NCT06462222
Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid Tumors treatment 1 / 2 not_yet_recruiting NCT06399926
Efficacy and Safety of Intraventricule Pemetrexed Disodium Administered Via Ommaya Reservoir Not Available Not Available recruiting NCT06282874
Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal Metastases treatment 4 not_yet_recruiting NCT05805631
Intrathecal Pemetrexed for Leptomeningeal Metastasis in EGFR-Mutant NSCLC treatment 2 not_yet_recruiting NCT03082144
Concurrent Involved-field Radiotherapy and Intrathecal Chemotherapy for Leptomeningeal Metastases From Solid Tumors treatment 2 completed NCT05257967
CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease No drug interventions diagnostic Not Available recruiting NCT04944069
Almonertinib With Bevacizumab for EGFR-Mutant NSCLC Patients With Leptomeningeal Metastasis treatment Not Available not_yet_recruiting NCT04315246
177Lu-DTPA-Omburtamab Radioimmunotherapy for Leptomeningeal Metastasis From Solid Tumors (Breast, NSCLC, Malignant Melanoma) treatment 1 / 2 withdrawn NCT06417710
Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis No drug interventions Not Available Not Available recruiting NCT04425681
Osimertinib With Bevacizumab for Leptomeningeal Metastasis From EGFR-mutation Non-Small Cell Lung Cancer treatment 2 unknown_status NCT04192981
GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases treatment 1 active_not_recruiting NCT06230055
Intrathecal Chemotherapy Through Ommaya Reservoir Upon Her-2 Negative Breast Cancer With Leptomeningeal Metastasis No drug interventions treatment 4 recruiting NCT04233021
Study of Osimertinib in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation treatment 2 active_not_recruiting NCT05800275
Capecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients with Leptomeningeal Disease No drug interventions treatment 2 recruiting NCT05034497
Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases treatment 1 recruiting NCT02948751
Microfluidic Device to Diagnose Leptomeningeal Metastasis in Breast Cancer No drug interventions other Not Available completed NCT06441045
Double Dose of Third-generation EGFR-TKI Plus Intrathecal Pemetrexed Versus Double Dose of Third-generation EGFR-TKI in Patients With LM Progression Following the Treatment of Routine Dose of Third-generation EGFR-TKI treatment 2 not_yet_recruiting NCT06431685
Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer treatment 1 recruiting NCT06058988
Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer treatment 2 recruiting NCT04588545
Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease treatment 1 / 2 recruiting NCT05598853
Intrathecal Double Checkpoint Inhibition treatment 1 recruiting NCT04729348
Pembrolizumab And Lenvatinib In Leptomeningeal Metastases treatment 2 terminated NCT06304441
Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer treatment Not Available recruiting NCT06296745
Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib. treatment 2 not_yet_recruiting NCT05146219
Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation No drug interventions treatment 2 active_not_recruiting NCT05746754
Proton Cranio-spinal Irradiation for Leptomeningeal Metastasis No drug interventions treatment Not Available recruiting NCT05414123
A Therapy Treatment Response Trial in Patients With Leptomeningeal Metastases ((LM) Using CNSide No drug interventions Not Available Not Available terminated NCT04420598
DS-8201a for trEatment of aBc, BRain Mets, And Her2[+] Disease treatment 2 completed NCT05385185
Clinical Observation of ICI Combined With Recombinant Human Endostatin on Leptomeningeal Metastasis of Lung Cancer treatment 2 recruiting NCT05305885
Intra-pemetrexed Alone or Combined With Concurrent Radiotherapy for Leptomeningeal Metastasis treatment Not Available recruiting NCT04833205
Clinical Efficacy and Safety of EGFR-TKI Combined With Nimotuzumab in the Treatment of Leptomeningeal Metastases From Lung Cancer treatment 2 recruiting NCT04778800
A Dose Exploration Study of Almonertinib for EGFRm NSCLC Patients With Brain/Leptomeningeal Metastasis (ARTISTRY) treatment Not Available recruiting NCT04356222
Efficacy and Safety of Durvalumab in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis treatment 4 not_yet_recruiting NCT04356118
Efficacy and Safety of Recombinant Human Endostatin in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis treatment 4 not_yet_recruiting NCT04178343
Tomotherapy for Leptomeningeal Metastases No drug interventions treatment Not Available completed NCT04148898
Osimertinib With or Without Bevacizumab for EGFR- Mutant Non-small Cell Lung Cancer With Leptomeningeal Metastasis treatment 2 unknown_status NCT03974204
Analyses of Exosomes in the Cerebrospinal Fluid for Breast Cancer Patients With Suspicion of Leptomeningeal Metastasis. No drug interventions diagnostic Not Available withdrawn NCT03507244
Concurrent Intrathecal-pemetrexed and Involved-field Radiotherapy for Leptomeningeal Metastasis From Solid Tumors treatment 1 / 2 completed NCT02803619
A Multi-center Prospective Observational Biomarker Study on EGFRm+ Non-small Cell Lung Cancer Patients With Leptomeningeal Metastasis No drug interventions Not Available Not Available unknown_status NCT02071056
Circulating Tumor DNA in Cerebrospinal Fluid as an Early Biomarker of Leptomeningeal Metastasis (LM) No drug interventions Not Available Not Available completed NCT01281696
Bevacizumab With Etoposide and Cisplatin in Breast Cancer Patients With Brain and/or Leptomeningeal Metastasis treatment 2 completed NCT00924820
A Pilot Study of Bevacizumab for Neoplastic Meningitis treatment 1 / 2 completed NCT00964743
Depocyt® With Sorafenib in Neoplastic Meningitis treatment Not Available terminated NCT00674674
Phase 1 Intrathecal Topotecan for Neoplastic Meningitis supportive_care 1 completed NCT00523939
DepoCyt for Active Lymphomatous or Leukemic Meningitis treatment 2 terminated NCT00515788
DepoCyt Plus Temozolomide in Patients With Neoplastic Meningitis treatment 1 terminated NCT00512460
RTA 744 Injection in Patients With Leptomeningeal Disease treatment 1 terminated NCT01645839
Interest of Intrathecal Chemotherapy With Liposomal Cytarabine (DepoCyte®) in Meningeal Metastasis of Breast Cancer treatment 3 completed NCT04343573
Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors No drug interventions treatment 2 active_not_recruiting NCT06462092
Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast Cancer treatment 1 / 2 not_yet_recruiting NCT03613181
ANG1005 in Leptomeningeal Disease From Breast Cancer treatment 3 not_yet_recruiting NCT05289908
Intrathecal Pemetrexed for Leptomeningeal Metastasis treatment 1 / 2 active_not_recruiting NCT00992602
Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast Cancer treatment 2 completed NCT03101579
Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer treatment 1 completed NCT05184816
A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis treatment 1 recruiting NCT03275402
131I-omburtamab Radioimmunotherapy for Neuroblastoma Central Nervous System/Leptomeningeal Metastases treatment 2 / 3 terminated NCT03719768
Avelumab With Radiotherapy in Patients With Leptomeningeal Disease treatment 1 active_not_recruiting NCT03661424
BATs in Patients With Breast Cancer and Leptomeningeal Metastases No drug interventions treatment 1 terminated NCT03520504
Study of Proton Radiation to the Brain and Spinal Cord for Patients With Leptomeningeal Metastases No drug interventions treatment 1 completed NCT02616393
Phase 2 Study of Study of Tesevatinib in Subjects With NSCLC and Brain or Leptomeningeal Metastases treatment 2 completed NCT01438021
Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease treatment Not Available withdrawn NCT00005811
Topotecan Hydrochloride in Treating Children With Meningeal Cancer That Has Not Responded to Previous Treatment treatment 2 completed NCT00005812
Temozolomide in Treating Patients With Leptomeningeal Metastases From a Solid Tumor or Lymphoma treatment 2 terminated NCT01596127
Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System treatment 1 / 2 terminated NCT02684071
Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors treatment 2 terminated NCT05746325
Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast Cancer No drug interventions treatment Not Available recruiting NCT03696030
HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases No drug interventions treatment 1 recruiting NCT06500481
Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial No drug interventions treatment 3 not_yet_recruiting NCT06518057
Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer No drug interventions treatment 2 not_yet_recruiting NCT04460937
Testing the Addition of an Anti-cancer Drug, Adavosertib, to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction Cancers treatment 1 active_not_recruiting NCT06137651
Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis treatment 1 withdrawn NCT03423628
A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer No drug interventions treatment 1 recruiting NCT03711422
Afatinib on CNS Metastases and LMD in EGFR Mutation Positive NSCLC treatment 1 terminated NCT06146010
Non Interventional German Leptomeningeal Disease Register No drug interventions Not Available Not Available recruiting NCT03501979
Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD treatment 2 active_not_recruiting NCT05809752
A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV) No drug interventions treatment 1 recruiting NCT02422641
Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis treatment 2 recruiting NCT05112549
Intrathecal Application of PD1 Antibody in Metastatic Solid Tumors With Leptomeningeal Disease (IT-PD1/ NOA 26) treatment 1 recruiting NCT00527410
A Safety Study of RTA 744 in Recurrent, Progressive or Refractory Neoplastic Meningitis treatment 1 terminated NCT02939300
Ipilimumab and Nivolumab in Leptomeningeal Metastases treatment 2 completed NCT02755987
Expanded Access to ANG1005 for Individual Patients Not Available Not Available no_longer_available NCT00830245
A Study to Assess the Efficacy of Erlotinib for Leptomeningeal Carcinomatosis in EGFR Mutation Positive Non-small Cell Lung Cancer treatment 2 terminated