Vasomotor Symptoms Associated With Menopause (DBCOND0032090)

Identifiers

Synonyms

Vasomotor menopausal symptoms / Vasomotor Symptoms caused by Menopause / Menopausal Vasomotor Symptoms / Vasomotor Symptoms / Vasomotor Symptoms (VMS) / Efaffb79-f1b2-421d-a6aa-65ec8e42c33e caused by Menopause / Menopausal symptoms / Menopausal symptoms (finding) / Menopausal symptom (finding) / Menopausal symptoms NOS (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Estradiol	An estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.	Estrogen receptortarget Nuclear receptor subfamily 1 group I member 2target Sex hormone-binding globulincarrier Estrogen receptor betatarget Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 1A1enzyme Albumincarrier Fatty acid-binding protein, intestinalcarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 3transporter ATP-binding cassette sub-family C member 10transporter Solute carrier family 22 member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 1C1transporter Neuronal acetylcholine receptor subunit alpha-4target G-protein coupled estrogen receptor 1target ATP synthase subunit atarget Beclin-1target UDP-glucuronosyltransferase 2B15enzyme Catechol O-methyltransferaseenzyme UDP-glucuronosyltransferases (UGTs)enzyme Aromataseenzyme
Medroxyprogesterone acetate	A progestin used as a contraceptive and in the treatment of secondary amenorrhea, abnormal uterine bleeding, pain from endometriosis, endometrial and renal carcinomas, paraphilia in males, and GnRH-dependent precocious puberty.	Progesterone receptortarget Estrogen receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A1enzyme Albumincarrier ATP-dependent translocase ABCB1target GABA(A) Receptortarget ATP-dependent translocase ABCB1transporter
Paroxetine	A selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder.	Sodium-dependent serotonin transportertarget Sodium-dependent noradrenaline transportertarget 5-hydroxytryptamine receptor 2Atarget Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2B6enzyme Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Alpha-1 adrenergic receptorstarget Alpha-2 adrenergic receptorstarget Beta adrenergic receptortarget D(2) dopamine receptortarget Histamine H1 receptortarget Serotonin Receptorstarget Muscarinic acetylcholine receptortarget 5-hydroxytryptamine receptor 2Btarget D(1) dopamine receptortarget Cytochrome P450 2C19enzyme
Tibolone	For the relief of post-menopausal symptoms and for the prevention of osteoporosis .	Estrogen receptortarget Steryl-sulfataseenzyme 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1enzyme 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme Sulfotransferase 1A1enzyme Albumincarrier
Venlafaxine	A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression, generalized or social anxiety disorder, and panic disorder.	Sodium-dependent serotonin transportertarget Sodium-dependent noradrenaline transportertarget Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Sodium-dependent dopamine transportertarget ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05099159	A Study to Learn More About How Well Elinzanetant Works and How Safe it is for the Treatment of Vasomotor Symptoms (Hot Flashes) That Are Caused by Hormonal Changes Over 26 Weeks in Women Who Have Been Through the Menopause (OASIS-2)	Elinzanetant	treatment	3	completed
NCT00169299	Herbal Alternatives for Menopause Symptoms (HALT Study)	Black cohosh Estradiol Medroxyprogesterone acetate	treatment	4	unknown_status
NCT05042362	A Study to Learn More About How Well Elinzanetant Works and How Safe it is for the Treatment of Vasomotor Symptoms (Hot Flashes) That Are Caused by Hormonal Changes Over 26 Weeks in Women Who Have Been Through the Menopause	Elinzanetant	treatment	3	completed
NCT05030584	A Study to Learn More About How Well Elinzanetant Works and How Safe it is for the Treatment of Vasomotor Symptoms (Hot Flashes) That Are Caused by Hormonal Changes Over 52 Weeks in Women Who Have Been Through the Menopause	Elinzanetant	treatment	3	completed
NCT00234819	Study Evaluating Bazedoxifene/Conjugated Estrogen Combinations in Symptoms Associated With Menopause	Bazedoxifene Estradiol	treatment	3	completed
NCT00184795	Bleed Free Treatment of Menopausal Symptoms With New Ultra Low Dose Hormonal Combinations	Estradiol Norethisterone	treatment	3	completed
NCT06628388	Nurse-led Primary Healthcare Intervention Model in Women's Health Management in Hong Kong	No drug interventions	prevention	Not Available	not_yet_recruiting
NCT04209543	Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women (E4Comfort Study I)	Estetrol Progesterone	treatment	3	active_not_recruiting
NCT03512002	HIRREM Hot Flashes Study	No drug interventions	supportive_care	Not Available	completed
NCT05083884	A Survey About Hot Flashes in Women Going Through the Menopause	No drug interventions	Not Available	Not Available	completed
NCT00894543	MsFLASH-01: Escitalopram for Menopausal Symptoms in Midlife Women	Escitalopram	treatment	Not Available	completed
NCT00401245	The Effect Of Dose Titration And Dose Tapering On The Tolerability Of DVS SR In Women With Vasomotor Symptoms	Desvenlafaxine	treatment	3	completed
NCT00456898	Study Evaluating the Potential of DVS SR to Inhibit the CYP2D6 Pathway	Codeine Desvenlafaxine Paroxetine	treatment	1	completed
NCT01073397	Effect of Yoga on Objective and Subjective Menopausal Hot Flashes	No drug interventions	other	Not Available	completed
NCT05637671	Efficacy and Safety of Oxybutynin Versus Paroxetine in Aromatase Inhibitor-induced Vasomotor Symptoms	Oxybutynin Paroxetine	treatment	3	recruiting
NCT04808232	The Effect of Health Education and Progressive Muscle Relaxation Exercise on Vasomotor Symptoms and Sleep Problems With Perimenopausal Women	No drug interventions	prevention	Not Available	completed
NCT00683800	Study Evaluating The Safety And Efficacy Of Desvenlafaxine Succinate For Vasomotor Symptoms In Menopausal Women	Desvenlafaxine	treatment	3	completed
NCT00446199	Low-dose Hormone Therapy for Relief of Vasomotor Symptoms	Drospirenone Estradiol	treatment	3	completed
NCT00651599	Treatment of Vasomotor Symptoms in Korean Post Menopausal Women	Drospirenone Estradiol	treatment	3	completed
NCT02653417	Study to Evaluate the Safety and Efficacy of RAD1901 in Postmenopausal Women With Moderate to Severe Vasomotor Symptoms	Elacestrant	treatment	2	terminated
NCT01353963	Desvenlafaxine Succinate (Pristiq): Postmarketing Surveillance Study Among Filipino Patients	Desvenlafaxine	Not Available	Not Available	terminated
NCT05418426	A Phase 1, Open-Label, Parallel Group Study to Evaluate the Pharmacokinetics and Safety of DARE-HRT1 in Healthy PostMenopausal Women	Estradiol Progesterone	other	1	completed
NCT00421031	Study Evaluating the Safety & Efficacy of DVS-223 SR for Relief of Vasomotor Symptoms Associated With Menopause	Desvenlafaxine	treatment	3	completed
NCT01452373	Dehydroepiandrosterone (DHEA) + Acolbifene Against Vasomotor Symptoms (Hot Flushes) in Postmenopausal Women	Acolbifene Prasterone	treatment	3	completed
NCT05813067	Herbal Nutraceutical Supplementation on Vasomotor Symptoms in Menopausal Women	No drug interventions	supportive_care	Not Available	completed
NCT06204250	A Study to Assess Safety and Tolerability of GS1-144 in Healthy Volunteers	No drug interventions	other	1	recruiting
NCT00906308	A Study of MF101 in Postmenopausal Women	MF101	treatment	3	unknown_status
NCT00560833	Dose-Finding Safety and Efficacy Trial of Org50081 (Esmirtazapine) in the Treatment of Vasomotor Symptoms (46101/P06459/MK-8265-012)	Esmirtazapine	treatment	3	completed
NCT01052454	Mindfulness-Based Stress Reduction for Hot Flashes	No drug interventions	treatment	0	completed
NCT00332553	Study of Hot Flashes and Night Sweats in Postmenopausal Women Receiving Combination Raloxifene and Oral Estrogen	Estradiol Medroxyprogesterone acetate Raloxifene	prevention	2	completed
NCT00356447	Safety/Efficacy Study of Drospirenone/Estradiol to Treat Postmenopausal Chinese Women With Vasomotor Symptoms.	Drospirenone Estradiol	treatment	3	completed
NCT02907983	Stellate Ganglion Blockade in Post-Menopausal Women	Bupivacaine Sodium chloride	supportive_care	2	suspended
NCT01276028	Acupuncture in Menopause	No drug interventions	treatment	Not Available	completed
NCT00535288	Dose-Finding Safety and Efficacy Trial of Org 50081 (Esmirtazapine) in the Treatment of Vasomotor Symptoms (177001/P06472/MK-8265-013)	Esmirtazapine	treatment	3	completed
NCT02202707	Vasomotor Symptoms and Cardiovascular Control	Gabapentin	treatment	Not Available	withdrawn
NCT05033886	A Study of Fezolinetant to Treat Hot Flashes in Women Going Through Menopause	Fezolinetant	treatment	3	completed
NCT01117857	Duloxetine for Menopausal Depression	Duloxetine	treatment	4	completed
NCT04090957	Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women	Estetrol	treatment	3	completed
NCT06393673	A Study to Find the Best Dose of HS-10384 to Treat Vasomotor Symptoms in Postmenopausal Women	No drug interventions	treatment	2	not_yet_recruiting
NCT05367973	Study of DARE-HRT1 Over 12 Weeks in Healthy PostMenopausal Women	No drug interventions	treatment	1 / 2	completed
NCT00397176	Study Evaluating Safety, Tolerability, and PK of DVS SR in Healthy Japanese Women	Desvenlafaxine	treatment	1	completed
NCT01178892	MsFLASH-02: Interventions for Relief of Menopausal Symptoms: A 3-by-2 Factorial Design Examining Yoga, Exercise, and Omega-3 Supplementation	No drug interventions	treatment	Not Available	completed
NCT05312567	FP-101 Versus Placebo in the Treatment of Menopausal Vasomotor Symptoms	No drug interventions	treatment	2	completed
NCT03122301	Effects of Stellate Ganglion Block on Hot Flashes in Hispanic Women With Breast Cancer	Bupivacaine	supportive_care	2	terminated
NCT00472004	Study Comparing 17B Estradiol/TMG CC 1mg Vs. Tibolone In Postmenopausal Women	Estradiol Tibolone	treatment	4	completed
NCT02803268	A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Multiple Doses of MT-8554 in Female Subjects Experiencing Vasomotor Symptoms	Elismetrep	other	1	completed
NCT06122181	Study of HS-10384 in Participants of Chinese Postmenopausal Women	No drug interventions	treatment	1	recruiting
NCT05850338	Determination of the Effects of Autogenic Relaxation Exercise and Cold Pillow Application on Vasomotor Symptom Control and Quality of Life in Postmenopausal Women	No drug interventions	supportive_care	Not Available	completed
NCT04080297	Dose Escalation Study in Female Subjects With Breast Cancer Receiving Aromatase Inhibitor or Tamoxifen	No drug interventions	treatment	1	completed
NCT03518138	Safety/Efficacy of Q-122 in Breast Cancer Patients Taking Tamoxifen or Aromatase Inhibitor	No drug interventions	treatment	2	completed
NCT02049164	Safety and Efficacy Study of AR08 for the Treatment of Vasomotor Symptoms (VMS)	No drug interventions	treatment	2	terminated
NCT03541200	Long-term Safety and Efficacy Study of MT-8554 in Postmenopausal Women With Vasomotor Symptoms	Elismetrep	treatment	2	completed