Trovafloxacin is an antibiotic used to treat gonorrhea and chlamydia. Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer.
- Mechanism
- Curator reviewed
Trovafloxacin is a fluoronaphthyridone related to the fluoroquinolones with in vitro activity against a wide range of gram-negative and gram-positive aerobic and anaerobic microorganisms. The bactericidal action of trovafloxacin results from inhibition of DNA gyrase and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription, and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division.
- Primary indication
- For treatment of infections caused by susceptible strains of the designated microorganisms in uncomplicated urethral gonorrhea in males and endocervical and rectal gonorrhea in females caused by Neisseria gonorrhoeae as well as non gonoccocal urethritis...Curator reviewed · 5 structured indications
- Formula / weight
- C20H15F3N4O3 · 416.36 g/mol (avg)
- First approval
- Canada, 1998 · United States, 2006
- Code names
- CP-99219
- Brand names
Resolves to
WVPSKSLAZQPAKQ-CDMJZVDBSA-NSMILES[H][C@@]12CN(C[C@]1([H])[C@H]2N)C1=NC2=C(C=C1F)C(=O)C(=CN2C1=C(F)C=C(F)C=C1)C(O)=OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Trovafloxacin, and which of those have an active Phase 3 trial?
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