Advanced Hepatocellular Carcinoma (HCC) (DBCOND0046987)

Identifiers

Synonyms
Advanced Hepatocellular Carcinoma

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Durvalumab
An antineoplastic monoclonal antibody used to treat urothelial carcinoma and locally advanced, unresectable non-small cell lung cancer.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT02906397
Galunisertib (LY2157299) Plus Stereotactic Body Radiotherapy (SBRT) in Advanced Hepatocellular Carcinoma (HCC)treatment1completed
NCT02814461
The Safety and Maximum Tolerated Dose of Axitinib in Combination With Radiotherapy for HCCtreatment1completed
NCT06309485
Phase 2 Study of WGI-0301 for Advanced HCCtreatment2not_yet_recruiting
NCT04212221
MGD013 Monotherapy and Combination With Brivanib Dose Escalation and Expansion Study in Advanced Liver Cancer Patientstreatment1 / 2terminated
NCT04523493
Phase III Study of Toripalimab(JS001) Combined With Lenvatinib for Advanced HCCtreatment3active_not_recruiting
NCT01101906
A Randomized, Placebo-controlled, Double-blind Phase 2 Study With OSI-906 in Patients With Advanced HCCtreatment2terminated
NCT04985136
A Study of Camrelizumab Combined With Rivoceranib Mesylate Versus Investigator's Choice of Regimen in Treatment of Patients With Advanced Hepatocellular Carcinoma (HCC)treatment3terminated
NCT04605796
A Single-arm, Open-label, Multi-center Phase II Clinical Study to Evaluate the Safety and Efficacy of Toripalimab Injection (JS001) Combined With Bevacizumab as the First-line Therapy for Advanced Hepatocellular Carcinoma (HCC)treatment2unknown_status
NCT04344158
A Phase III Clinical Trial of AK105 Injection Combined With Anlotinib Hydrochloride Capsules Versus Sorafenib in Subjects With Advanced Hepatocellular Carcinoma (HCC)treatment3not_yet_recruiting
NCT04723004
Evaluate the Safety and Efficacy of Toripalimab Combined With Bevacizumab Versus Sorafenib Therapy for HCCtreatment3active_not_recruiting
NCT05375604
A Study of exoASO-STAT6 (CDK-004) in Patients With Advanced Hepatocellular Carcinoma (HCC) and Patients With Liver Metastases From EIther Primary Gastric Cancer or Colorectal Cancer (CRC)No drug interventionstreatment1terminated
NCT02509169
Trans-catheter Arterial Embolization Combined With p53 Gene Therapy for Treatment of Advanced Hepatocellular CarcinomaNo drug interventionstreatment2unknown_status
NCT05862181
The Comparison Between HepaSphere Drug-eluting Bead Transarterial Chemoembolization Combined With Hepatic Arterial Infusion Chemotherapy in Advanced Hepatocellular CarcinomaNo drug interventionsNot AvailableNot Availablerecruiting
NCT06600321
A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinomatreatment1recruiting
NCT06644430
Ablation of Pulmonary Oligometastasis Combined With System for Advanced Hepatocellular CarcinomaNo drug interventionsNot AvailableNot Availablerecruiting
NCT04514484
Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIVtreatment1active_not_recruiting
NCT06618664
Study of SHR-8068 Combined With Adebrelimab and Bevacizumab Versus Sintilimab Combined With Bevacizumab for the Treatment of Advanced Hepatocellular Carcinomatreatment3not_yet_recruiting
NCT06624098
Early Transjugular Intrahepatic Portosystemic Shunt for Advanced Hepatocellular CarcinomaNo drug interventionstreatmentNot Availablerecruiting
NCT05092373
Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thoraxtreatment1recruiting
NCT05883644
Durvalumab and Tremelimumab as First Line Treatment in Participants With Advanced Hepatocellular Carcinoma (HCC)treatment3recruiting
NCT06427941
A Phase 1 Study of BGB-B2033, Alone or in Combination With Tislelizumab, in Participants With Advanced or Metastatic Solid Tumorstreatment1recruiting
NCT04740307
Safety and Efficacy of Coformulated Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib (E7080/MK-7902) in Advanced Hepatocellular Carcinoma (MK-1308A-004)treatment2active_not_recruiting
NCT06609863
dTACE-HAIC Combined With Bevacizumab and Atezolizumab for Huge Hepatocellular CarcinomaNo drug interventionstreatmentNot Availablerecruiting
NCT06595108
ATezolizumab and BEvacizumab With STereotactic Body Radiotherapy for Advanced Hepatocellular CarcinomaNo drug interventionstreatmentNot Availablerecruiting
NCT06550921
Ablation of Oligometastasis Combined With Lenvatinib and PD-1 Inhibitor for Advanced Hepatocellular CarcinomaNo drug interventionstreatmentNot Availablerecruiting
NCT05213221
Study on Therapeutic Effect of Combination of Envafolimab, Lenavatinib and TACE in Advanced HCC Patientstreatment2completed
NCT04072679
Safety and Efficacy Study of Sintilimab Combined With IBI305 in Patients With Advanced Hepatocellular Carcinomatreatment1completed
NCT01214343
Comparing Efficacy of Sorafenib Versus Sorafenib in Combination With Low-dose FP in Patients With Advanced HCCtreatment3unknown_status
NCT05028933
IMC001 for Clinical Research on Advanced Digestive System MalignanciesNo drug interventionstreatment1recruiting
NCT04101747
To Explore the Diversity of Intestinal Flora in Patients With Advanced HCC Combin ed With Anti-PD-1 and Targeted Drug Therapy and the Correlation Between Metabolites and Therapeutic EffectNo drug interventionsNot AvailableNot Availableunknown_status
NCT05975645
A Clinical Study of TQB2618 Injection Combined With Penpulimab Injection and Anlotinib Hydrochloride Capsules for First-line Treatment of Advanced Hepatocellular Carcinoma (HCC).treatment1recruiting
NCT04973098
Phase I Clinical Trial of CT0181 Cells in the Treatment of Hepatocellular CarcinomaNo drug interventionstreatment1unknown_status
NCT05173298
Predictive Biomarkers in Patients With Advanced Hepatocellular Carcinoma Treated With Atezolizumab Plus BevacizumabNot AvailableNot Availablerecruiting
NCT05773105
A Study of Cadonilimab Combined With Regorafenib in Patients With Advanced HCCtreatment1 / 2active_not_recruiting
NCT05797805
A Study of Tegavivint (BC2059) in Patients With Advanced Hepatocellular Carcinomatreatment1 / 2recruiting
NCT05924997
Adebrelimab, Camrelizumab Plus Apatinib as First-line Therapy in Patients With Advanced Hepatocellular Carcinomatreatment1 / 2recruiting
NCT05592197
Safety and Efficacy of Radiation Plus TACE and Lenvatinib in Advanced HCC With PVTTtreatmentNot Availablewithdrawn
NCT01429961
Trial of Palliative Chemotherapy With TS-1 and Oxaliplatin for Patients With Advanced Hepatocellular CarcinomaNo drug interventionstreatment2unknown_status
NCT01356628
A Clinical Research Study to Determine Whether PD 0332991 May Be Effective in Treating Patients With Liver Cancertreatment2active_not_recruiting
NCT00667628
Phase 2 Study of TAC-101 Combined With Transcatheter Arterial Chemoembolization (TACE) Versus TACE Alone in Japanese Patients With Advanced Hepatocellular CarcinomaNo drug interventionstreatment2terminated
NCT01192971
A Study of Apatinib in Patients With Advanced Hepatocellular Carcinomatreatment2completed
NCT04730388
ATEZOLIZUMAB - BEVACIZUMAB in the Treatment Hepatocellular Carcinoma Inoperable orNo drug interventionsNot AvailableNot Availableunknown_status
NCT05070156
B010-A Injection for Treating Patients With GPC3 Positive Advanced Hepatocellular CarcinomaNo drug interventionstreatment0active_not_recruiting
NCT05718232
SBRT Plus Lenvatinib and TACE for Advanced Primary HCC: A Phase 3 Trial (SEARCH)treatment3not_yet_recruiting
NCT04052152
Anlotinib Hydrochloride Combined With Sintilimab Injection in the Treatment of Advanced Hepatocellular Carcinoma (HCC)treatment2unknown_status
NCT06418659
A Clinical Trial Evaluating the Safety and Efficacy of Intravenous CD-801 in Treating Advanced HCC PatientsNo drug interventionstreatment0not_yet_recruiting
NCT05352542
GPC3-targeting CART Cell in Treatment of Advanced Hepatocellular CarcinomaNo drug interventionstreatment1terminated
NCT03605706
A Trial of SHR-1210 (an Anti-PD-1 Inhibitor) in Combination With FOLFOX4 in Subjects With Advanced HCC Who Have Never Received Prior Systemic Treatment.treatment3unknown_status
NCT04862949
Organ-specific Responses to Atezolizumab Plus Bevacizumab in Advanced HCCNot AvailableNot Availablecompleted
NCT04401813
Efficacy and Safety of IBI310 Combined With Sintilimab in Patients With Advanced Hepatocellular Carcinomatreatment1active_not_recruiting
NCT01539018
Sorafenib Plus Tegafur-uracil (UFT) Versus Sorafenib as First Line Systemic Treatment for Patients With Advanced Stage HCC, Unresectable & Not Eligible for Local Ablation and/or TACEtreatment2terminated
NCT05317819
Study of ADI-PEG 20 Versus Placebo in Subjects With High Arginine Level and Unresectable Hepatocellular Carcinomatreatment3recruiting
NCT00752063
Sorafenib With Capecitabine and Oxaliplatin for Advanced or Metastatic Hepatocellular Carcinomatreatment2unknown_status
NCT04828486
Futibatinib and Pembrolizumab for Treatment of Advanced or Metastatic FGF19 Positive BCLC Stage A, B, or C Liver Cancertreatment2recruiting
NCT04756648
Phase I Clinical Trial of CT0180 Cells in the Treatment of Hepatocellular CarcinomaNo drug interventionstreatment1recruiting
NCT05791448
AU409 for the Treatment of Advanced Primary Liver Cancers or Solid Tumor With Liver Metastatic DiseaseNo drug interventionstreatment1recruiting
NCT02638857
Immunotherapy Using Precision T Cells Specific to Multiple Common Tumor-Associated Antigen Combined With Transcatheter Arterial Chemoembolization for the Treatment of Advanced Hepatocellular Carcinomatreatment1 / 2unknown_status
NCT06370065
Serplulimab Combined With Bevacizumab Biosimilar and HAIC in Advanced Hepatocellular Carcinoma (HCC) Patientstreatment2recruiting
NCT01656265
Study of ARQ 197 in Hepatocellular Carcinoma (HCC)treatment1completed
NCT04611165
Concurrent Nivolumab and External Beam Radiation Therapy for Patients With Advanced HCCtreatment2unknown_status
NCT00241020
Evaluation of the Efficacy of Long-acting Release Octreotide in Patients With Advanced Hepatocellular Carcinomatreatment3completed
NCT00756782
A Study of TAC-101 in Combination With TACE Versus TACE Alone in Asian Patients With Advanced Hepatocellular CarcinomaNo drug interventionstreatment2withdrawn
NCT00999882
Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Efficacy of Tor Kinase Inhibitor in Liver Cancer Patientstreatment1completed
NCT03586973
A Phase 2 Study of Cabozantinib in Japanese Participants With Advanced Hepatocellular Carcinomatreatment2completed
NCT06233994
A Study Evaluating the Efficacy and Safety of ZG005 in Combination With Donafenib or Bevacizumab in Patients With Advanced Hepatocellular CarcinomatreatmentNot Availablenot_yet_recruiting
NCT04709380
Phase III RCT of Radiotherapy Plus Toripalimab Versus Sorafenib in Advanced Hepatocellular Carcinoma With PVTTtreatment3recruiting
NCT06320080
Clinical Study of TQB2223 Injection Combined With AK105 Injection in the Treatment of Advanced Hepatocellular Carcinoma.treatment1not_yet_recruiting
NCT03905967
TACE With Lenvatinib Versus Lenvatinib Alone in in First-line Treatment of Advanced HCCtreatment3unknown_status
NCT00882869
XIAP Antisense AEG35156 in Combination With Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC)treatment1 / 2completed
NCT00872014
A Study of the Effectiveness and Safety of AMG 386 and Sorafenib to Treat Advanced or Inoperable Hepatocellular Cancertreatment2completed
NCT05176223
68Ga PSMA PET Imaging for the Treatment of Advanced Liver Cancertreatment2recruiting
NCT04777708
BO-112 and Pembrolizumab for the Treatment of PD-1/PD-L1 Refractory Liver Cancertreatment0terminated
NCT02528643
A Study to Assess the Efficacy and Safety of Enzalutamide in Subjects With Advanced Hepatocellular Carcinomatreatment2completed
NCT03993743
A Study of CD147-targeted CAR-T by Hepatic Artery Infusions for Very Advanced Hepatocellular CarcinomaNo drug interventionstreatment1unknown_status
NCT00534664
Phase I/II Study of Amplitude-Modulated Electromagnetic Fields in the Treatment of Advanced Hepatocellular CarcinomaNo drug interventionstreatment1 / 2completed
NCT04417764
TACE Combined With PD-1 Knockout Engineered T Cell in Advanced Hepatocellular Carcinoma.No drug interventionstreatment1recruiting
NCT06326502
A Safety and Efficacy Study of Multiple Tyrosine Kinase Inhibitor Drug (ETN101) in Advanced Hepatocellular CarcinomaNo drug interventionstreatment1recruiting
NCT05845502
Single-arm, Open-label Clinical Study of SZ003 in the Treatment of Advanced Hepatocellular CarcinomaNo drug interventionstreatmentNot Availablerecruiting
NCT04503902
Toripalimab Combined With Donafenib in the Treatment of Advanced Hepatocellular Carcinomatreatment1 / 2recruiting
NCT03059147
Phase 1 Study of SF1126 in Combination With Nivolumab in Patients With Advanced Hepatocellular Carcinomatreatment1terminated
NCT05057845
Cryoablation Combined With Tislelizumab Plus Lenvatinib as Second-line or Later Therapy in Advanced Hepatocellular Carcinomatreatment2recruiting
NCT05628545
Adoptive Treatment of Advanced Hepatocellular Carcinoma With Allogeneic γδ-T CellsNo drug interventionstreatment1 / 2withdrawn
NCT00731445
Phase I/II Study of Z-208 in Advanced Hepatocellular Carcinoma (HCC)No drug interventionstreatment1 / 2completed
NCT04294498
Durvalumab for Advanced Hepatocellular Carcinoma in Patients With Active Chronic Hepatitis B Virus Infectiontreatment2active_not_recruiting
NCT04948697
A Study Investigating the Efficacy and Safety of Ociperlimab and Tislelizumab and BAT1706 Combinations in Patients With Advanced HCCtreatment2completed
NCT01942083
A Phase I, Open Label, Non Randomized, Multicenter, Dose Escalation Clinical Study to Investigate Safety and Tolerability of OPB(Otsuka Pharmaceutical Biwa)-111077 in Subjects With Advanced HCC(Hepatocellular Carcinoma)treatment1terminated
NCT05097911
Phase I Study of RNA Oligonucleotide, MTL-CEBPA, Atezolizumab and Bevacizumab in Patients With Advanced Hepatocellular Carcinoma.treatment1recruiting
NCT05444088
Study of SHR-8068 Combined With Adebrelimab and Bevacizumab in the Treatment of Advanced Hepatocellular Carcinomatreatment1 / 2recruiting
NCT04183088
Regorafenib Plus Tislelizumab as First-line Systemic Therapy for Patients With Advanced Hepatocellular Carcinomatreatment2recruiting
NCT03980288
4th Generation Chimeric Antigen Receptor T Cells Targeting Glypican-3No drug interventionstreatment1completed
NCT06470256
Palliative Hepatectomy Combined With Targeted Therapy and Immunotherapy for Advanced Hepatocellular Carcinomatreatment1recruiting
NCT04358185
Itacitinib in Advanced Hepatocellular Carcinomatreatment1active_not_recruiting
NCT06374485
Study of AU409 Capsule in Advanced Hepatocellular Carcinoma Patients Who Failed Standard TreatmentNo drug interventionstreatment1recruiting
NCT04000737
YIV-906 (Formerly PHY906/KD018) With Sorafenib in HBV(+) Hepatocellular Carcinoma (HCC)treatment2unknown_status
NCT04430452
Hypofractionated Radiotherapy Followed by Durvalumab With or Without Tremelimumab for Liver Cancer After Progression on PD-1 Inhibitiontreatment2recruiting
NCT01129570
Siliphos in Advanced Hepatocellular Carcinomatreatment1completed
NCT05783570
To Evaluate the Safety, Tolerability and Preliminary Efficacy of EU307No drug interventionstreatment1recruiting
NCT06301399
Rituximab Combined With Prior Therapy in Advanced Hepatocellular Carcinoma: Efficacy & Safety Studytreatment2not_yet_recruiting
NCT05620706
Study of GPC-3 CAR-T Cells in Treating With Hepatocellular CarcinomaNo drug interventionstreatmentNot Availablerecruiting
NCT02632006
Immunotherapy Using Pluripotent Killer-Programmed Cell Death 1 (PIK-PD-1) Cells for the Treatment of Advanced Hepatocellular CarcinomaNo drug interventionstreatment1 / 2unknown_status
NCT02150317
Transarterial Chemoembolization (TACE) Plus Sorafenib Versus TACE for Advanced Hepatocellular CarcinomaNo drug interventionstreatmentNot Availableunknown_status
NCT06461624
Clinical Trial of Autologous GPC3 CAR-T Cells (CBG166) Therapy for Advanced Hepatocellular CarcinomaNo drug interventionstreatment1not_yet_recruiting
NCT05738616
Lenvatinib Combined With TACE and Camrelizumab in Conversion Resection for Advanced Hepatocellular Carcinoma (LEN-TAC Study)treatment3recruiting
NCT01964235
Study of Efficacy and Safety INC280 in Patients With Advanced Hepatocellular Carcinomatreatment2withdrawn
NCT06363825
A Study of TAE+HAIC Combined With Camrelizumab and Apatinib in the Treatment of Advanced Hepatocellular Carcinomatreatment2recruiting
NCT05117957
Efficacy and Safety of Sorafenib in Previously Treated Advanced Hepatocellular Carcinoma: SOPT Studytreatment2enrolling_by_invitation
NCT05981066
A Clinical Study of mRNA Vaccine (ABOR2014/IPM511) in Patients With Advanced Hepatocellular CarcinomaNo drug interventionstreatmentNot Availablerecruiting
NCT05290220
HLX07 Combination Therapy or Motherapy in Patient With Advanced Hepatocellular Carcinomatreatment2not_yet_recruiting
NCT00517920
Phase 2 Study of ABT-869 in Advanced Hepatocellular Carcinoma (HCC)treatment2completed
NCT06323382
Locoregional Therapy Combined With Bevacizumab and PD1/L1 Inhibitor in Advanced Hepatocellular CarcinomaNot AvailableNot Availablerecruiting
NCT04066660
Study of Oligo-Fucoidan in Advanced Hepatocellular Carcinoma (HCC)No drug interventionssupportive_careNot Availablesuspended
NCT02834780
Phase 1 Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of H3B-6527 in Participants With Advanced Hepatocellular Carcinomatreatment1completed
NCT02795429
Phase Ib/II Study of INC280 + PDR001 or PDR001 Single Agent in Advanced HCCtreatment1 / 2completed
NCT01033240
CS1008- in Combination With Sorafenib Compared to Sorafenib Alone in Subjects With Advanced Liver Cancertreatment2completed
NCT02724267
Targeted Internal Radiation Therapy in Advanced HCC Patients.No drug interventionstreatmentNot Availablecompleted
NCT03841201
Immunotherapy With Nivolumab in Combination With Lenvatinib for Advanced Stage Hepatocellular Carcinomatreatment2completed
NCT05620004
Safety and Efficacy of Bifidobacterium Therapy in Patients With Advanced Liver Cancer Receiving Immunotherapytreatment1 / 2recruiting
NCT04487704
Camrelizumab Utilization on Patients With Advanced Liver CancerNo drug interventionstreatmentNot Availablerecruiting
NCT06244446
Efficacy and Safety of SBRT Combined With Atezolizumab Plus Bevacizumab vs Atezolizumab Plus Bevacizumab in Treating Unresectable Advance Hepatocellular Carcinoma.No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00495846
GH, IGF-I and Somatostatin Analogues in Hepatocellular Carcinomatreatment2 / 3completed
NCT06092112
A Clinical Trial for the Safety and Efficacy of CD-801 in Patients With Advanced Hepatocellular CarcinomaNo drug interventionstreatment0not_yet_recruiting
NCT01897610
Efficacy and Safety of 'Immuncell-LC Group' and 'Non-treatment Group' in Nexavar Treated Patients for Advanced HCCNo drug interventionstreatment2completed
NCT04442581
Cabozantinib and Pembrolizumab for the First-Line Treatment of Advanced Liver Cancertreatment2terminated
NCT02227914
Phase 1b/2 Study of Oprozomib in Combination With Sorafenib in Subjects With Advanced Hepatocellular Carcinomatreatment1 / 2withdrawn
NCT04331743
A Study to Evaluate the Safety and Efficacy of PLM60 in Advanced HCCtreatment1unknown_status