Atropine
Identification
- Name
- Atropine
- Accession Number
- DB00572
- Description
An alkaloid, originally from Atropa belladonna, but found in other plants, mainly solanaceae.
- Type
- Small Molecule
- Groups
- Approved, Vet approved
- Structure
Structure for Atropine (DB00572)
- Weight
- Average: 289.3694
Monoisotopic: 289.167793607 - Chemical Formula
- C17H23NO3
- Synonyms
- (±)-atropine
- (±)-hyoscyamine
- Atropin
- Atropina
- Atropine
- Atropinum
- dl-Hyoscyamine
- dl-tropyltropate
- Tropine tropate
- External IDs
- NSC 61810
Pharmacology
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For the treatment of poisoning by susceptible organophosphorous nerve agents having anti-cholinesterase activity (cholinesterase inhibitors) as well as organophosphorous or carbamate insecticides.
- Associated Conditions
- Amblyopia
- Atrioventricular Heart Block
- Bradycardia
- Bronchospasm
- Crying
- Detrusor Hyperreflexia
- Excessive bronchial secretion
- Hypertonic uterine contraction
- Hypertonicity of the small intestine
- Ocular Inflammation
- Parkinsonism
- Peptic Ulcer
- Poisoning by parasympathomimetics (cholinergics)
- Poisoning caused by mushrooms
- Poisoning caused by organophosphate anticholinesterase nerve agents
- Poisoning caused by organophosphorus pesticides
- Pylorospasm
- Rhinorrhoea
- Sinus Bradycardia
- Spasms
- Toxic effect of organophosphate and carbamate
- Hypermobility of the colon
- Laughing
- Muscarinic side effects
- Contraindications & Blackbox Warnings
Contraindications & Blackbox WarningsWith our commercial data, access important information on dangerous risks, contraindications, and adverse effects.Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects- Pharmacodynamics
Atropine, a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters. Adequate doses of atropine abolish various types of reflex vagal cardiac slowing or asystole. The drug also prevents or abolishes bradycardia or asystole produced by injection of choline esters, anticholinesterase agents or other parasympathomimetic drugs, and cardiac arrest produced by stimulation of the vagus. Atropine may also lessen the degree of partial heart block when vagal activity is an etiologic factor. Atropine in clinical doses counteracts the peripheral dilatation and abrupt decrease in blood pressure produced by choline esters. However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure.
- Mechanism of action
Atropine binds to and inhibit muscarinic acetylcholine receptors, producing a wide range of anticholinergic effects.
Target Actions Organism AMuscarinic acetylcholine receptor M1 antagonistHumans AMuscarinic acetylcholine receptor M2 antagonistHumans AMuscarinic acetylcholine receptor M3 antagonistHumans AMuscarinic acetylcholine receptor M4 antagonistHumans AMuscarinic acetylcholine receptor M5 antagonistHumans UGlycine receptor subunit alpha-1 antagonistHumans UNeuronal acetylcholine receptor subunit alpha-4 Not Available Humans UNeuronal acetylcholine receptor subunit beta-2 Not Available Humans - Absorption
Atropine is rapidly and well absorbed after intramuscular administration. Atropine disappears rapidly from the blood and is distributed throughout the various body tissues and fluids.
- Volume of distribution
- Not Available
- Protein binding
The protein binding of atropine is 14 to 22% in plasma.
- Metabolism
Much of the drug is destroyed by enzymatic hydrolysis, particularly in the liver. From 13 to 50% is excreted unchanged in the urine.
- Route of elimination
Much of the drug is destroyed by enzymatic hydrolysis, particularly in the liver; from 13 to 50% is excreted unchanged in the urine.
- Half-life
3.0 ± 0.9 hours in adults. The half-life of atropine is slightly shorter (approximately 20 minutes) in females than males.
- Clearance
- Not Available
- Adverse Effects
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Oral, mouse: LD50 = 75 mg/kg. Symptoms of overdose includes widespread paralysis of parasympathetically innervated organs. Dry mucous membranes, widely dilated and nonresponsive pupils, tachycardia, fever and cutaneous flush are especially prominent, as are mental and neurological symptoms. In instances of severe intoxication, respiratory depression, coma, circulatory collapse and death may occur.
- Affected organisms
- Humans and other mammals
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcebutolol Atropine may increase the arrhythmogenic activities of Acebutolol. Aceclofenac The risk or severity of hypertension can be increased when Atropine is combined with Aceclofenac. Acemetacin The risk or severity of hypertension can be increased when Atropine is combined with Acemetacin. Acetazolamide Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Atropine. Acetophenazine Acetophenazine may increase the central nervous system depressant (CNS depressant) activities of Atropine. Acetyldigitoxin Acetyldigitoxin may increase the arrhythmogenic activities of Atropine. Acetylsalicylic acid The risk or severity of hypertension can be increased when Atropine is combined with Acetylsalicylic acid. Aclidinium The risk or severity of adverse effects can be increased when Atropine is combined with Aclidinium. Acrivastine The risk or severity of QTc prolongation can be increased when Acrivastine is combined with Atropine. Adenosine Atropine may increase the arrhythmogenic activities of Adenosine. 
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- Avoid alcohol.
- Take with food.
Products
Comprehensive & structured drug product infoFrom application numbers to product codes, connect different identifiers through our commercial datasets.Easily connect various identifiers back to our datasets- Product Ingredients
Ingredient UNII CAS InChI Key Atropine hydrochloride EUF58V826B 33952-38-4 OJIPQOWZZMSBGY-RIMUKSHESA-N Atropine sulfate 03J5ZE7KA5 5908-99-6 JPKKQJKQTPNWTR-CHYDPLAESA-N Atropine sulfate anyhdrous KAE4PSB0Z3 55-48-1 HOBWAPHTEJGALG-UHFFFAOYSA-N - Product Images
- International/Other Brands
- Anespin (Oriental Chemical Works) / Antol (Ying Yuan) / AtroPen (Meridian) / Atropt (Sigma) / Atrospan (Fischer) / Bellapan (Farmapol) / Dysurgal (MaxMedic) / Kintropine (Synpac-Kingdom) / Tromine (The Central)
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image ATROPEN Auto-Injector Injection 2 mg/0.7mL Intramuscular Meridian Medical Technologies, Inc. 2003-06-19 Not applicable US 
ATROPEN Auto-Injector Injection 0.25 mg/0.3mL Intramuscular Meridian Medical Technologies, Inc. 2004-09-17 Not applicable US ATROPEN Auto-Injector Injection 1 mg/0.7mL Intramuscular Meridian Medical Technologies, Inc. 2003-06-19 Not applicable US ATROPEN Auto-Injector Injection 2 mg/0.7mL Intramuscular Meridian Medical Technologies, Inc. 1973-05-15 Not applicable US ATROPEN Auto-Injector Injection 0.5 mg/0.7mL Intramuscular Meridian Medical Technologies, Inc. 2003-06-19 Not applicable US Atropine Solution / drops 10 mg/1mL Ophthalmic Akorn, Inc. 2014-07-18 Not applicable US Atropine Solution 1 % Ophthalmic Pharma Stulln Inc. 1994-12-31 Not applicable Canada 
Atropine Solution / drops 10 mg/1mL Ophthalmic Mwi 2015-03-23 Not applicable US Atropine Solution / drops 10 mg/1mL Ophthalmic A-S Medication Solutions 2014-07-18 Not applicable US Atropine 1% Solution / drops 1 % Ophthalmic Novartis Ophthalmics Novartis Pharmaceuticals (Canada) Inc 1987-12-31 2003-12-10 Canada - Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Atropine Sulfate Injection, solution 0.4 mg/1mL Endotracheal; Intramedullary; Intramuscular; Intravenous; Subcutaneous Accord Healthcare Inc. 2021-03-25 Not applicable US Atropine Sulfate Injection 0.1 mg/1mL Intravenous International Medication Systems, Limited 2021-02-16 Not applicable US - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image ยูเมด้า อะโทรปิน Solution บริษัท ยูเมด้า จำกัด 1999-09-21 2020-08-23 Thailand 
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image ATNAA atropine and pralidoxime chloride Auto-Injector Atropine (2.1 mg/0.7mL) + Pralidoxime chloride (600 mg/2mL) Kit Intramuscular Meridian Medical Technologies, Inc. 2002-01-17 Not applicable US Diban Cap Atropine sulfate anyhdrous (9.7 mcg) + Attapulgite (300 mg) + Hyoscyamine sulfate (0.0519 mg) + Opium (12 mg) + Pectin (71.4 mg) + Scopolamine (3.3 mcg) Capsule Oral Wyeth Ayerst Canada Inc. 1998-02-18 2001-01-30 Canada Diban Cap Atropine sulfate anyhdrous (9.7 mcg) + Attapulgite (300 mg) + Hyoscyamine sulfate (0.0519 mg) + Opium (12 mg) + Pectin (71.4 mg) + Scopolamine (3.3 mcg) Capsule Oral Ayerst Laboratories 1992-12-31 1999-04-12 Canada Diphenoxylate Hcl and Atropine Sulfate Atropine sulfate anyhdrous (0.025 mg/1) + Diphenoxylate hydrochloride (2.5 mg/1) Tablet Oral Stat Rx USA 1979-10-29 Not applicable US Diphenoxylate Hydrochloride and Atropine Sulfate Atropine sulfate anyhdrous (0.025 mg/1) + Diphenoxylate hydrochloride (2.5 mg/1) Tablet Oral A-S Medication Solutions 1977-11-17 Not applicable US 
Diphenoxylate Hydrochloride and Atropine Sulfate Atropine sulfate anyhdrous (0.025 mg/1) + Diphenoxylate hydrochloride (2.5 mg/1) Tablet Oral Cadinal Health 2010-10-15 2015-05-31 US Diphenoxylate Hydrochloride and Atropine Sulfate Atropine sulfate anyhdrous (0.025 mg/1) + Diphenoxylate hydrochloride (2.5 mg/1) Tablet Oral Ncs Health Care Of Ky, Inc Dba Vangard Labs 1977-11-17 Not applicable US Diphenoxylate Hydrochloride and Atropine Sulfate Atropine sulfate anyhdrous (0.025 mg/1) + Diphenoxylate hydrochloride (2.5 mg/1) Tablet Oral KAISER FOUNDATION HOSPITALS 2010-11-30 2017-08-31 US Diphenoxylate Hydrochloride and Atropine Sulfate Atropine sulfate anyhdrous (0.025 mg/1) + Diphenoxylate hydrochloride (2.5 mg/1) Tablet Oral Nucare Pharmaceuticals, Inc. 1977-11-17 Not applicable US Diphenoxylate Hydrochloride and Atropine Sulfate Atropine sulfate anyhdrous (0.025 mg/1) + Diphenoxylate hydrochloride (2.5 mg/1) Tablet Oral Rebel Distributors 2009-11-30 Not applicable US 
- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image ATROPIN GALEN 0,25 MG 10 AMPUL Atropine sulfate anyhdrous (0.25 mg) Solution Intramuscular; Intravenous; Subcutaneous GALEN İLAÇ SAN.VE TİC.A.Ş 2020-08-14 Not applicable Turkey 
ATROPIN GALEN 0,5 MG 10 AMPUL Atropine sulfate anyhdrous (0.5 mg) Solution Intramuscular; Intravenous; Subcutaneous GALEN İLAÇ SAN.VE TİC.A.Ş 2020-08-14 Not applicable Turkey ATROPIN GALEN 1 MG 10 AMPUL Atropine sulfate anyhdrous (1 mg) Solution Intramuscular; Intravenous; Subcutaneous GALEN İLAÇ SAN.VE TİC.A.Ş 2020-08-14 Not applicable Turkey Atropine Care Atropine sulfate anyhdrous (10 mg/1mL) Solution / drops Ophthalmic Akorn, Inc 1995-06-01 2008-06-01 US Atropine Sulfate Atropine sulfate anyhdrous (0.1 mg/1mL) Injection Parenteral Medical Purchasing Solutions, Llc 2000-06-01 Not applicable US Atropine Sulfate Atropine sulfate anyhdrous (0.1 mg/1mL) Injection Parenteral REMEDYREPACK INC. 2019-05-01 Not applicable US Atropine Sulfate Atropine sulfate anyhdrous (1 mg/1mL) Injection, solution Intramuscular; Intravenous; Subcutaneous General Injectables & Vaccines, Inc 2013-09-19 Not applicable US Atropine Sulfate Atropine sulfate anyhdrous (0.4 mg/1mL) Injection, solution Intramuscular; Intravenous; Subcutaneous Cardinal Health 2011-07-07 2018-10-31 US Atropine Sulfate Atropine sulfate anyhdrous (0.1 mg/1mL) Injection Parenteral International Medication Systems, Limited 2000-06-01 Not applicable US Atropine Sulfate Atropine sulfate anyhdrous (0.4 mg/0.5mL) Injection, solution Intramuscular; Intravenous; Subcutaneous AMERICAN REGENT, INC. 1992-11-01 2011-09-29 US
Categories
- ATC Codes
- S01FA01 — AtropineA03CB03 — Atropine and psycholeptics
- A03CB — Belladonna and derivatives in combination with psycholeptics
- A03C — ANTISPASMODICS IN COMBINATION WITH PSYCHOLEPTICS
- A03 — DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
- A — ALIMENTARY TRACT AND METABOLISM
- Drug Categories
- Adjuvants, Anesthesia
- Agents producing tachycardia
- Agents that produce hypertension
- Alimentary Tract and Metabolism
- Alkaloids
- Anti-Asthmatic Agents
- Antiarrhythmic agents
- Anticholinergic Agents
- Antimuscarinics Antispasmodics
- Atropine Derivatives
- Autonomic Agents
- Aza Compounds
- Azabicyclo Compounds
- Belladonna Alkaloids
- Belladonna Alkaloids, Tertiary Amines
- Belladonna and Derivatives, Plain
- Bronchodilator Agents
- BSEP/ABCB11 Substrates
- Cardiovascular Agents
- Central Nervous System Agents
- Cholinergic Agents
- Drugs for Functional Gastrointestinal Disorders
- Moderate Risk QTc-Prolonging Agents
- Muscarinic Antagonists
- Mydriatics
- Mydriatics and Cycloplegics
- Neurotransmitter Agents
- Ophthalmologicals
- Parasympatholytics
- Peripheral Nervous System Agents
- QTc Prolonging Agents
- Respiratory System Agents
- Sensory Organs
- Solanaceous Alkaloids
- Tropanes
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as tropane alkaloids. These are organic compounds containing the nitrogenous bicyclic alkaloid parent N-Methyl-8-azabicyclo[3.2.1]octane.
- Kingdom
- Organic compounds
- Super Class
- Alkaloids and derivatives
- Class
- Tropane alkaloids
- Sub Class
- Not Available
- Direct Parent
- Tropane alkaloids
- Alternative Parents
- Beta hydroxy acids and derivatives / Piperidines / N-alkylpyrrolidines / Benzene and substituted derivatives / Trialkylamines / Carboxylic acid esters / Amino acids and derivatives / Monocarboxylic acids and derivatives / Azacyclic compounds / Primary alcohols show 4 more
- Substituents
- Alcohol / Amine / Amino acid or derivatives / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Beta-hydroxy acid / Carbonyl group / Carboxylic acid derivative / Carboxylic acid ester show 18 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- racemate (CHEBI:16684) / Tropane alkaloids, Alkaloids, Tropan alkaloids (C01479)
Chemical Identifiers
- UNII
- 7C0697DR9I
- CAS number
- 51-55-8
- InChI Key
- RKUNBYITZUJHSG-SPUOUPEWSA-N
- InChI
- InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
- IUPAC Name
- (1R,3R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate
- SMILES
- CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)C1=CC=CC=C1
References
- Synthesis Reference
Pei-Chang Wu, Hsi-Kung Kuo, Po-Chiung Fang, Jong-Jer Lee, Chih-Hsin Chen, "Low-concentration atropine solution for preventing myopia progression and preparing method thereof." U.S. Patent US20070254914, issued November 01, 2007.
US20070254914- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0014712
- KEGG Drug
- D00113
- KEGG Compound
- C01479
- PubChem Compound
- 174174
- PubChem Substance
- 46507540
- ChemSpider
- 10194105
- BindingDB
- 50403547
- 1223
- ChEBI
- 78734
- ChEMBL
- CHEMBL517712
- Therapeutic Targets Database
- DAP000377
- PharmGKB
- PA448505
- Guide to Pharmacology
- GtP Drug Page
- PDBe Ligand
- OIN
- RxList
- RxList Drug Page
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Atropine
- AHFS Codes
- 12:08.08 — Antimuscarinics Antispasmodics
- 52:24.00 — Mydriatics
- FDA label
- Download (164 KB)
- MSDS
- Download (73.5 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Basic Science Myopia 1 4 Completed Diagnostic Intraocular Pressure Changes During Tracheal Extubation 1 4 Completed Prevention Alzheimer's Disease (AD) / Delirium, Dementia, Amnestic, Cognitive Disorders / Mild Cognitive Impairment (MCI) 1 4 Completed Prevention Arrhythmia / Respiratory Arrest 1 4 Completed Prevention Bradycardia 1 4 Completed Prevention Bradycardia / Dexmedetomidine / Spinal Anaesthesia 1 4 Completed Prevention Intubation, Endotracheal 1 4 Completed Prevention Myopia 1 4 Completed Screening Anesthesia; Functional 1 4 Completed Supportive Care Nausea / Vomiting 1
Pharmacoeconomics
- Manufacturers
- Meridian medical technologies inc
- Solvay pharmaceuticals
- United states army office surgeon general
- Hospira inc
- Mission pharmacal co
- Packagers
- Advanced Pharmaceutical Services Inc.
- Akorn Inc.
- Alcon Laboratories
- American Regent
- Amphastar Pharmaceuticals
- APP Pharmaceuticals
- A-S Medication Solutions LLC
- Baroli
- Bausch & Lomb Inc.
- Baxter International Inc.
- Bioniche Pharma
- Cardinal Health
- Carlisle Laboratories Inc.
- Clipper Distributing Co. LLC
- Contract Pharm
- Dispensing Solutions
- E. Fougera and Co.
- Falcon Pharmaceuticals Ltd.
- General Injectables and Vaccines Inc.
- Hawthorn Pharmaceuticals
- Hope Pharmaceuticals
- Hospira Inc.
- Luitpold Pharmaceuticals Inc.
- Mallinckrodt Inc.
- Mckesson Corp.
- Meridian Medical Technologies Inc.
- MWI Veterinary Supply Co.
- Nycomed Inc.
- Ocumed Inc.
- OMJ Pharmaceuticals
- PD-Rx Pharmaceuticals Inc.
- Pharmedium
- Physicians Total Care Inc.
- Prometic Pharma Inc.
- Rx Veterinary Products
- Spectrum Pharmaceuticals
- Teva Pharmaceutical Industries Ltd.
- Vedco Inc.
- Wa Butler Co.
- Dosage Forms
Form Route Strength Solution / drops Ophthalmic Kit Intramuscular Injection Intramuscular 0.25 mg/0.3mL Solution Parenteral Solution Conjunctival; Ophthalmic 10 mg Injection, solution Intravenous Ointment Ophthalmic Solution Ophthalmic Solution Intravenous; Subcutaneous Solution Intravenous Solution Intramuscular; Subcutaneous Solution Intramuscular; Intravenous; Subcutaneous Solution Ophthalmic 1 % Solution / drops Ophthalmic 1 % Ointment Ophthalmic 1 % Injection Injection Intramuscular; Intravenous; Subcutaneous 0.4 mg/1mL Injection Intravenous 0.1 mg/1mL Injection Intravenous; Parenteral 0.1 mg/1mL Injection Parenteral 0.1 mg/1mL Injection, solution Endotracheal; Intramedullary; Intramuscular; Intravenous; Subcutaneous 0.4 mg/1mL Injection, solution Endotracheal; Intramuscular; Intravenous; Subcutaneous 0.05 mg/1mL Injection, solution Endotracheal; Intramuscular; Intravenous; Subcutaneous 0.1 mg/1mL Injection, solution Intramuscular 0.1 mg/1mL Injection, solution Intramuscular; Intravenous; Subcutaneous 0.1 mg/1mL Injection, solution Intramuscular; Intravenous; Subcutaneous 0.4 mg/1mL Injection, solution Intramuscular; Intravenous; Subcutaneous 0.4 mg/0.5mL Injection, solution Intramuscular; Intravenous; Subcutaneous 1 mg/1mL Injection, solution Intravenous 0.1 mg/1mL Injection, solution Intravenous 0.4 mg/1mL Injection, solution Intravenous 1 mg/1mL Ointment Ophthalmic 10 mg/1g Solution Ophthalmic 1 mg/1mL Solution Ophthalmic 10 mg/1mL Solution / drops Ophthalmic 10 mg/1mL Liquid Intravenous .1 mg Solution Intramuscular; Intravenous; Subcutaneous 0.3 mg Solution Intramuscular; Intravenous; Subcutaneous 0.8 mg Solution Intramuscular; Intravenous; Subcutaneous 0.4 mg Solution Intramuscular; Intravenous; Subcutaneous 0.6 mg Solution Intramuscular; Intravenous; Subcutaneous 1 mg Injection, solution Intramuscular; Intravenous; Subcutaneous Solution Intramuscular; Intravenous; Subcutaneous 0.5 mg Solution Intramuscular; Intravenous; Subcutaneous 3 mg Solution Intramuscular; Intravenous; Subcutaneous .6 mg Injection Parenteral Injection, solution Injection, solution Parenteral Solution / drops Ophthalmic 10 mg Capsule Oral Solution Oral Tablet, film coated, extended release Oral Injection, solution Intravenous Injection Intravenous Tablet Oral Injection Intramuscular 0.5 mg/0.7mL Injection Intramuscular 1 mg/0.7mL Injection Intramuscular 2 mg/0.7mL Solution / drops Ophthalmic Injection Intramuscular; Intravenous; Subcutaneous Liquid Ophthalmic 1 % Elixir Oral Tablet, extended release Oral Liquid Oral Tablet Solution Tablet Solution Suspension - Prices
Unit description Cost Unit Atropine Sulfate 1% Solution 15ml Bottle 101.27USD bottle Isopto Atropine 1% Solution 15ml Bottle 34.65USD bottle Atropine powder 34.48USD g Isopto Atropine 1% Solution 5ml Bottle 26.59USD bottle Atropine Sulfate 1% Solution 5ml Bottle 16.82USD bottle Atropine Sulfate 1% Ointment 3.5 gm Tube 15.92USD tube Atropine-Care 1% Solution 2ml Bottle 7.99USD bottle Isopto atropine 1% eye drops 5.06USD ml Atropine-ns 1 mg/2.5 ml syr 4.8USD ml Atropine-ns 0.8 mg/2 ml syr 3.9USD ml Atropine 1% eye drops 2.88USD ml Atropine sulfate powder 2.06USD g Atropine care 1% eye drops 2.03USD ml Atropine-ns 2 mg/5 ml syringe 1.92USD ml Atropine Sulfate 0.4 mg/ml 1.6USD ml Atropine Sulfate 0.6 mg/ml 1.6USD ml Atropine 1 mg/ml vial 1.44USD ml Atropine Sulfate 0.4 mg/ml Solution 1.22USD ml Atropine 0.4 mg/0.5 ml ampul 1.2USD ampul Atropine 1 mg/ml ampul 1.2USD ml Atropine 0.4 mg/ml vial 0.96USD ml Isopto Atropine 1 % Solution 0.68USD ml Sal-tropine 0.4 mg tablet 0.36USD tablet DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 118.5 °C PhysProp water solubility 2200 mg/L (at 25 °C) DEHN,WM (1917) logP 1.83 HANSCH,C ET AL. (1995) logS -2.12 ADME Research, USCD pKa 9.43 SANGSTER (1994) - Predicted Properties
Property Value Source Water Solubility 2.52 mg/mL ALOGPS logP 2.19 ALOGPS logP 1.57 ChemAxon logS -2.1 ALOGPS pKa (Strongest Acidic) 15.15 ChemAxon pKa (Strongest Basic) 9.39 ChemAxon Physiological Charge 1 ChemAxon Hydrogen Acceptor Count 3 ChemAxon Hydrogen Donor Count 1 ChemAxon Polar Surface Area 49.77 Å2 ChemAxon Rotatable Bond Count 5 ChemAxon Refractivity 80.82 m3·mol-1 ChemAxon Polarizability 31.28 Å3 ChemAxon Number of Rings 3 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9286 Blood Brain Barrier + 0.9569 Caco-2 permeable + 0.8866 P-glycoprotein substrate Substrate 0.5 P-glycoprotein inhibitor I Non-inhibitor 0.6542 P-glycoprotein inhibitor II Non-inhibitor 0.8595 Renal organic cation transporter Inhibitor 0.7956 CYP450 2C9 substrate Non-substrate 0.7041 CYP450 2D6 substrate Non-substrate 0.6838 CYP450 3A4 substrate Substrate 0.5496 CYP450 1A2 substrate Non-inhibitor 0.9045 CYP450 2C9 inhibitor Non-inhibitor 0.9275 CYP450 2D6 inhibitor Non-inhibitor 0.9231 CYP450 2C19 inhibitor Non-inhibitor 0.9285 CYP450 3A4 inhibitor Non-inhibitor 0.95 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9113 Ames test Non AMES toxic 0.7742 Carcinogenicity Non-carcinogens 0.9631 Biodegradation Ready biodegradable 0.5527 Rat acute toxicity 2.7305 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.8354 hERG inhibition (predictor II) Inhibitor 0.5378
Spectra
- Mass Spec (NIST)
- Download (7.92 KB)
- Spectra
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Antagonist
- General Function
- Phosphatidylinositol phospholipase c activity
- Specific Function
- The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the...
- Gene Name
- CHRM1
- Uniprot ID
- P11229
- Uniprot Name
- Muscarinic acetylcholine receptor M1
- Molecular Weight
- 51420.375 Da
References
- Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. [PubMed:7855217]
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Antagonist
- General Function
- G-protein coupled acetylcholine receptor activity
- Specific Function
- The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the...
- Gene Name
- CHRM2
- Uniprot ID
- P08172
- Uniprot Name
- Muscarinic acetylcholine receptor M2
- Molecular Weight
- 51714.605 Da
References
- Roman S, Badia A, Camps P, Munoz-Torrero D, Clos MV: Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors. Brain Res. 2005 Nov 9;1061(2):73-9. Epub 2005 Oct 24. [PubMed:16248990]
- Minaba M, Ichiyama S, Kojima K, Ozaki M, Kato Y: Activation of nematode G protein GOA-1 by the human muscarinic acetylcholine receptor M2 subtype. Functional coupling of G-protein-coupled receptor and G protein originated from evolutionarily distant animals. FEBS J. 2006 Dec;273(24):5508-16. Epub 2006 Nov 3. [PubMed:17087737]
- May LT, Lin Y, Sexton PM, Christopoulos A: Regulation of M2 muscarinic acetylcholine receptor expression and signaling by prolonged exposure to allosteric modulators. J Pharmacol Exp Ther. 2005 Jan;312(1):382-90. Epub 2004 Aug 27. [PubMed:15333678]
- Cembala TM, Forde SC, Appadu BL, Lambert DG: Allosteric interaction of the neuromuscular blockers vecuronium and pancuronium with recombinant human muscarinic M2 receptors. Eur J Pharmacol. 2007 Aug 13;569(1-2):37-40. Epub 2007 May 22. [PubMed:17588565]
- Nelson CP, Nahorski SR, Challiss RA: Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor. J Pharmacol Exp Ther. 2006 Jan;316(1):279-88. Epub 2005 Sep 27. [PubMed:16188951]
- Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. [PubMed:7855217]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Antagonist
- General Function
- Receptor activity
- Specific Function
- The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the...
- Gene Name
- CHRM3
- Uniprot ID
- P20309
- Uniprot Name
- Muscarinic acetylcholine receptor M3
- Molecular Weight
- 66127.445 Da
References
- Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. [PubMed:7855217]
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Antagonist
- General Function
- Guanyl-nucleotide exchange factor activity
- Specific Function
- The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the...
- Gene Name
- CHRM4
- Uniprot ID
- P08173
- Uniprot Name
- Muscarinic acetylcholine receptor M4
- Molecular Weight
- 53048.65 Da
References
- Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. [PubMed:7855217]
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Antagonist
- General Function
- Phosphatidylinositol phospholipase c activity
- Specific Function
- The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the...
- Gene Name
- CHRM5
- Uniprot ID
- P08912
- Uniprot Name
- Muscarinic acetylcholine receptor M5
- Molecular Weight
- 60073.205 Da
References
- Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. [PubMed:7855217]
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Antagonist
- General Function
- Transmitter-gated ion channel activity
- Specific Function
- The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
- Gene Name
- GLRA1
- Uniprot ID
- P23415
- Uniprot Name
- Glycine receptor subunit alpha-1
- Molecular Weight
- 52623.35 Da
References
- Jensen AA, Kristiansen U: Functional characterisation of the human alpha1 glycine receptor in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2004 May 1;67(9):1789-99. [PubMed:15081878]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Ligand-gated ion channel activity
- Specific Function
- After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeabl...
- Gene Name
- CHRNA4
- Uniprot ID
- P43681
- Uniprot Name
- Neuronal acetylcholine receptor subunit alpha-4
- Molecular Weight
- 69956.47 Da
References
- Smulders CJ, Zwart R, Bermudez I, van Kleef RG, Groot-Kormelink PJ, Vijverberg HP: Cholinergic drugs potentiate human nicotinic alpha4beta2 acetylcholine receptors by a competitive mechanism. Eur J Pharmacol. 2005 Feb 21;509(2-3):97-108. [PubMed:15733544]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Ligand-gated ion channel activity
- Specific Function
- After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeabl...
- Gene Name
- CHRNB2
- Uniprot ID
- P17787
- Uniprot Name
- Neuronal acetylcholine receptor subunit beta-2
- Molecular Weight
- 57018.575 Da
References
- Smulders CJ, Zwart R, Bermudez I, van Kleef RG, Groot-Kormelink PJ, Vijverberg HP: Cholinergic drugs potentiate human nicotinic alpha4beta2 acetylcholine receptors by a competitive mechanism. Eur J Pharmacol. 2005 Feb 21;509(2-3):97-108. [PubMed:15733544]
Transporters
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- Transporter activity
- Specific Function
- Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
- Gene Name
- ABCB11
- Uniprot ID
- O95342
- Uniprot Name
- Bile salt export pump
- Molecular Weight
- 146405.83 Da
References
- Pedersen JM, Matsson P, Bergstrom CA, Hoogstraate J, Noren A, LeCluyse EL, Artursson P: Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43. doi: 10.1093/toxsci/kft197. Epub 2013 Sep 6. [PubMed:24014644]
Drug created on June 13, 2005 13:24 / Updated on April 12, 2021 12:00