Detrusor Hyperreflexia (DBCOND0033407)

Identifiers

Synonyms

Detrusor Overactivity / Detrusor, Overactive / Detrusor Muscle Hyperactivity / Detrusor Function, Overactive / Overactive Detrusor Function / Overactive Detrusor / Detrusor Hyperreflexia of Bladder / Detruser overactivity / Detrusor spasm / Detrusor hyperreflexia / Detrusor overactivity (disorder) / Neurogenic detrusor overactivity (disorder) / Overactive bladder / Overactive bladder (disorder) / Hypertonic bladder / Hyperactive bladder / Urinary Bladder, Overactive / Hypertonicity of bladder / Low compliance bladder (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Atropine	A muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs.	Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target Muscarinic acetylcholine receptor M3target Glycine receptor subunit alpha-1target Neuronal acetylcholine receptor subunit alpha-4target Neuronal acetylcholine receptor subunit beta-2target Bile salt export pumptransporter Alpha-1-acid glycoprotein 1carrier
Oxybutynin	An antimuscarinic agent that reduces detrusor muscle activity, relaxing the bladder and preventing the urge to void.	Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A5enzyme Alpha-1-acid glycoprotein 1carrier Albumincarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04693897	Effect of beta3-adrenoceptor Agonist on Patients With Overactive Bladder and as a Urinary Biomarker	Mirabegron Solifenacin	Not Available	Not Available	unknown_status
NCT04543552	A Comparative Analysis of Portable Bladder Scanner to Determine Age/ Volume Specific Accuracy in 0-6 Years of Children	No drug interventions	Not Available	Not Available	completed
NCT00822913	Botulinum A Toxin in Patients With Parkinson's Disease	Diphenhydramine	treatment	4	unknown_status
NCT05572918	Developing a Simple Test to Diagnose Overactive Bladder	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT01003457	Ultrasonographic Bladder Wall Thickness and Different Forms of Detrusor Overactivity	No drug interventions	Not Available	Not Available	completed
NCT00373789	Refractory Urge Incontinence and Botox Injections	Botulinum toxin type A	treatment	3	terminated
NCT00478881	A Study To Assess If 10 mg Vardenafil (BAY38-9456) Taken Twice Daily For 6 Weeks Has An Effect On Bladder Function	Vardenafil	treatment	2	completed
NCT00678795	A Parallel Group Study to Compare Sativex® With Placebo in the Treatment of Detrusor Overactivity in Patients With Multiple Sclerosis	Cannabidiol Dronabinol	supportive_care	3	completed
NCT04978714	USI and/or DO in Women With Cystocele Before and After Cystocele Repair	No drug interventions	Not Available	Not Available	completed
NCT01850706	UNGF Assessment in Patients With Detrusor Overactivity Undergoing Sacral Neuromodulation	No drug interventions	Not Available	Not Available	completed
NCT01093534	Study of 2 Doses of Solifenacin Succinate in Female Subjects With Overactive Bladder.	Solifenacin	basic_science	4	completed
NCT01023269	Efficacy Study of Pudendal Neuromodulation for the Treatment of Neurogenic Overactive Bladder	No drug interventions	treatment	Not Available	terminated
NCT03727711	TPTNS: Home vs Hospital Treatment for Overactive Bladder	No drug interventions	treatment	Not Available	unknown_status
NCT03033355	Central Nervous System Changes Following BotulinumtoxinA Injection in the Bladder	Botulinum toxin type A	Not Available	Not Available	completed
NCT04981054	BO and DO in Women With Cystocele Before and After Cystocele Repair	No drug interventions	Not Available	Not Available	completed
NCT01357980	Neurogenic Detrusor Overactivity Following Spinal Cord Injury or Multiple Sclerosis	Botulinum toxin type A	treatment	2	completed
NCT01796548	Extended-Release Oxybutynin for the Treatment of Neurogenic Detrusor Overactivity	Oxybutynin	treatment	4	terminated
NCT01530620	Efficacy and Tolerability of Propiverine Hydrochloride in Patients With Neurogenic Detrusor Overactivity	Propiverine	treatment	3	completed
NCT05895045	Yoga for Treatment of Overactive Bladder in Pediatric Patients	No drug interventions	treatment	Not Available	recruiting
NCT01629433	Onabotulinumtoxina Intradetrusorial Injections and NGF Expression	No drug interventions	Not Available	Not Available	completed
NCT06212661	Migraine Medication Effects on Urinary Symptoms	Atogepant Botulinum toxin type A Eptinezumab Erenumab Fremanezumab Galcanezumab Rimegepant Ubrogepant	Not Available	Not Available	enrolling_by_invitation
NCT03451175	Reproductibility of Cystometry in Multiple Sclerosis Patient	No drug interventions	Not Available	Not Available	completed
NCT05977634	Transcutaneous Tibial Nerve Stimulation for Idiopathic Overactive Bladder	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT03388086	Efficacy of Two Onabotulinum Toxin Doses	No drug interventions	Not Available	Not Available	completed
NCT01192568	Safety and Efficacy Evaluation of Oxybutynin Topical Gel In Children With Neurogenic Bladder	Oxybutynin	treatment	4	completed
NCT01837654	Plantarflexion Reduces Urgency and Peak Detrusor Pressure in Patients With Detrusor Overactivity	No drug interventions	treatment	Not Available	completed
NCT01408771	"Swallow my Urine Back" : Inhibition of Detrusor Overactivity by Swallowing Maneuver	No drug interventions	Not Available	Not Available	completed
NCT01781117	Prognostic Value of the Urinary Nerve Growth Factor in the Patients With Benign Prostatic Hyperplasia	No drug interventions	treatment	Not Available	completed
NCT02657057	Effects of Transcutaneous and Percutaneous PTNS on Idiopathic OAB	No drug interventions	treatment	Not Available	completed
NCT04270526	Minimizing Pain During Office Intradetrussor Botox Injection	No drug interventions	treatment	4	completed
NCT04197466	Comparison of Different Treatments for Overactive Bladder Syndrome	No drug interventions	treatment	Not Available	completed
NCT03080389	Sensitivity of Extended Cultures in Diagnosing Urinary Tract Infections	No drug interventions	Not Available	Not Available	terminated
NCT02009540	Botulinum Toxin in the Treatment of Idiopathic Detrusor Overactivity	Botulinum toxin type A	treatment	4	unknown_status
NCT00845338	Study of Darifenacin in Patients Suffering From Multiple Sclerosis and Neurogenic Detrusor Overactivity	Darifenacin	treatment	2	terminated
NCT00224016	Safety and Efficacy Study of Transdermal Oxybutynin to Treat Overactive Bladder With a Neurological Condition	Oxybutynin	treatment	4	completed
NCT00224029	A Study Evaluating Oxybutynin in Patients With Neurogenic Overactive Bladder Associated With a Neurological Condition	Oxybutynin	treatment	4	completed
NCT03755089	Oral vs Intravesical Analgesia for Office Bladder Botox Injections	Lidocaine Phenazopyridine	treatment	4	unknown_status
NCT00583219	Botulin-A Toxin Instillations and Overactive Bladder	Botulinum toxin type A Dimethyl sulfoxide	treatment	1 / 2	completed
NCT00667095	Over Active Bladder Instillation Study - Botox	Botulinum toxin type A Dimethyl sulfoxide	treatment	3	terminated