Chronic Migraine (DBCOND0042084)

Identifiers

Synonyms
Headache Migraine Chronic / Chronic Migraine, Headaches / Chronic Migraine, Headache / Chronic Migraine Headache / Chronic migraine / Chronic Migraine Headaches / Chronic migraine without aura / Transformed migraine (disorder) / Migraine, unspecified / Migraine, unspecified, not intractable, without status migrainosus / Migraine NOS / Migraine headaches / Migraine headache / Migrainous headache / Migraine type headaches / Migraine Disorders / Migraine (disorder) / Migraine

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Botulinum toxin type A
A purified form of botulinum toxin type A used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia, as well as in cosmetic applications.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06450444
The RECLAIM Study.No drug interventionstreatmentNot Availablerecruiting
NCT06625060
A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in AdultsNo drug interventionstreatment2recruiting
NCT03404336
Study on 30 Outpatients With Chronic Migraine Treated With Well-Being Therapy or With a Control TherapyNo drug interventionstreatmentNot Availablerecruiting
NCT04616326
A Study of Galcanezumab (LY2951742) in Participants 12 to 17 Years of Age With Chronic Migrainetreatment3recruiting
NCT05903027
Gepant TreAtments: EffectIveNess and TolERability (GAINER)Not AvailableNot Availablerecruiting
NCT06603558
Post-Marketing Study to Assess the Safety and Effectiveness of Oral Atogepant in Korean Adult Participants for the Prevention of Chronic or Episodic MigraineNot AvailableNot Availablerecruiting
NCT06047444
A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Chronic Migraine in Adultsprevention3recruiting
NCT06219694
Laser Acupuncture for Chronic MigraineNo drug interventionstreatmentNot Availablerecruiting
NCT05843721
Post-marketing Clinical Follow-up for Long-term Use of Intranasal Kinetic Oscillation in Subjects With Chronic MigraineNo drug interventionspreventionNot Availablerecruiting
NCT04271202
Novel Insight Into Migraine Pathophysiolgy and Galcanezumab Mechanisms of Actionbasic_science4active_not_recruiting
NCT04437433
A Study Evaluating Oral Atogepant for the Prevention of Migraine in Japanese Participants With Chronic or Episodic Migrainetreatment3completed
NCT05337033
Cannabis for Chronic Headaches in Adolescents: the CAN-CHA Trialtreatment1recruiting
NCT06309251
Effectiveness and Impact on the Quality of Life of Ketogenic Diet in Pediatric PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT05273151
A Study With Intranasal Kinetic Oscillation Stimulation (KOS) in the Prevention of Chronic MigraineNo drug interventionspreventionNot Availablerecruiting
NCT06122545
Chronic Migraine Prophylaxis: Ultrasound-Guided Greater Occipital Nerve Block Versus Medical TreatmentpreventionNot Availablerecruiting
NCT03919045
Saline Injections for Prophylactic Treatment of Chronic Migrainetreatment4terminated
NCT06409845
Effectiveness and Tolerability of EptinezumabNot AvailableNot Availablerecruiting
NCT02686983
GON-block in Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Studyprevention4unknown_status
NCT02614261
Evaluation of Galcanezumab in the Prevention of Chronic Migrainetreatment3completed
NCT01687088
Smell Sensitivity in Chronic Migraine: A Case-Control StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT04161807
Efficacy and Safety of Nerivio™ for Acute Treatment of Migraine in People With Chronic MigraineNo drug interventionstreatmentNot Availablecompleted
NCT06322407
Ultrasound-guided Stellate Ganglion Block for Treatment of Chronic Migraine in AdulttreatmentNot Availablerecruiting
NCT05730556
A Study of Remote Electrical Neuromodulation for Acute Procedural PainNo drug interventionstreatmentNot Availablerecruiting
NCT05979337
Brief Interventions in Chronic MigraineNo drug interventionstreatmentNot Availablerecruiting
NCT04871152
Trip-Tox, Effectiveness of Triptans Before and After Onabotulinumtoxin A Treatment in Chronic MigraineNot AvailableNot Availableunknown_status
NCT06562400
Searching for Novel Therapeutic Approaches in Migraine Patients Resistant to TreatmentsNo drug interventionsNot AvailableNot Availablerecruiting
NCT03400059
Study to Evaluate the Efficacy of Intranasal Kinetic Oscillation Stimulation in the Preventive Treatment of Chronic MigraineNo drug interventionspreventionNot Availablecompleted
NCT05281770
Monoclonal CGRP Antibodies for Migraine Prevention - a Nationwide Real Life StudyNot AvailableNot Availablerecruiting
NCT02510742
Physiological Changes With SPG Stimulation in Migraine PatientsNo drug interventionstreatmentNot Availablecompleted
NCT05720819
Biofeedback-VR for Treatment of Chronic MigraineNo drug interventionstreatmentNot Availablecompleted
NCT03231241
Analysis of Headache Chronification With Imaging, Deep Phenotyping, and ProteomicsNo drug interventionsNot AvailableNot Availablerecruiting
NCT01804517
Impact of a Nurse for Migraine Management: the IMPACT ProjectNo drug interventionsNot AvailableNot Availablecompleted
NCT03568617
rTMS for the Prevention Treatment of CM: a Single Arm StudyNo drug interventionstreatmentNot Availableunknown_status
NCT01071096
Calcitonin Gene-related Peptide Levels in Chronic Migrainetreatment4completed
NCT06554886
A Study Investigating Peripheral Cryoneurolysis in Adults With Chronic MigraineNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT02202486
Investigation of the Blood-brain and Blood-dura Barrier Durin Migraine Attacks Using MRINo drug interventionsNot AvailableNot Availableunknown_status
NCT01752439
Effects of Transcranial Direct Current Stimulation in Refractory Chronic Migraine and Medication-overuse HeadacheNo drug interventionstreatmentNot Availableunknown_status
NCT01393522
Study Evaluated the Effectiveness of Milnacipran to Reduce Pain Levels in Individuals With Chronic MigrainepreventionNot Availablecompleted
NCT02037425
Duration of Benefit for OnabotulinumtoxinA in Treatment of Chronic Migrainetreatment4completed
NCT01833130
Use of a Treatment Benefit Questionnaire in Patients With Chronic Migraine Treated With OnabotulinumtoxinA (BOTOX®)treatment4completed
NCT05679765
Efficacy of GONB in Patients of Migrainetreatment4completed
NCT00772031
NINDS CRC Chronic Migraine Treatment Trialprevention3completed
NCT02328976
Hypothalamus Connectivity in Chronic and Episodic MigraineNo drug interventionsbasic_scienceNot Availablecompleted
NCT04628429
CGRP Inhibition, Autonomic Function, and MigraineNot AvailableNot Availablerecruiting
NCT05903040
Ditan Acute tReatments: Effectiveness and Tolerability (DART)Not AvailableNot Availablerecruiting
NCT02747940
Neurologic Signatures of Chronic Pain Disordersbasic_science4completed
NCT06461767
Repetitive Transcranial Magnetic Stimulation in Treatment and Prophylaxis of Chronic Migraine in Patients With no Prophylactic Treatment for the Last 3 MonthsNo drug interventionstreatmentNot Availablerecruiting
NCT05568004
The Effect of Exercise on Migraine Attacks in Chronic MigraineNo drug interventionssupportive_careNot Availablecompleted
NCT04324710
Gene Expression of Endocannabinoid System in Episodic and Chronic Migraine PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT03671681
Mindfulness Therapy for Chronic MigraineNo drug interventionstreatmentNot Availableunknown_status
NCT02627014
Effect of Treatment of Temporomandibular Joint in Patients With Chronic Migraine and Temporomandibular DisordersNo drug interventionstreatmentNot Availablecompleted
NCT01496950
Double-blind Randomized Clinical Trial of Transcranial Magnetic Stimulation in Chronic MigraineNo drug interventionstreatment1completed
NCT05598723
BOTOX® vs. XEOMIN® for Chronic Migrainetreatment3recruiting
NCT06155123
HD-EEG Connectivity Changes in Migraine Patients Undergoing Treatment With Anti-CGRP mAbsNot AvailableNot Availablerecruiting
NCT01709708
Use of the Tx360 Nasal Applicator in the Treatment of Chronic Migrainetreatment4completed
NCT06428838
Eptinezumab as an Adjunct to Standard of Care for Migraine in an Acute Emergency Contextprevention3not_yet_recruiting
NCT03453203
Treatment of Cervical Pain in Chronic MigraineNo drug interventionstreatmentNot Availablewithdrawn
NCT03414203
Comparison Between Transcranial Stimulation Protocols With Continuous Current in the Chronic MigraineNo drug interventionstreatmentNot Availablecompleted
NCT05754190
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMANo drug interventionsNot AvailableNot Availablerecruiting
NCT05933590
Cervical Repositioning Error in Chronic MigraineNo drug interventionsNot AvailableNot Availablecompleted
NCT04361721
Neurophysiological, Biomolecular and Psychological Aspects of Erenumab Treatment in Chronic MigraineNot AvailableNot Availableunknown_status
NCT01135784
Study of MIGRA-ZEN RELIEF PLUS In the Treatment of Chronic Migraine HeadacheNo drug interventionsprevention2unknown_status
NCT05328687
Examination of Muscle Stiffness, Tenderness and Pressure Pain Thresholds During a Cycle of Botulinum Toxin A Treatment in Chronic Migraine PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT01151787
Efficacy and Safety of Cyclobenzaprine Hydrochloride Extended Release for the Treatment of Chronic Migraineprevention3terminated
NCT01700387
A Study to Evaluate the Tolerability of Botox and Topiramate or Botox and Placebo and Effect on Cognitive Efficiencytreatment4completed
NCT01314651
Efficacy of Behavioral Insomnia Treatment for Chronic MigraineNo drug interventionstreatmentNot Availablecompleted
NCT04829747
Study to Assess Adverse Events (AEs) When Oral Atogepant Tablet is Given to Adult Chinese Participants Who Completed Study 3101-303-002 to Prevent Chronic Migraineprevention3completed
NCT02639598
Flunarizine Versus Topiramate for Chronic Migraine Prophylaxistreatment4completed
NCT04353505
Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headachetreatment1withdrawn
NCT01257893
Aspirin Resistance in Women With MigrainescreeningNot Availablewithdrawn
NCT02307071
Occipital Transcutaneous Stimulation in Chronic MigraineNo drug interventionstreatment4unknown_status
NCT04976985
Osteopathic Manipulative Treatment and Migraine HeadachesNo drug interventionstreatmentNot Availableunknown_status
NCT04715685
Mind Body Balance for Pediatric MigraineNo drug interventionstreatmentNot Availablerecruiting
NCT03855137
Efficacy, Safety, and Tolerability of Atogepant for the Prevention of Chronic Migrainetreatment3completed
NCT02122237
Cathodal tDCS in Chronic Migraine: Neurophysiological Study and Pilot Therapeutic TrialNo drug interventionstreatment3completed
NCT06409832
RimegepAnt effectIvenesS and tolErability as Migraine Preventive TreatmentNot AvailableNot Availablerecruiting
NCT05517200
Pilot Study for a Machine Learning Test for MigraineNo drug interventionsNot AvailableNot Availablerecruiting
NCT03507400
Introvision for Migraine and HeadachesNo drug interventionspreventionNot Availableunknown_status
NCT05079659
Rate , Predictors and Outcome of Chronic MigraineNo drug interventionsNot AvailableNot Availableunknown_status
NCT05226559
Effectiveness of Multimodal Physical Therapy in MigraineNo drug interventionstreatmentNot Availablerecruiting
NCT06549270
Biochemical Profiling of Migraine PatientsNot AvailableNot Availablerecruiting
NCT02436499
Chronic Migraine Treatment With Botulinum Toxin-A: an Investigation of Functional Magnetic Resonance Imaging Changes.treatment4completed
NCT04686136
A Long-Term Safety and Tolerability Extension Study Evaluating Atogepant for the Prevention of Chronic or Episodic Migrainetreatment3active_not_recruiting
NCT06485336
Prophylactic Treatment With Atorvastatin for Chronic Migraine (ChronicStatinMig)prevention2recruiting
NCT06562413
Searching for Novel Biological Phenotypes in Migraine Patients Resistant to TreatmentsNot AvailableNot Availablerecruiting
NCT03972124
Cannabis for the Prophylactic Treatment of MigraineNo drug interventionsprevention2not_yet_recruiting
NCT05889624
Responding With Evidence and Access for Childhood HeadachestreatmentNot Availablerecruiting
NCT03175263
OnabotulinumtoxinA Injections in Chronic Migraine, Targeted to Sites of Pericranial Myofascial PainNo drug interventionsNot AvailableNot Availablecompleted
NCT00884663
Candesartan Versus Propranolol for Migraine Preventiontreatment2 / 3completed
NCT05216263
Study of Oral Atogepant When Added to OnabotulinumtoxinA (BOTOX) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Chronic Migrainetreatment3recruiting
NCT01319825
Preventive Treatment of Episodic and Chronic Migraineprevention4unknown_status
NCT05769348
Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in Vivo)No drug interventionstreatmentNot Availablerecruiting
NCT02514148
Biobehavioral Physical Therapy Strategies Based on Therapeutic Exercise Applied to Chronic Migraine PatientsNo drug interventionstreatmentNot Availablecompleted
NCT03395457
Tertiary Care With or Without Manual Therapy for Chronic MigraineNo drug interventionstreatmentNot Availablecompleted
NCT05415020
Determining the Utility of a Behavioral Intervention in Chronic MigraineNo drug interventionstreatmentNot Availablerecruiting
NCT02021773
Assessment of LBR-101 In Chronic Migraineprevention2completed
NCT02188394
Anesthetic Blockades and Migrainetreatment2completed
NCT01813591
A Two-Arm Study Evaluation H.P. Acthar Injection Gel in Treatment of Chronic Migrainestreatment2completed
NCT01720862
Migraine and Body CompositionNo drug interventionsNot AvailableNot Availablecompleted
NCT02291380
A Study to Evaluate Botulinum Toxin Type A for Injection(HengLi®)for Prophylactic Treatment of Chronic Migrainetreatment3unknown_status
NCT06414044
Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine PatientsNot AvailableNot Availablerecruiting
NCT02122744
RCT Versus Placebo of rTMSQP Over Visual Cortex for the Prevention of Chronic MigraineNo drug interventionspreventionNot Availablewithdrawn
NCT04788667
Effectiveness of a Health Education Programme for Prevention of Chronic Migraine: A Randomized Clinical TrialNo drug interventionstreatmentNot Availablecompleted
NCT04336267
Anodal tDCS in Chronic Migraine With Medication OveruseNo drug interventionstreatmentNot Availablecompleted
NCT05858801
First Evaluation of a Craniofacial Peripheral Nerve Stimulation System in Chronic MigraineNo drug interventionsdevice_feasibilityNot Availableactive_not_recruiting
NCT03108469
Efficacy and Safety of IONIS-PKKRx for Preventive Treatment of Chronic MigraineNo drug interventionstreatment2completed
NCT01741246
Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance ImagingNo drug interventionsNot AvailableNot Availablecompleted
NCT06170281
Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral TrialNo drug interventionstreatmentNot Availablerecruiting
NCT05893914
Intramuscular Electrical Stimulation for the Treatment of Trigger Points in Patients With MigraineNo drug interventionstreatmentNot Availablerecruiting
NCT01090050
Treximet in the Treatment of Chronic Migrainetreatment4completed
NCT01667250
Non-Invasive Neurostimulation for the Prevention of Chronic MigraineNo drug interventionspreventionNot Availablecompleted
NCT05536050
Study of Low-dose Naltrexone in Chronic Migraine With FibromyalgiaNo drug interventionsNot AvailableNot Availablerecruiting
NCT05679908
A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraineprevention2completed
NCT04194008
Efficacy and Safety of Nerivio Device for Acute Treatment of Migraine in People With Chronic MigraineNo drug interventionstreatmentNot Availablecompleted
NCT05891808
miR-155 Expression in Episodic and Chronic MigraineNo drug interventionsNot AvailableNot Availablerecruiting
NCT04961671
Effectiveness, Safety, and Tolerability of Analgesics in the Prevention of Chronic Migrainetreatment3completed
NCT05888298
Proximal and Distal Approach GON RFT in MigraineNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT02720211
Spectacle Tints and Thin-Films for MigraineNo drug interventionstreatmentNot Availableterminated
NCT01749410
A Retrospective Study to Evaluate the Effectiveness and Benefit of onabotulinumtoxinA in Patients With Chronic MigrainesNot AvailableNot Availablecompleted
NCT05313503
KETOMIGRAINE: Ketogenic Diet in Drug-resistant Chronic MigraineursNo drug interventionstreatmentNot Availableunknown_status
NCT05724771
COACT Study: CGRPmAbs + OnabotulinumtoxinA Assessment of Chronic Migraine Treatments Studytreatment4active_not_recruiting
NCT06138171
Personality, Defences, Central Sensitization, and Trauma in Women With Chronic Migraine, Fibromyalgia, and VulvodyniaNo drug interventionsNot AvailableNot Availablerecruiting
NCT04989413
Cannabidiol 133mg + Cannabigerol 66mg + Tetrahydrocannabinol 4mg vs Placebo as Adjuvant Treatment in Chronic Migraine -treatment4recruiting
NCT05700318
Study Using the ShiraTronics Migraine Therapy SystemNo drug interventionstreatmentNot Availablerecruiting
NCT06342219
Chronic Migraines and Neurofdeeback MindfulnessNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT04017741
A Study Investigating the Efficacy of GON Blocks.prevention4completed
NCT04520425
Osteopathic Manipulative Techniques for the Treatment of Chronic Migraine HeadachesNo drug interventionstreatmentNot Availableterminated
NCT04349176
Onabotulinum Dose Comparison in Chronic Migraine Superior to 100 Units?No drug interventionstreatment3terminated
NCT06133491
Open Label, 6-month Study for High Frequency and Chronic Migraine,No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT06109389
The Efficacy Of Lidocaine Infusion IN Chronic Unilateral Migraine Headachetreatment2active_not_recruiting
NCT06247592
Pulse Radiofrequency and Occipital Nerve Block for Chronic Migraine PatientsNo drug interventionstreatmentNot Availablerecruiting
NCT05381012
Fibromyalgia Syndrome on Patients With Chronic MigraineNo drug interventionsdiagnosticNot Availablecompleted
NCT01749423
A Retrospective Study to Evaluate the Effectiveness of onabotulinumtoxinA in Preventing Headaches in Patients With Chronic MigrainesNot AvailableNot Availablewithdrawn
NCT06118190
Mesotherapy in the Treatment of Chronic MigraineNo drug interventionstreatmentNot Availablecompleted
NCT04064879
The Use of Autologous Mesenchymal Stem Cell Preparation for Treatment of Refractory MigraineNo drug interventionstreatmentNot Availablesuspended
NCT03698409
Onabotulinumtoxin Type A Reconstitution With Preserved Versus Preservative-free Saline in Chronic Migraine.treatment4completed
NCT05748535
Effect of Auricular Vagus Nerve Stimulation in Women With Migraine DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT03465826
Developing a Mobile Health Pain-Coping Skills Training Program for the Treatment of Chronic Migraine: AIM 4No drug interventionsotherNot Availablewithdrawn
NCT03526874
Occipital Blocks for Acute Migrainetreatment3completed
NCT03767062
Peripheral Nerve Block and Topiramate in the Treatment of Medication Overuse HeadachestreatmentNot Availablecompleted
NCT05381129
The Effect of Accompanying Temporomandibular Joint Dysfunction in Patients With Chronic MigraineNo drug interventionsdiagnosticNot Availablecompleted
NCT05464212
Comparison of the Efficacy of Ultrasound-guided Greater Occipital Nerve Block and Pulsed Radiofrequency Therapy in Chronic Migraine PatientsNo drug interventionstreatmentNot Availablecompleted
NCT04871581
Adjunctive Treatment of Chronic Migraine Using an Oral Dental DeviceNo drug interventionspreventionNot Availablecompleted
NCT00200109
Occipital Nerve Stimulation for the Treatment of Chronic Migraine Headache.No drug interventionsNot Available1completed