Advanced Colorectal Cancer (DBCOND0034287)

Identifiers

Synonyms
Advanced Colorectal Neoplasm / Advanced Colorectal Neoplasms

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Leucovorin
A folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer.
Levoleucovorin
A folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer.
Oxaliplatin
A platinum based chemotherapy agent used to treat carcinoma of the colon or rectum or stage III colon cancer.
Raltitrexed
A folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05255588
A Stool DNA-based SDC2 Methylation Test for the Early Detection of Colorectal CancerNo drug interventionsNot AvailableNot Availablerecruiting
NCT01341197
Fecal Screening Assay for Taiwanese PopulationNo drug interventionsNot AvailableNot Availablecompleted
NCT01929421
A Phase II Trial of Salvage Treatment With Gemcitabine and S-1 Combination in Patients With Heavily Treated Advanced Colorectal Cancer.treatment2completed
NCT00853684
Oxaliplatin, Capecitabine and Endostar as First Line Treatment for Patients With Advanced Colorectal Cancertreatment2unknown_status
NCT05963087
Cetuximab in Combination With Dabrafenib and Tislelizumab in BRAF Mutated Treatment of Advanced Colorectal CancertreatmentNot Availablenot_yet_recruiting
NCT05028933
IMC001 for Clinical Research on Advanced Digestive System MalignanciesNo drug interventionstreatment1recruiting
NCT00598247
A Pilot Study of PPX in Women With Metastatic Colorectal Cancertreatment1completed
NCT00386828
Chemoradiation for Locally Advanced and Low Rectal Cancers: Avastin-Capecitabine-Oxaliplatin-Radiation REctal Cancer Trialtreatment2completed
NCT03699111
Identification of New Patient Stratification Tools in MSS RAS mt mCRCNo drug interventionsNot AvailableNot Availablecompleted
NCT06585488
A First-in-human Study of BGB-53038, a Pan-KRAS Inhibitor, Alone or in Combinations in Participants with Advanced or Metastatic Solid Tumors with KRAS Mutations or AmplificationNo drug interventionstreatment1not_yet_recruiting
NCT00498407
A Phase II Study of CP-4055 as Second Line Therapy in Patients With Advanced Colorectal Cancertreatment2completed
NCT02826837
LEAC-102 for Advanced Colorectal Cancertreatment1 / 2unknown_status
NCT00286000
High Dose Simplified Folfiri in Advanced Colorectal Cancer: a Multicentre Phase II Studytreatment2completed
NCT06369259
Open-label Phase 2 Study of Avutometinib (RAF/MEK Clamp) in Combination With Defactinib (FAK Inhibitor) and Cetuximab in Patients With Unresectable, Anti-EGFR-Refractory Advanced Colorectal Cancertreatment2not_yet_recruiting
NCT04793958
Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)treatment3active_not_recruiting
NCT05077839
Trifluridine/Tipiracil Combined With Oxaliplatin and Bevacizumab Versus XELOX Plus Bevacizumab in mCRCtreatment2recruiting
NCT02138422
A Phase 3 Study to Evaluate Xilonix as an Anticancer Therapy in Patients With Symptomatic Colorectal CancerNo drug interventionstreatment3completed
NCT06199973
Injection of SHR-A1811 Versus Physician Choiced Treatment in Patients With Advanced Colorectal Cancer Who Had Failed to Respond to Oxaliplatin, 5-fu, and Irinotecantreatment3recruiting
NCT00637091
Efficacy Analysis of Cetuximab Plus Irinotecan in Patients With Wild-type KRAS Without Regard to Epidermal Growth Factor Receptor (EGFR) Expressionstreatment2completed
NCT00707889
Phase 2 Study of ABT-869 in Combination With mFOLFOX6 Versus Bevacizumab in Combination With mFOLFOX6 to Treat Advanced Colorectal Cancertreatment2completed
NCT05364489
Efficacy, Safety and Exploratory Clinical Study of Bevacizumab Combined With Oxaliplatin and TAS-102 in First-line Treatment of Advanced Colorectal Cancertreatment2not_yet_recruiting
NCT03427268
Clinical Trial of PM60184 in Advanced Colorectal Cancer After Standard Treatmenttreatment2completed
NCT01723969
Screening Platform for Clinical Trials in Advanced Colorectal CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT06446050
Chemokine and Co-stimulatory Molecule-modified Mesenchymal Stem Cells for the Treatment of Advanced Colorectal CancerNo drug interventionstreatment0recruiting
NCT00309179
A Phase II Study of the Safety and Efficacy of E7820 Plus Cetuximab in Colorectal Cancer, Preceded by a Run-in Study in Advanced Solid Tumorstreatment2completed
NCT04337879
A Study of AL2846 Capsule Combined With Standard Chemotherapy Regimen in Subjects With Advanced Colorectal Cancertreatment1 / 2unknown_status
NCT00824161
Phase II Study of TAS-109 to Treat Advanced Colorectal Cancertreatment2terminated
NCT03126071
Raltitrexed-based Chemotherapy Plus Bevacizumab in Retreated Patients With Advanced Colorectal Cancertreatment2unknown_status
NCT00854971
Efficacy Study of TKcell in Advanced Colorectal Cancertreatment1 / 2unknown_status
NCT04252456
Folfiri/aflIbercept in Metastatic coloreCTal Cancer patIents With RAS Validated Wild typE StatusNo drug interventionstreatmentNot Availableunknown_status
NCT04929652
Surufatinib Combine With Immunotherapy and Chemotherapy for Second-line Treatment in Advanced Colorectal Cancertreatment1 / 2unknown_status
NCT00312000
Sequential Versus Combination Chemotherapy in Advanced Colorectal Carcinomatreatment3completed
NCT02038699
A First-in-man Phase I/II Study of Oral ONC201 in Patients With Advanced Cancertreatment1 / 2withdrawn
NCT04764006
Surufatinib Combined With Sintilimab for Advanced MSS-Type Colorectal Cancer : a Phase II Studytreatment2unknown_status
NCT04734249
Second-line Surufatinib Combined With Chemotherapy in Advanced CRCtreatment2unknown_status
NCT05731336
A Prospective Cohort Study of Advanced Colorectal Cancer Treated With Oxaliplatin and Irinotecan.No drug interventionsNot AvailableNot Availablerecruiting
NCT04835324
Regorafenib Treatment Patterns and Survival Outcomes in Advanced Colorectal Cancer: A Real-world StudyNo drug interventionsNot AvailableNot Availableunknown_status
NCT00952016
Methotrexate in Metastatic Colorectal Cancer With MSH2 Deficiencytreatment2terminated
NCT01859858
Effect of Curcumin on Dose Limiting Toxicity and Pharmacokinetics of Irinotecan in Patients With Solid Tumorsbasic_science1completed
NCT02619435
Regorafenib Monotherapy as Second-line Treatment of Patients With RAS-mutant Advanced Colorectal Cancertreatment2active_not_recruiting
NCT06200363
A Clinical Study of T3011 in Combination With Regorafenib in Patients With Advanced Colorectal Cancertreatment1recruiting
NCT02923622
Efficacy and Safety Evaluation of Traditional Chinese Medicine in the Treatment of Advanced Colorectal CancerNo drug interventionsNot AvailableNot Availableunknown_status
NCT01271166
GlivecĀ® Plus m-FOLFOX AvastinĀ® in Advanced Colorectal Cancertreatment1terminated
NCT00972465
Study of Nimotuzumab to Treat Colorectal Cancertreatment2unknown_status
NCT03524274
Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Colorectal CancerNo drug interventionstreatment2withdrawn
NCT04744831
Trastuzumab Deruxtecan in Participants With HER2-overexpressing Advanced or Metastatic Colorectal Cancertreatment2active_not_recruiting
NCT04324476
A Study of Bevacizumab Plus XELOX/XELIRI for First-line Treatment in Unresectable Advanced Colorectal Cancertreatment2unknown_status
NCT01822444
ANGIOPREDICT. ICORG 12-16, V3No drug interventionsNot AvailableNot Availablecompleted
NCT02227667
Evaluate the Efficacy of MEDI4736 in Immunological Subsets of Advanced Colorectal Cancertreatment2completed
NCT05495672
Circulating Tumor DNA Guided Therapeutic Strategies for CRC Patients With Small Pulmonary NodulesNo drug interventionstreatmentNot Availablerecruiting
NCT05424068
Rehabilitation for People With Advanced CancerNo drug interventionssupportive_careNot Availablerecruiting
NCT00959946
Study Of Bosutinib With Capecitabine In Solid Tumors And Locally Advanced Or Metastatic Breast Cancertreatment1 / 2terminated
NCT05928312
Fruquintinib Combined With Chemotherapy as Third-line /Third-line+ Treatment in Advanced Colorectal CancertreatmentNot Availablenot_yet_recruiting
NCT05194995
JAB-21822 in Combination With Cetuximab in Patients With Advanced CRC and Other Solid Tumors With KRAS G12C Mutationtreatment1 / 2active_not_recruiting
NCT05035914
Anlotinib Combined With mXELIRI as Second-line Treatment of Advanced Colorectal Cancertreatment1 / 2recruiting
NCT03311750
Anti-EGFR Therapy Rechallenge in Combination With Chemotherapy in Patients With Advanced Colorectal Cancertreatment2terminated