Premenstrual Dysphoric Disorder (PMDD) (DBCOND0065799)

Identifiers

Synonyms

Premenstrual Dysphoric Disorder / PMDD / Premenstrual dysmorphic disorder / Premenstrual dysphoric disorder (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Citalopram	A selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression.	Sodium-dependent serotonin transportertarget Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 1A2enzyme Histamine H1 receptortarget Amine oxidase [flavin-containing] Aenzyme Amine oxidase [flavin-containing] Benzyme Aldehyde oxidaseenzyme
Drospirenone	A progestin used in oral contraceptive pills for the prevention of pregnancy and other conditions.	Progesterone receptortarget Mineralocorticoid receptortarget Androgen receptortarget Prostaglandin G/H synthase 2enzyme Serum paraoxonase/arylesterase 1enzyme Glucocorticoid receptortarget Cytochrome P450 3A4enzyme
Ethinylestradiol	An estradiol used as a contraceptive.	Estrogen receptortarget Nuclear receptor subfamily 1 group I member 2target Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme Bile salt export pumptransporter Hepatic sodium/bile acid cotransportertransporter ATP-binding cassette sub-family C member 2transporter ATP-dependent translocase ABCB1transporter UDP-glucuronosyltransferase 1A1enzyme Cytochrome P450 2C19enzyme UDP-glucuronosyltransferase 1A4enzyme UDP-glucuronosyltransferase 1A9enzyme Cytochrome P450 2C9enzyme Cytochrome P450 1A2enzyme Sulfotransferase 1E1enzyme Sulfotransferase 1A3enzyme Cytochrome P450 3A5enzyme UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 1A3enzyme Catechol O-methyltransferaseenzyme Solute carrier organic anion transporter family member 1A2transporter Albumincarrier Sex hormone-binding globulincarrier
Fluoxetine	A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I.	Sodium-dependent serotonin transportertarget Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme CYP2B proteinenzyme Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2B6enzyme Cytochrome P450 3A5enzyme Albumincarrier Alpha-1-acid glycoprotein 1carrier Voltage-gated inwardly rectifying potassium channel KCNH2target 5-hydroxytryptamine receptor 2Ctarget Cyclin-dependent kinases regulatory subunit 1target Neuronal acetylcholine receptor subunit alpha-2target Neuronal acetylcholine receptor subunit alpha-3target Neuronal acetylcholine receptor subunit beta-4target
Paroxetine	A selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder.	Sodium-dependent serotonin transportertarget Sodium-dependent noradrenaline transportertarget 5-hydroxytryptamine receptor 2Atarget Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2B6enzyme Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Alpha-1 adrenergic receptorstarget Alpha-2 adrenergic receptorstarget Beta adrenergic receptortarget D(2) dopamine receptortarget Histamine H1 receptortarget Serotonin Receptorstarget Muscarinic acetylcholine receptortarget 5-hydroxytryptamine receptor 2Btarget D(1) dopamine receptortarget Cytochrome P450 2C19enzyme
Sertraline	A selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions.	Sodium-dependent serotonin transportertarget Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme Sodium-dependent dopamine transportertarget CYP2B proteinenzyme Cytochrome P450 3A4enzyme Amine oxidase [flavin-containing] Benzyme Amine oxidase [flavin-containing] Aenzyme ATP-dependent translocase ABCB1transporter Albumincarrier Sigma receptortarget Sodium-dependent noradrenaline transportertarget Equilibrative nucleoside transporter 4target Cytochrome P450 2E1enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06648382	Pilot Study of the 'Thriving With PMDs' Program	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT05098574	Oral Contraceptives for Treating Premenstrual Dysphoric Disorder in Bipolar Disorder	Drospirenone Ethinylestradiol	treatment	2	completed
NCT03449979	Single Session of tACS in a Depressive Episode	No drug interventions	basic_science	Not Available	completed
NCT00536198	Evaluating the Effectiveness of Sertraline in Treating Women With Premenstrual Dysphoric Disorder	Sertraline	treatment	4	completed
NCT04123483	EnBrace HR for PMS With Prominent Mood Symptoms or Menstrual Related Mood Disorders	1,2-Docosahexanoyl-sn-glycero-3-phosphoserine 1,2-icosapentoyl-sn-glycero-3-phosphoserine Betaine Cobamamide Cocarboxylase Ferrous cysteine glycinate Flavin adenine dinucleotide Folic acid L-threonic acid Leucovorin Levomefolic acid Magnesium ascorbate NADH Phosphatidyl serine Pyridoxal phosphate Zinc ascorbate	treatment	4	withdrawn
NCT01385709	The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels	No drug interventions	Not Available	Not Available	completed
NCT05327075	Premenstrual Dysphoric Disorder:Knowledge,Attitude and Practice Among Egyptian Females	No drug interventions	Not Available	Not Available	unknown_status
NCT00518570	Levetiracetam in the Treatment of Patients With Premenstrual Dysphoric Disorder (PMDD)	Levetiracetam	treatment	Not Available	completed
NCT02448836	Deep Transcranial Magnetic Stimulation (dTMS) for the Treatment of Premenstrual Dysphoric Disorder (PMDD)	No drug interventions	treatment	Not Available	unknown_status
NCT00516113	A Placebo-Controlled Study to Investigate the Onset of Action of Paroxetine in Premenstrual Dysphoria	Paroxetine	treatment	4	completed
NCT01875718	A Phase I/II Study to Evaluate UC1010 Treatment in Premenstrual Dysphoric Disorder (PMDD)	Sepranolone	treatment	1 / 2	completed
NCT06496139	Emotion Regulation-based Internet-delivered Cognitive Behavioural Therapy for Premenstrual Dysphoric Disorder	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT00678574	The Role of GABA and Neurosteroids in Premenstrual Dysphoric Disorder	Fluoxetine	treatment	4	completed
NCT06227676	Effect of 'Cramp Bites' on Period Cramps in Women Aged 18-25	No drug interventions	treatment	2 / 3	completed
NCT02362191	Targeting Inter-Hemispheric Alpha Coherence With tACS To Treat PMDD	No drug interventions	treatment	Not Available	terminated
NCT06136104	The Effects of Mixhers HERTIME Supplements on Menstrual Symptoms	No drug interventions	treatment	Not Available	completed
NCT00927095	Continuous Oral Contraceptive Treatment in Premenstrual Dysphoric Disorder (PMDD)	No drug interventions	treatment	4	completed
NCT02508103	Emotional Processing and Oxytocin Mechanisms in Premenstrual Dysphoric Disorder: A Pilot Study	Oxytocin	treatment	2 / 3	completed
NCT01799733	Alternative Treatments for Premenstrual Dysphoric Disorder	No drug interventions	treatment	Not Available	completed
NCT01217775	Intranasal PH80 Spray for Acute Management of the Symptoms of Premenstrual Dysphoric Disorder	No drug interventions	treatment	3	unknown_status
NCT05813366	Combined Effect of Tryptophan Rich Diet and Acupuncture on Depression Related to Premenstrual Dysphoric Disorder	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT03697265	A Study of Efficacy and Safety of Sepranolone (UC1010) in Patients With Premenstrual Dysphoric Disorder (PMDD)	Sepranolone	treatment	2	completed
NCT06462391	Adapting and Piloting Acceptance and Commitment Therapy (ACT) for Severe Premenstrual Mood Symptoms	No drug interventions	other	Not Available	not_yet_recruiting
NCT03862469	Premenstrual Hormonal and Affective State Evaluation (PHASE) Project	No drug interventions	prevention	Not Available	completed
NCT00620581	Luteal Phase Administration of Paroxetine for the Treatment of PMDD	Paroxetine	Not Available	3	completed
NCT00089414	Treatment of Menstrually Related Disorders With Continuous v. Interrupted Oral Contraceptives	Drospirenone Ethinylestradiol Progesterone Ulipristal	treatment	2	terminated
NCT06130371	Stress, Inflammation and Neuroimaging in Major Depressive Disorder as Compared to Premenstrual Dysphoric Disorder	No drug interventions	Not Available	Not Available	recruiting
NCT02777372	Stress & Premenstrual Symptoms Study	Sertraline	treatment	4	completed
NCT00824187	YAZ Premenstrual Dysphoric Disorder (PMDD) in China	Drospirenone	treatment	3	completed
NCT01945372	Neurofeedback Treatment of Affective Instability in Premenstrual Dysphoric Disorder(PMDD)	No drug interventions	treatment	Not Available	unknown_status