Complicated Skin and Skin Structure Infection (DBCOND0034356)

Identifiers

Synonyms

Complicated Skin and Skin Structure Infections (cSSSI) / Complicated Skin and skin structure infections / Complicated skin and skin structure infection / Bacterial infection of skin (disorder) / Skin Diseases, Bacterial / Skin bacterial infection

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Daptomycin	A cyclic lipopeptide antibiotic used to treat complicated skin and skin structure infections by susceptible Gram-positive bacteria and bacteremia due to Staphylococcus aureus.	Cytoplasmic membranetarget Albumincarrier Alpha-1-acid glycoprotein 1carrier Alpha-1-antitrypsincarrier Low-density lipoprotein receptorcarrier Sex hormone-binding globulincarrier Hemopexincarrier ATP-dependent translocase ABCB1transporter Dihydropteroate synthasetarget
Tigecycline	A glycylcycline antibiotic used to treat a number of susceptible bacterial infections.	30S ribosomal protein S9target 16S ribosomal RNAtarget 30S ribosomal protein S14target 30S ribosomal protein S13target 30S ribosomal protein S19target 30S ribosomal protein S12target
Trovafloxacin	An antibiotic used to treat gonorrhea and chlamydia.	DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 2-alphatarget Cytochrome P450 1A2enzyme DNA gyrase subunit Atarget DNA gyrase subunit Btarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01293435	Study Evaluating Management of Patients With Community-Acquired Pneumonia (CAP) or Complicated Skin Infections	No drug interventions	Not Available	Not Available	completed
NCT01175707	Study Comparing Cubicin With Vancomycin in Treatment of Participants With Complicated Skin and Skin Structure Infections in a Home Infusion Setting	Daptomycin Vancomycin	health_services_research	4	terminated
NCT01072539	Study Evaluating The Safety And Effectiveness In Subjects With Tigecycline Treatment	Tigecycline	Not Available	Not Available	completed
NCT01104662	Study of Daptomycin Safety and Efficacy for Complicated Skin and Skin Structure Infections (cSSSI) and Bacteremia in Renal Impairment	Benzylpenicillin Cloxacillin Daptomycin Nafcillin Oxacillin Vancomycin	treatment	4	terminated
NCT01363271	Cost Study of Linezolid Versus Vancomycin Among Previously Hospitalized Patients	Linezolid Vancomycin	Not Available	Not Available	completed
NCT00683332	Post-Marketing Study Of The Safety Of Tygacil (Tigecycline)	Tigecycline	Not Available	Not Available	completed
NCT02288234	Telavancin Observational Use Registry (TOUR)	Telavancin	Not Available	Not Available	completed
NCT01128530	Efficacy and Safety Study of JNJ-32729463 for Treating Complicated Skin and Skin Structure Infections Compared to Linezolid (Zyvox)	Linezolid	treatment	2	completed
NCT00299520	Phase 3 Safety and Efficacy Study of I.V. Iclaprim v Linezolid in cSSSI (ASSIST-1)	Iclaprim Linezolid	treatment	3	completed