Chronic Hepatitis C Genotype 1 (DBCOND0053690)

Identifiers

Synonyms

Chronic Hepatitis C, Genotype 1 / Genotype 1 chronic hepatitis C infection / Genotype 1 Chronic Hepatitis C / Chronic Hepatitis C Virus (HCV Infection Genotype 1) / Chronic Hepatitis C, HCV Genotype 1 / Chronic Hepatitis C Virus (HCV) Infection Genotype 1 / Genotype 1 / Chronic hepatitis C genotype 1 / Carrier of viral hepatitis C / Chronic hepatitis C (disorder) / Chronic viral hepatitis C / Hepatitis C, Chronic / Chronic hepatitis C

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Asunaprevir	An NS3 protease inhibitor used to treat hepatitis C genotype 1b.	Genome polyproteintarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 2B1transporter ATP-dependent translocase ABCB1transporter Gag-Pol polyproteintarget
Boceprevir	A hepatitis C virus NS3/4A protease inhibitor used in combination with other medications to treat chronic hepatitis C genotype 1 infection. Boceprevir is not indicated as monotherapy.	Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme ATP-dependent translocase ABCB1transporter Genome polyproteintarget Genome polyproteintarget
Daclatasvir	A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents.	Nonstructural protein 5Atarget Cytochrome P450 3A5enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A43enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Genome polyproteintarget
Elbasvir	An antiviral and NS5A inhibitor used to treat hepatitis C infections.	Nonstructural protein 5Atarget ATP-dependent translocase ABCB1transporter Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Cytochrome P450 3A43enzyme
Glecaprevir	A Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C.	Cytochrome P450 3A Subfamilyenzyme UDP-glucuronosyltransferase 1A1enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter NS3 proteasetarget Cytochrome P450 3A4enzyme Genome polyproteintarget
Grazoprevir	An antiviral and NS3/4A protease inhibitor used to treat hepatitis C infections.	ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Cytochrome P450 3A4enzyme Genome polyproteintarget Albumincarrier Alpha-1-acid glycoprotein 1carrier
Ledipasvir	A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents.	Nonstructural protein 5Atarget ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Genome polyproteintarget
Pibrentasvir	A Hepatitis C NS5A inhibitor used to treat Hepatitis C.	Nonstructural protein 5Atarget Cytochrome P450 3A Subfamilyenzyme UDP-glucuronosyltransferase 1A1enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter
Simeprevir	A direct-acting antiviral agent that inhibits HCV NS3/4A protease to treat chronic hepatitis C virus (HCV) infection in adults with HCV genotype 1 or 4.	NS3 proteasetarget Albumincarrier Cytochrome P450 1A2enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Cytochrome P450 3A4enzyme ATP-binding cassette sub-family C member 2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 2B1transporter Hepatic sodium/bile acid cotransportertransporter Bile salt export pumptransporter Genome polyproteintarget Genome polyproteintarget
Sofosbuvir	A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents.	ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter RNA-dependent RNA-polymerasetarget Lysosomal protective proteinenzyme Carboxylesteraseenzyme Adenosine 5'-monophosphoramidase HINT1enzyme UMP-CMP kinaseenzyme Nucleoside diphosphate kinase Aenzyme Genome polyproteintarget
Telaprevir	An NS3/4A viral protease inhibitor used in combination with other antivirals for the curative treatment of chronic Hepatitis C Virus infections.	Cytochrome P450 3A4enzyme Genome polyproteintarget ATP-dependent translocase ABCB1transporter Albumincarrier Alpha-1-acid glycoprotein 1carrier Solute carrier organic anion transporter family member 1B1target Solute carrier organic anion transporter family member 2B1target Genome polyproteintarget
Velpatasvir	A NS5A inhibitor used to treat chronic hepatitis C infections in patients without cirrhosis or with compensated cirrhosis.	Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 3A4enzyme Nonstructural protein 5Atarget ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 2B1transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02399345	Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir Co-Administered With Sofosbuvir With and Without Ribavirin in Treatment-Naive HCV Genotype 1-Infected Adults	Dasabuvir Ombitasvir Paritaprevir Ribavirin Ritonavir Sofosbuvir	treatment	3	completed
NCT02219490	A Study to Evaluate Long-term Outcomes Following Treatment With ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 With or Without Ribavirin (RBV) in Adults With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection	Dasabuvir Ombitasvir Paritaprevir Ribavirin Ritonavir	treatment	3	completed
NCT02167945	A Study to Evaluate Long-term Outcomes Following Treatment With ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 With or Without Ribavirin (RBV) in Adults With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection	Dasabuvir Ombitasvir Paritaprevir Ribavirin Ritonavir	treatment	3	completed
NCT00152581	Analysis of the Duration of Combination Therapy That is Necessary for HCV Genotype 1 Eradication	Peginterferon alfa-2a Ribavirin	treatment	4	completed
NCT00910975	Individualized Duration of Peg-interferon/Ribavirin Treatment of Hepatitis C	Peginterferon alfa-2a Ribavirin	treatment	4	completed
NCT01425203	The Effect of Boceprevir in Russian Participants Diagnosed With Chronic Hepatitis C Genotype 1 (P08160)	Boceprevir Peginterferon alfa-2b Ribavirin	treatment	3	completed
NCT04246723	Efficacy and Safety of All-Oral Combination of Narlaprevir/Ritonavir and Sofosbuvir in Treatment-naïve Patients With Chronic Hepatitis C Genotype 1	Narlaprevir Ritonavir Sofosbuvir	treatment	2	completed
NCT00606086	Safety and Efficacy of the Therapeutic Vaccine GI-5005 Combined With Pegylated Interferon Plus Ribavirin Standard of Care Therapy Versus Standard of Care Alone in Patients With Genotype 1 Chronic Hepatitis C Infection	GI-5005 Peginterferon alfa-2a Ribavirin	treatment	2	completed
NCT01241760	VX-950-C211 - A Dosing Regimen Study (Twice Daily Versus Every 8 Hours) of Telaprevir in Treatment-naïve Participants With Genotype 1 Chronic Hepatitis C Virus Infection	Peginterferon alfa-2a Ribavirin Telaprevir	treatment	3	completed
NCT01498068	Open-Label, Bridging Study of Telaprevir in Treatment-Naïve and Treatment-Experienced Russian Patients With Genotype 1 Chronic Hepatitis C	Interferon alfa Ribavirin Telaprevir	treatment	3	completed
NCT00882193	Pilot Study of Betaine + Combination Antiviral Therapy for Chronic Hepatitis C Genotype 1 Non-responder/Relapsers	Benzalkonium Betaine Peginterferon alfa-2a Ribavirin	treatment	0	terminated
NCT00863109	Quality of Life During Treatment of Chronic Hepatitis C (P05278/MK-4031-336)	Peginterferon alfa-2b Ribavirin	Not Available	Not Available	completed
NCT01194037	A Phase 1b/2a, Open-label,Randomized, Safety, Tolerability, Dose Finding, PK/PD, and Preliminary Efficacy Study of SC Hanferon™ in Combination With Ribavirin in Treatment-naïve Subjects With Genotype 1 Hepatitis C	Interferon alfa Peginterferon alfa-2a	treatment	1 / 2	completed
NCT01121731	A Phase I/II Clinical Trial With Interferon Alfa 5 in Treatment-Experienced Patients With Genotype-1 Chronic Hepatitis C	Interferon alfa-2b	treatment	1 / 2	completed
NCT01405027	Impact of Physician Directed Education on Patient Compliance With Hepatitis C Therapy	No drug interventions	treatment	4	completed
NCT02669940	Observational, Multi-Center Study of the Real World Evidence of the Effectiveness of Paritaprevir/r - Ombitasvir, ± Dasabuvir, ± Ribavirin in Patients With Chronic Hepatitis C in the Russian Federation	No drug interventions	Not Available	Not Available	completed