Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer. Raltitrexed (brand name Tomudex®) is a chemotherapy drug manufactured AstraZeneca Company, is an antimetabolite used in chemotherapy.
- Mechanism
- Curator reviewed
Raltitrexed is an antineoplastic Agents and folic acid antagonists. Raltitrexed inhibits thymidylate synthase (TS) leading to DNA fragmentation and cell death. It is transported into cells via a reduced folate carrier. Inside the cell Raltitrexed is extensively polyglutamated, which enhances thymidylate synthase inhibitory power and duration. Inhibition of this enzyme results in decreased synthesis of thymidine triphosphate which is required for DNA synthesis.
- Primary indication
- For the treatment of malignant neoplasm of colon and rectumCurator reviewed · 2 structured indications
- Formula / weight
- C21H22N4O6S · 458.488 g/mol (avg)
- First approval
- Canada, 2021
- Code names
- ZD-1694
- Brand names
Resolves to
IVTVGDXNLFLDRM-HNNXBMFYSA-NSMILESCN(CC1=CC2=C(NC(C)=NC2=O)C=C1)C1=CC=C(S1)C(=O)N[C@@H](CCC(O)=O)C(O)=OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Raltitrexed, and which of those have an active Phase 3 trial?
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