Refractory Mantle Cell Lymphoma (DBCOND0041116)

Identifiers

Synonyms
Refractory Mantle Cell Lymphoma (MCL) / Mantle Cell Lymphoma Refractory

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Bendamustine
An antineoplastic nitrogen mustard agent used in the treatment of indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed following rituximab therapy.
Brexucabtagene autoleucel
A modified autologous chimeric antigen receptor (CAR) T cell therapy employing a modified murine anti-CD19 single-chain variable fragment linked to CD28 and CD3ζ co-stimulatory domains for the treatment of patients with relapsed and refractory mantle cell lymphoma.
Ibrutinib
An antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia.
Lisocabtagene maraleucel
A CAR T-cell therapy for treatment resistant or more severe B-cell lymphomas.
Pirtobrutinib
A kinase inhibitor used to treat relapsed or refractory mantle cell lymphoma (MCL) after at least two lines of systemic therapy.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05471843
Study of BGB-11417 Monotherapy in Participants With Relapsed or Refractory Mantle Cell LymphomaNo drug interventionstreatment1 / 2recruiting
NCT05645744
Long-term Follow-up Study in Patients Previously Treated With a Mustang Bio CAR-T Cell Investigational Product.No drug interventionsNot AvailableNot Availableterminated
NCT05360238
Study to Assess Safety, Tolerability and Efficacy of MB-106 in Patients With Relapsed or Refractory B-Cell NHL or CLLNo drug interventionstreatment1 / 2terminated
NCT05864742
Genetically Risk-Stratified Venetoclax, Ibrutinib, Rituximab (± Navitoclax) in Relapsed/Refractory Mantle Cell LymphomaNo drug interventionstreatment2active_not_recruiting
NCT05833763
A Phase 2 Trial of GlOfitamab anD pIrtobrutinib in Mantle Cell Lymphoma Patients With Prior BTK Inhibitor Exposure.No drug interventionstreatment2recruiting
NCT01389427
Escalating Doses of Torisel in Combination With Three Chemotherapies Regimens: R-CHOP, R-FC or R-DHA for Patients With Relapsed/Refractory Mantle Cell Lymphoma (MCL).No drug interventionstreatment1 / 2completed
NCT01921387
Radiolabeled Monoclonal Antibody and Combination Chemotherapy Before Stem Cell Transplant in Treating Patients With High-Risk Lymphoid Malignanciestreatment1 / 2completed
NCT02568553
Lenalidomide and Blinatumomab for the Treatment of Relapsed Non-Hodgkin Lymphomatreatment1active_not_recruiting
NCT04635683
Lenalidomide, Umbralisib, and Ublituximab for the Treatment of Relapsed or Refractory Indolent Non-Hodgkin Lymphoma or Mantle Cell Lymphomatreatment1withdrawn
NCT06300528
Pemigatinib for the Treatment of Patients With Relapsed or Refractory Mantle Cell Lymphoma or Marginal Zone Lymphomatreatment2not_yet_recruiting
NCT03579888
CD19-Specific T Cells Post AlloSCTtreatment1terminated
NCT04205409
Nivolumab for Relapsed, Refractory, or Detectable Disease Post Chimeric Antigen Receptor T-cell Treatment in Patients With Hematologic Malignanciestreatment2active_not_recruiting
NCT04578600
CC-486, Lenalidomide, and Obinutuzumab for the Treatment of Recurrent or Refractory CD20 Positive B-cell Lymphomatreatment1active_not_recruiting
NCT05025800
ALX148, Rituximab and Lenalidomide for the Treatment of Indolent and Aggressive B-cell Non-Hodgkin Lymphomatreatment1 / 2recruiting
NCT05249959
Consolidation With Loncastuximab Tesirine After a Short Course of Immunochemotherapy in BTKi-treated (or Intolerant) Relapsed/Refractory Mantle Cell Lymphoma Patients.treatment2recruiting
NCT03206970
Study to Evaluate Efficacy and Safety of BGB-3111 in Participants With Relapsed or Refractory Mantle Cell Lymphoma (MCL)treatment2completed
NCT01955499
Lenalidomide and Ibrutinib in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphomatreatment1active_not_recruiting
NCT00723099
Donor Umbilical Cord Blood Transplant in Treating Patients With Hematologic CancerNo drug interventionstreatment2completed
NCT04995536
CpG-STAT3 siRNA CAS3/SS3 and Localized Radiation Therapy for the Treatment of Relapsed/Refractory B-Cell NHLNo drug interventionstreatment1withdrawn
NCT02736617
Obinutuzumab in Combination With Ibrutinib in Treating Patients With Relapsed Mantle Cell Lymphomatreatment2completed
NCT05453396
Loncastuximab Tesirine for the Treatment of Relapsed or Refractory B-Cell Malignanciestreatment2recruiting
NCT02051257
Memory Enriched T Cells Following Stem Cell Transplant in Treating Patients With Recurrent B-Cell Non-Hodgkin LymphomaNo drug interventionstreatment1active_not_recruiting
NCT04007029
Modified Immune Cells (CD19/CD20 CAR-T Cells) in Treating Patients With Recurrent or Refractory B-Cell Lymphoma or Chronic Lymphocytic Leukemiatreatment1recruiting
NCT01381692
Bortezomib, Rituximab, and Dexamethasone With or Without Temsirolimus in Treating Patients With Untreated or Relapsed Waldenstrom Macroglobulinemia or Relapsed or Refractory Mantle Cell or Follicular LymphomaNo drug interventionstreatment1 / 2completed
NCT04659044
Polatuzumab Vedotin, Venetoclax, and Rituximab and Hyaluronidase Human for the Treatment of Relapsed or Refractory Mantle Cell LymphomaNo drug interventionstreatment2active_not_recruiting
NCT01880567
Ibrutinib and Rituximab in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma or Older Patients With Newly Diagnosed Mantle Cell LymphomaNo drug interventionstreatment2active_not_recruiting
NCT05910801
Tafasitamab, Lenalidomide and Venetoclax for the Treatment of Relapsed or Refractory Mantle Cell LymphomaNo drug interventionstreatment2recruiting
NCT04484012
Modified Immune Cells (CD19 CAR T Cells) and Acalabrutinib for the Treatment of Relapsed or Refractory Mantle Cell LymphomaNo drug interventionstreatment2recruiting
NCT02420795
Akt/ERK Inhibitor ONC201 in Treating Patients With Relapsed or Refractory Non-Hodgkin's LymphomaNo drug interventionstreatment1 / 2terminated
NCT01719250
Buparlisib in Treating Patients With Relapsed or Refractory Non-Hodgkin LymphomaNo drug interventionstreatment0completed
NCT06191887
B-Cell Activating Factor Receptor (BAFFR)-Based Chimeric Antigen Receptor T-Cells With Fludarabine and Cyclophosphamide Lymphodepletion for the Treatment of Relapsed or Refractory B-cell Hematologic MalignanciesNo drug interventionstreatment1recruiting
NCT02869633
Ibrutinib in Treating Patients With Refractory or Relapsed Lymphoma After Donor Stem Cell TransplantNo drug interventionstreatment2completed
NCT02572453
Phase 2 Study of AT13387 (Onalespib) in ALK+ ALCL, MCL, and BCL-6+ DLBCLNo drug interventionstreatment2terminated
NCT03219047
Patient-Derived Xenografts in Personalizing Treatment for Patients With Relapsed/Refractory Mantle Cell LymphomaNo drug interventionstreatment0completed
NCT04047797
Ixazomib and Rituximab in Treating Patients With Relapsed or Refractory Mantle Cell LymphomaNo drug interventionstreatment2active_not_recruiting
NCT03946878
Venetoclax and Acalabrutinib in Treating Patients With Relapsed or Refractory Mantle Cell LymphomaNo drug interventionstreatment2active_not_recruiting
NCT04990778
Venetoclax and Eprenetapopt for the Treatment of Relapsed of Refractory Mantle Cell LymphomaNo drug interventionstreatment2withdrawn
NCT03061188
Phase I/Ib Study of Nivolumab & Veliparib in Patients With Advanced Solid Tumors & LymphomaNo drug interventionstreatment1completed
NCT03147885
Selinexor Plus Combination Chemotherapy in Treating Patients With Advanced B Cell Non-Hodgkin LymphomaNo drug interventionstreatment1 / 2recruiting
NCT04872413
Interrogating Biological Signaling Pathway Dysregulations and In Vitro Screening With Personalized Therapies in Relapsed or Refractory Mantle Cell Lymphoma, MCL MATCH TrialNo drug interventionsscreeningNot Availablerecruiting
NCT01695941
Alisertib, Bortezomib, and Rituximab in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma or B-cell Low Grade Non-Hodgkin LymphomaNo drug interventionstreatment1active_not_recruiting
NCT01865617
Laboratory Treated T Cells in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Non-Hodgkin Lymphoma, or Acute Lymphoblastic LeukemiaNo drug interventionstreatment1 / 2completed
NCT03015896
Nivolumab and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin LymphomaNo drug interventionstreatment1 / 2active_not_recruiting
NCT04703686
Treatment by a Bispecific CD3xCD20 Antibody for Relapse/Refractory Lymphomas After CAR T-cells TherapyNo drug interventionstreatment2active_not_recruiting
NCT02950220
Pembrolizumab and Ibrutinib in Treating Patients With Relapsed or Refractory Non-Hodgkin LymphomaNo drug interventionstreatment1completed
NCT06343376
Genetically Engineered Cells (EGFRt/19-28z/IL-12 CAR T Cells) for the Treatment of Relapsed or Refractory CD19+ Hematologic MalignanciesNo drug interventionstreatment1recruiting
NCT03277729
A Phase I/II Study to Evaluate the Safety of Cellular Immunotherapy Using Autologous T Cells Engineered to Express a CD20-Specific Chimeric Antigen Receptor for Patients With Relapsed or Refractory B Cell Non-Hodgkin LymphomasNo drug interventionstreatment1 / 2active_not_recruiting
NCT05936229
Interferon-Beta-1a (FP-1201) to Prevent Toxicities After CD19-Directed CAR T-Cell TherapyNo drug interventionsprevention1 / 2withdrawn
NCT03440567
Avelumab, Utomilumab, Rituximab, Ibrutinib, and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma or Mantle Cell LymphomaNo drug interventionstreatment1active_not_recruiting
NCT04054167
Ultra Low Dose Radiation Delivered Before or After Chemotherapy-Free Targeted Therapy in Treating Patients With Relapsed or Refractory Mantle Cell LymphomaNo drug interventionstreatment2recruiting
NCT04939272
Copanlisib and Venetoclax for the Treatment of Relapsed or Refractory Mantle Cell LymphomaNo drug interventionstreatment1 / 2active_not_recruiting
NCT03479268
Pevonedistat and Ibrutinib in Treating Participants With Relapsed or Refractory CLL or Non-Hodgkin LymphomaNo drug interventionstreatment1active_not_recruiting
NCT01897012
Alisertib and Romidepsin in Treating Patients With Relapsed or Refractory B-Cell or T-Cell LymphomasNo drug interventionstreatment1completed
NCT02489123
Enzalutamide in Treating Patients With Relapsed or Refractory Mantle Cell LymphomaNo drug interventionstreatment2terminated