Recurrent Genital Herpes (RGH) (DBCOND0032971)

Identifiers

Synonyms

Recurrent Genital Herpes

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acyclovir	A guanosine analog used to treat herpes simplex, varicella zoster, herpes zoster.	DNA polymerase catalytic subunittarget DNA polymerase catalytic subunittarget Solute carrier family 22 member 1transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Ileal sodium/bile acid cotransportertransporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Thymidine kinaseenzyme Guanylate kinaseenzyme Nucleoside diphosphokinaseenzyme Pyruvate Kinasesenzyme Creatine Kinasesenzyme Phosphoglycerate Kinasesenzyme Succinyl-CoA Synthetasesenzyme Phosphoenolpyruvate Carboxykinasesenzyme Adenylosuccinate Synthetasesenzyme Albumincarrier
Famciclovir	A nucleoside analog DNA polymerase inhibitor used for the treatment of recurrent cold sores and genital herpes in healthy patients and patients with HIV, and to manage herpes zoster.	DNA polymerase catalytic subunittarget Aldehyde oxidaseenzyme
Valaciclovir	An guanine nucleoside antiviral used to treat herpes exacerbations.	Thymidine kinasetarget DNA polymerase catalytic subunittarget Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Organic anion transporter 3transporter Solute carrier family 22 member 6transporter Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter Ileal sodium/bile acid cotransportertransporter Guanylate kinaseenzyme Thymidine kinaseenzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00219310	RELIEF: Randomized Episodic Versus Long-Term Suppression Experience With Famciclovir	Famciclovir	treatment	4	completed
NCT04979975	Evaluating Safety and Efficacy of Repeat Doses of UB-621in Adult Patients With Recurrent Genital Herpes	No drug interventions	treatment	2	not_yet_recruiting
NCT00171990	Efficacy and Safety of Oral Famciclovir in Patients With Active Recurrent Genital Herpes	Famciclovir	treatment	3	completed
NCT04714060	UB-621, a New Type of Anti-herpes Simplex Virus (HSV) Monoclonal Antibody for the Use in the Treatment of Adult Recurrent HSV-2 Infections of the Genitals	No drug interventions	treatment	2	not_yet_recruiting