARE	No drug interventions	supportive_care	Not Available	not_yet_recruiting
NCT00144885	IMAGE-Endocarditis: Resonance Magnetic Imaging at the Acute Phase of Endocarditis	No drug interventions	Not Available	Not Available	completed
NCT04840225	Anemia in Patients With Endocarditis	No drug interventions	Not Available	Not Available	unknown_status
NCT04222257	Short-course Antibiotic Treatment in Gram-positive Cocci Infective Endocarditis	No drug interventions	treatment	4	terminated
NCT05644990	T2MR PCR Detection of ESKAPE Pathogens in Patients With Pyogenic Spondylodiscitis and Infective Endocarditis	No drug interventions	Not Available	Not Available	recruiting
NCT05522764	Predictors of Infective Endocarditis Among Patients Managed for Staphylococcus Aureus Bacteremia, Particularly Staphylococcus Aureus Bacteriuria, and Time to Blood Culture Positivity	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT06250985	New Treatment of Cardiac Device Infections; Immediate Reimplantation After Removal of Infected System	No drug interventions	treatment	3	recruiting
NCT05152225	Neurological Complication of Infective Endocarditis: A Prospective Multi-site Cohort Study	No drug interventions	Not Available	Not Available	unknown_status
NCT03306225	Characterization of Endocarditis to Streptococci and Impact of the CMI on the Future of the Patients	No drug interventions	Not Available	Not Available	completed
NCT00401960	Daptomycin as an Adjuvant Agent in the Treatment of Enterococcal Native Valve Endocarditis.	Daptomycin	treatment	4	terminated
NCT00093067	Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus	Daptomycin	treatment	3	completed
NCT00524212	How to Improve Diagnosis in Infective Endocarditis	No drug interventions	Not Available	Not Available	completed
NCT06434012	Barts Endocarditis Research Registry	No drug interventions	Not Available	Not Available	active_not_recruiting