Exercise-Induced Bronchospasm (DBCOND0035673)

Identifiers

Synonyms

Bronchospasm, Exercise-Induced / Exercise-Induced Bronchoconstriction / Exercise Induced Bronchospasm / Exercise Induced Bronchoconstriction / Exercise-induced bronchospasm / Exercise induced bronchospasm (disorder) / Spasm bronchial / Bronchial Spasm / Bronchospasm (finding) / Bronchospasm / Bronchospasm NOS

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Albuterol	A beta-2 adrenergic receptor agonist used to treat asthma, bronchitis, COPD, as well as prevent exercise induced bronchospasms.	Beta-2 adrenergic receptortarget Beta-1 adrenergic receptortarget Cytochrome P450 3A4enzyme Beta-3 adrenergic receptortarget
Cromoglicic acid	A medication used to treat asthma, allergic reactions of the eyes and nose, as well as other mast cell reactions.	Protein S100-Ptarget Heat shock protein HSP 90-alphatarget
Formoterol	An inhaled long-acting beta2-adrenergic receptor agonist used as a bronchodilator in the management of asthma and COPD.	Beta-2 adrenergic receptortarget Beta-1 adrenergic receptortarget Beta-3 adrenergic receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2A6enzyme UDP-glucuronosyltransferase 1A8enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 2B15enzyme Solute carrier family 22 member 1transporter Solute carrier family 22 member 4transporter Organic cation/carnitine transporter 2transporter Solute carrier family 22 member 3transporter Albumincarrier UDP-glucuronosyltransferase 1A1enzyme
Montelukast	A leukotriene receptor antagonist used as part of an asthma therapy regimen, to prevent exercise induced bronchoconstriction, and to treat seasonal allergic rhinitis.	Cysteinyl leukotriene receptor 1target Polyunsaturated fatty acid 5-lipoxygenasetarget Cytochrome P450 3A4enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C8enzyme Solute carrier organic anion transporter family member 2B1transporter Prostaglandin G/H synthase 1enzyme Cytochrome P450 2A6enzyme
Salmeterol	A long-acting beta-2 adrenergic receptor agonist used to treat asthma and COPD.	Beta-2 adrenergic receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Beta-1 adrenergic receptortarget Beta-3 adrenergic receptortarget Albumincarrier alpha1-acid glycoproteincarrier Solute carrier family 22 member 1transporter Solute carrier family 22 member 2transporter Solute carrier family 22 member 3transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01691079	Effectiveness of Ipratropium Bromide in Preventing Exercise-induced Bronchoconstriction in Athletes	Ipratropium	treatment	4	completed
NCT05162703	Evaluation of Exercise Induced Bronchoconstriction Using a Novel Automated Digital Clinical Decision System	No drug interventions	diagnostic	Not Available	unknown_status
NCT04234464	A Study to Assess the Efficacy of Budesonide/Albuterol Metered-dose Inhaler (BDA MDI/PT027) on Exercise-induced Bronchoconstriction in Adults and Adolescents With Asthma	Albuterol Budesonide Eucalyptus oil Peppermint Xylitol	treatment	3	completed
NCT03063424	Hyperventilation Versus Exercise Testing Sensitivity in Exercise Induced Asthma	No drug interventions	diagnostic	Not Available	unknown_status
NCT00701025	Mechanisms of Exercise-induced Bronchospasm	No drug interventions	Not Available	Not Available	completed
NCT06336681	Inspiratory Muscle Training on The Severity of Exercise-Induced Bronchoconstriction and Time-Trial Performance (IMT_EIB)	No drug interventions	treatment	2	recruiting
NCT03587675	Diagnosis of EIB in Young Elite Athletes (13-18 y)	No drug interventions	diagnostic	Not Available	unknown_status
NCT00273689	Exercise Induced Bronchospasm in Children	Albuterol L-Acetylleucine Montelukast	prevention	4	completed
NCT00268723	Efficacy Study of Single-Dose Levalbuterol Tartrate HFA MDI Vs Placebo in Subjects 18 Years and Older With EIB	Levosalbutamol	treatment	3	completed
NCT06480084	Prevalence of EILO Among Children With Asthma	No drug interventions	diagnostic	Not Available	not_yet_recruiting
NCT00662779	Bronchoprotective Effect of Arformoterol in Children With Exercise-Induced Bronchospasm (EIB)	Arformoterol Formoterol L-Acetylleucine	prevention	3	withdrawn
NCT00375232	Effects of Montelukast on Occult Exercise-Induced Bronchospasm in Athletes	No drug interventions	prevention	Not Available	withdrawn
NCT03610932	Vitamin C & Exercise Induced Bronchoconstriction (EIB)	No drug interventions	basic_science	Not Available	withdrawn
NCT05105529	Adaptation to Ozone in Individuals With Asthma/Exercise-induced Bronchoconstriction	No drug interventions	basic_science	Not Available	unknown_status
NCT03586544	Reducing Exercise-induced Bronchoconstriction in Children With Asthma and Obesity	Albuterol	prevention	4	terminated
NCT03505216	Swiss Paediatric Airway Cohort	No drug interventions	Not Available	Not Available	recruiting
NCT00085774	Comparison of Two Bronchodilator Inhalers in Adolescents and Adults With Exercise-Induced Asthma	Albuterol	treatment	3	completed
NCT04408664	Influence of Cromones on Eucapnic Hyperventilation (EVH)-Test in Young (Elite) Athletes Who Tested Positive for EIB.	Cromoglicic acid Sodium chloride	treatment	3	terminated
NCT02252302	Exercise in Air Pollution and Lung Health in Asthmatics	Albuterol	basic_science	Not Available	completed
NCT01504646	Effect of a Component of Fish Oil on Exercise-Induced Bronchoconstriction and Airway Inflammation in Asthma	No drug interventions	basic_science	Not Available	completed
NCT01791972	Efficacy of Albuterol SPIROMAX® in Adult and Adolescent Patients With Exercise-Induced Bronchoconstriction (EIB)	Albuterol	treatment	3	completed
NCT00534976	The Effect of Montelukast on Difficulty in Breathing After Exercise in Pediatric Patients (MK0476-377)(COMPLETED)	Montelukast	treatment	4	completed
NCT01214551	Exercise-induced Bronchoconstriction Diagnostics: Impact of a Repeated Exercise Challenge Test	No drug interventions	Not Available	Not Available	completed
NCT04103632	Screening and Diagnosing Exercise-induced Bronchoconstriction in Recreational Young Athletes (12-18 y)	No drug interventions	screening	Not Available	completed
NCT04275648	Exercise Induced Bronchoconstriction and Field Tests	No drug interventions	diagnostic	Not Available	unknown_status