Advanced Non-Small Cell Lung Cancer (NSCLC) (DBCOND0067310)

Identifiers

Synonyms
Advanced Stage Non Small Cell Lung Cancer / Advanced Stage Non-small Cell Lung Cancer / Advanced NSCLC / Advanced Non-Small Cell Lung Cancer

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Carboplatin
A alkylating agent used to treat advanced ovarian cancer.
Hu-rhEGF-rP64k/Mont
A vaccine used to prevent recurrence of certain lung cancers in patients who have already received cyclophosphamide.
No drug targets
Lorlatinib
An anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer.
Trametinib
A kinase inhibitor used alone or in combination with dabrafenib to treat patients with cancers with specific BRAF mutations, such as melanoma and non-small cell lung cancer.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT01955421
Erlotinib 100mg qd Versus Gefitinib 250mg qd for EGFR Mutant Nsclctreatment2unknown_status
NCT05701176
A Clinical Imaging Study of the Changes in [18F]F-AraG Uptake Following Anti-PD-1 Therapy in Non-small Cell Lung CancerNo drug interventionsdiagnosticNot Availablerecruiting
NCT02350764
Evaluate the Mediators of Sensitivity and Resistance to Nivolumab Plus Ipilimumab in Patients With Advanced NSCLCstreatment2completed
NCT01101334
Study of Erlotinib With or Without Investigational Drug (CS-7017) in Subjects With Advanced Non-small Cell Lung Cancertreatment2completed
NCT01646125
An Open-label, Randomized Phase II Study to Evaluate the Efficacy of AUY922 vs Pemetrexed or Docetaxel in NSCLC Patients With EGFR Mutationstreatment2terminated
NCT04982224
Study of REGN5093-M114 (METxMET Antibody-Drug Conjugate) in Adult Patients With Mesenchymal Epithelial Transition Factor (MET) Overexpressing Advanced Cancertreatment1 / 2recruiting
NCT05609578
Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutationtreatment2recruiting
NCT06613633
Third-generation EGFR-TKI Treatment in Metastatic EGFR-mutant NSCLC: a Prospective, Observational StudyNot AvailableNot Availablecompleted
NCT06604689
AI-guided Prognostication and Cranial Radiotherapy Optimization in EGFR-TKI-treated Non-small Cell Lung Cancer Patients With Baseline Brain MetastasesNot AvailableNot Availablenot_yet_recruiting
NCT04229121
Clinical Sensitivity Verification Study of Circulating Tumor Cells Gene Mutation Detection From Advanced NSCLC PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT01211483
Study of Erlotinib With or Without Investigational Drug (U3-1287) in Subjects With Advanced Non-small Cell Lung Cancertreatment1 / 2completed
NCT00813332
Second-line Therapy Study of Combined Chemotherapy and Endostar to Patients With Non-Small Cell Lung Cancer(NSCLC)treatment4unknown_status
NCT06356675
A Single-arm Pilot Study of Tislelizumab Combined With Anlotinib in Patients With Advanced NSCLC With Driver-negative After Progression to Immunotherapytreatment4not_yet_recruiting
NCT02133196
T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancertreatment2recruiting
NCT04992858
Ningetinib in Advanced NSCLC Skipping Mutations With MET Exon 14 Skipping Mutationstreatment2not_yet_recruiting
NCT05219162
Real-World Study on Gene Profile in Patients With Advanced NSCLC Who Progressed on First-Line Osimertinib Therapy(GPS).No drug interventionsdiagnostic4completed
NCT03215810
Nivolumab and Tumor Infiltrating Lymphocytes (TIL) in Advanced Non-Small Cell Lung Cancertreatment1completed
NCT04043195
Nivolumab and Ipilimumab in Combination With Immunogenic Chemotherapy for Patients With Advanced NSCLCtreatment1 / 2active_not_recruiting
NCT02055508
POSITIVE - Study (Part III) HeidelbergNo drug interventionssupportive_careNot Availablecompleted
NCT03062800
Study of Thalidomide in Treatment of Advanced Nsclc (Dream-003)treatment2unknown_status
NCT03074175
Plasma miRNAs Predict Radiosensitivity of Different Fractionation Regimes in Palliative Radiotherapy for Advanced Non-small Cell Lung Cancer:Multicenter Controlled Study.(RadmiR-01)No drug interventionstreatmentNot Availablecompleted
NCT03127449
AST2818 in Advanced Non-Small Cell Lung Cancer With EGFR MutationstreatmentNot Availableunknown_status
NCT05859217
A Study of Combining Cabozantinib and Atezolizumab for Advanced/Metastatic NSCLC (Cabatezo-1)treatment2not_yet_recruiting
NCT05106335
A Study to Evaluate Camrelizumab Combined With Famitinib as Subsequent Therapy in Patients With Advanced NSCLCtreatment3terminated
NCT04613596
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7treatment2 / 3recruiting
NCT05099172
First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)No drug interventionstreatment1 / 2recruiting
NCT05557591
A Trial to Learn How the Cancer Vaccine BNT116 in Combination With Cemiplimab Works and How Safe the Combination is in Adults With Advanced Non-small Cell Lung Cancer (EMPOWERVAX Lung 1)treatment2recruiting
NCT05607550
Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) with Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)treatment3recruiting
NCT05676931
Study With Immunotherapy Combinations in Participants With Metastatic Non-Small Cell Lung Cancertreatment2recruiting
NCT05777603
Study of Aerosolized Antibiotics and Pembrolizumab in Advanced Non-small Cell Lung Cancertreatment1recruiting
NCT06269133
Evaluation of Cemiplimab in Combination With Platinum-Doublet Chemotherapy in First-Line (1L) Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) in Adult United States (US) PatientsNot AvailableNot Availableactive_not_recruiting
NCT06279728
Medical Access Program for Datopotamab Deruxtecan in NSCLC PatientsNot AvailableNot Availableavailable
NCT06406166
Lifei Xiaoji Wan in Treatment of Advanced NSCLCNo drug interventionstreatmentNot Availablerecruiting
NCT06452277
A Study to Learn More About How Well BAY 2927088 Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Human Epidermal Growth Factor Receptor 2 (HER2)treatment3recruiting
NCT03334864
Observational Cohort Study of Advanced Non-small Cell Lung Cancer (CAPTRA-LUNG)No drug interventionsNot AvailableNot Availablerecruiting
NCT04733521
A Phase 1/2 Study of SC-43 in Combination With Cisplatintreatment1 / 2unknown_status
NCT05904379
AK112 and AK104 With or Without Chemotherapy in Advanced Non-small Cell Lung Cancertreatment1 / 2recruiting
NCT04818333
A Study of SHR-A1811 in Subjects With Advanced Non-small Cell Lung CancerNo drug interventionstreatment1 / 2active_not_recruiting
NCT02200354
The Safety and Efficacy of Pemetrexed Rechallenge With Bevacizumabtreatment2terminated
NCT01551251
Tumor Associated Macrophage in Advanced Non-small Cell Lung CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT04032847
ATL001 in Patients With Advanced Unresectable or Metastatic NSCLCtreatment1 / 2recruiting
NCT00983047
Nimotuzumab Plus Docetaxel in Chemotherapy-Refractory/Resistant Patients With Advanced Non-Small-Cell Lung Cancertreatment2terminated
NCT03856697
Abivertinib Maleate Versus Geifitinib in Patients With Advanced Non-small Cell Lung Cancer With Sensitive EGFR Mutationtreatment3unknown_status
NCT03681483
RO5126766 for Patients With Advanced KRAS-Mutant Lung Cancertreatment1completed
NCT02157883
Study to Assess the Effect of Itraconazole (a CYP3A4 Inhibitor) on the Pharmacokinetics of AZD9291, in Patients With EGFR Positive Non-small Cell Lung Cancer. Patients Will be Chosen From Those Who Have Already Been Prescribed an EGFR TKI Medicine (Such as Iressa or Tarceva)other1completed
NCT05303493
Camu-Camu Prebiotic and Immune Checkpoint Inhibition in Patients With Non-small Cell Lung Cancer and MelanomaNo drug interventionstreatment1recruiting
NCT00783471
Docetaxel Intermittent-Erlotinib (Tarceva®) In Metastatic Non Small Cell Lung Cancer (NSCLC)treatment2terminated
NCT05504278
Efficacy and Safety of IBI351 in Combination With Sintilimab ± Chemotherapy in Advanced Non-squamous Non-small Cell Lung Cancer Subjects With KRAS G12C Mutationtreatment1recruiting
NCT06348888
A Study to Learn About How Itraconazole and Carbamazepine Affect the Level of BAY2927088 in the Blood When These Drugs Are Taken Together by Healthy Participantsother1completed
NCT03371485
AST-VAC2 Vaccine in Patients With Non-small Cell Lung CancerNo drug interventionstreatment1completed
NCT01802632
AZD9291 First Time In Patients Ascending Dose Studytreatment1 / 2completed
NCT03326752
Phase 1b DV281 With an Anti-PD-1 Inhibitor in NSCLCtreatment1completed
NCT00345059
The DISTAL-2 Study: Docetaxel Alone or in Combination in Second-line Treatment of Advanced Non Small-Cell Lung Cancertreatment3terminated
NCT04541706
Lorlatinib in ALK Inhibitor Treated Unresectable Advanced/Recurrent ALK-Positive Non Small Cell Lung Cancer Patients in Indiatreatment4completed
NCT00064636
Phase I Dose Escalation Study of VELCADE Plus Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer or Other Solid Tumorstreatment1terminated
NCT01631136
Strategies for Maintenance Therapies in Advanced Non Small Cell Lung Cancertreatment3completed
NCT02175017
ONO-4538 Study in Patients With Advanced Non-Small Cell Lung Cancertreatment2completed
NCT03948724
Impact of Therapeutic Patient Education on the Toxicity of Immune Checkpoint Inhibitors in OncologyNo drug interventionspreventionNot Availableactive_not_recruiting
NCT04922658
Surufatinib or Surufatinib Combined With Vinorelbine for Non-Small Cell Lung Cancertreatment2recruiting
NCT05287386
A Single-Arm Phase II Clinical Study of Pemigatinib in the Treatment of Advanced Non-Small Cell Lung Cancer Patients With FGFR Alterations Who Have Failed Standard Therapytreatment2recruiting
NCT06174857
Efficacy of Osimertinib in Patients With Lung CancerNo drug interventionsNot AvailableNot Availablerecruiting
NCT02143466
AZD9291 in Combination With Ascending Doses of Novel Therapeuticstreatment1active_not_recruiting
NCT04785365
Long-Term Follow-Up Study of Patients Receiving ATL001No drug interventionsother2terminated
NCT05435274
Phase 1/2 Study of HS-10376 in Patients With Non-Small Cell Lung CancerNo drug interventionstreatment1 / 2recruiting
NCT05489731
VIC-1911 Combined With Osimertinib for EGFR -Mutant Non-small Cell Lung Cancertreatment1recruiting
NCT00786331
Pemetrexed +/- Carboplatin as Second Line Treatment in NSCLCtreatment2unknown_status
NCT05364073
Study of Furmonertinib in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Activating, Including Uncommon, Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Mutationstreatment1active_not_recruiting
NCT02952729
Study of Antibody Drug Conjugate in Patients With Advanced Breast Cancer Expressing HER2No drug interventionstreatment1completed
NCT02964689
Binimetinib in Addition to Standard Chemotherapy in KRAS Mutated NSCLC.treatment1completed
NCT03727867
Efficacy of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Combined With Early Stereotactic Body Radiation Therapy to the Primary Tumor in Advanced Non-small Cell Lung Cancertreatment3unknown_status
NCT05978401
Safety, Tolerability, and Efficacy of GLS-012 and GLS-010 in Patients With Advanced Non-Small Cell Lung Cancertreatment1 / 2not_yet_recruiting
NCT04886401
Retrospective Observational Study on Prediction of Response to PD-1 Immunotherapy in Patients With NSCLCNo drug interventionsNot AvailableNot Availableunknown_status
NCT05652868
Clinical Study of Antibody-Drug Conjugate MYTX-011 in Subjects With Non-Small Cell Lung CancerNo drug interventionstreatment1recruiting
NCT00708812
Paclitaxel Plus Carboplatin With or Without Endostar in Patients With Advanced Non-small Cell Lung Cancertreatment2completed
NCT03516981
A Study of Biomarker-Directed, Pembrolizumab (MK-3475) Based Combination Therapy for Advanced Non-Small Cell Lung Cancer (MK-3475-495/KEYNOTE-495)treatment2active_not_recruiting
NCT06329895
A Study to Learn About How BAY2927088 Affects the Level of Dabigatran or Rosuvastatin in the Blood When These Drugs Are Taken Together in Healthy Participantsother1completed
NCT00319514
Weekly Versus 3-Weekly Docetaxel Plus Cisplatin for Advanced NSCLCtreatment2completed
NCT03452150
D-0316 First Time in Patients Ascending Dose Studytreatment1completed
NCT05380908
Brain Metabolic Network of PET in Patients With Advanced Non-Small Cell Lung CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT04144608
Toripalimab Combined With Double Platinum-based Chemotherapy for Initially Unresectable NSCLCtreatment2completed
NCT04755738
Almonertinib Plus Microwave Ablation in Advanced Non-small Cell Lung Cancertreatment2not_yet_recruiting
NCT04239443
Clinical Study of PD-1 Monoclonal Antibody SHR-1210 and Apatinib in Advanced NSCLC, Soft Tissue Sarcoma, and Uterine Cancertreatment2unknown_status
NCT06434103
Clinical Study of SHR-A1921 Combined With Adebrelimab and SHR-8068 With or Without Carboplatin in the Treatment of Advanced NSCLCtreatment1 / 2not_yet_recruiting
NCT05499390
AK112 in Advanced Non-Small Cell Lung Cancertreatment3active_not_recruiting
NCT02108964
A Phase I/II, Multicenter, Open-label Study of EGFRmut-TKI EGF816, Administered Orally in Adult Patients With EGFRmut Solid Malignanciestreatment1 / 2completed
NCT04455984
Multimodality Treatment Including Curative Resection of Advanced NSCLCNo drug interventionsNot AvailableNot Availableunknown_status
NCT00602433
Hormone Changes in Women With Stage IIIB or Stage IV Non-Small Cell Lung Cancer Receiving ErlotinibNo drug interventionsNot AvailableNot Availablecompleted
NCT02163733
Study to Determine the Effect of Food on the Blood Levels of AZD9291 Following Oral Dosing of a Tablet Formulation in Patients With Non-Small Cell Lung Cancerother1completed
NCT00651833
Phase 2 Study of S-1 in Combination With Cisplatin as 1st Line Therapy in Advanced Non-Small Cell Lung CancerNo drug interventionstreatment2completed
NCT04263051
Evaluation of UCPVax Plus Nivolumab as Second Line Therapy in Advanced Non Small Cell Lung Cancertreatment2active_not_recruiting
NCT01649947
Modulation of Autophagy in Patients With Advanced/Recurrent Non-small Cell Lung Cancer - Phase IItreatment2completed
NCT01240447
Immunotherapy With Racotumomab Versus Support Treatment in Advanced Non-small Cell Lung Cancer Patientstreatment2completed
NCT03693547
Clinical Study of Utidelone Injection in Patients With Advanced Non-small Cell Lung Cancer(NSCLC)treatment2completed
NCT00652561
Phase 2 Study of S-1 as 2nd Line Therapy in Advanced Non-Small Cell Lung CancerNo drug interventionstreatment2completed
NCT03351361
Nivolumab and Ipilimumab Versus Chimiotherapy in First Line Treatment in PS 2 or Elderly in Advanced NSCLC Patientstreatment3completed
NCT00874328
A Study of TS-1 Plus Irinotecan and Cisplatin (IP) for Patients With Stage IIIB/IV Non Small Cell Lung Cancer (NSCLC)treatment1 / 2unknown_status
NCT06360211
A Study to Learn About How BAY2927088 Affects the Level of Midazolam in the Blood When Both Drugs Are Taken Together in Healthy Participantsother1completed
NCT00161278
Pilot Study for the Determination of Tumor Response to Chemotherapy in Advanced NSCLC Through Gene Expression Profilingtreatment2terminated
NCT06585059
Clinical Trial of TQB2928 in Combination With a Third-Generation Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) in Patients With Advanced Non-Small Cell Lung Cancerstreatment1not_yet_recruiting
NCT00948675
Study of Participants With Advanced Non-Small Cell Lung Cancertreatment3completed
NCT05416775
Phase Ib/II Study of SHR-8068 Injection in the Treatment of Advanced Non-small Cell Lung Cancertreatment1 / 2recruiting
NCT06221475
A Study to Learn How BAY2927088 is Taken up and Handled by the Body in Healthy Male ParticipantsNo drug interventionsother1completed
NCT02038699
A First-in-man Phase I/II Study of Oral ONC201 in Patients With Advanced Cancertreatment1 / 2withdrawn
NCT00385606
Study of Rofecoxib and Prolonged Constant Infusion of Gemcitabine in the Polychemotherapy Treatment of Advanced NSCLCtreatment2 / 3completed
NCT00349219
TORCH: A Study of Tarceva or Chemotherapy for the Treatment of Advanced Non Small Cell Lung Cancertreatment3completed
NCT02639234
Vigil™ + Nivolumab in Advanced Non-Small Cell Lung Cancertreatment2withdrawn
NCT05910034
Envafolimab Plus Docetaxel In Combination With or Without Trilaciclib Versus Docetaxel in Advanced NSCLCtreatment2not_yet_recruiting
NCT05001724
KN046 Plus Lenvatinib in Subject With Advanced Non-Small Cell Lung Cancer in the Failure of Anti-PD-(L)1 Agenttreatment2 / 3terminated
NCT06378658
A Study to Learn About How Food and Esomeprazole Affect the Level of BAY2927088 in the Blood When Taken Together in Healthy Participantsother1completed
NCT04685135
Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutationtreatment3active_not_recruiting
NCT03117335
Recombinant Endostatin Combined With Vinorelbine and Cisplatin in Patients With Advanced Non-small Cell Lung Cancertreatment3completed
NCT04990063
Adoptive TKC Transfer Combined With Chemotherapy for Advanced Non-small Cell Lung Cancer (NSCLC)No drug interventionstreatment1unknown_status
NCT02582125
ONO-4538 Study in Patients With Advanced Non-Small Cell Lung Cancertreatment2completed
NCT03014648
Evaluating the Efficacy of Atezolizumab in Advanced Non-small Cell Lung Cancer (NSCLC)treatment2completed
NCT03652857
Apatinib Combined With Vinorelbine for Non-driver Gene Mutation Non-small Cell Lung Cancertreatment2completed
NCT04049474
Bronchoscopic Cryo-Immunotherapy of Lung CancerNo drug interventionstreatment0active_not_recruiting
NCT06107374
Imaging Advanced NSCLC Patients Undergoing PD-1/PD-L1 Directed Therapy Using [18F]-FARAGNo drug interventionsdiagnostic2not_yet_recruiting
NCT05004974
Sintilimab With Pemigatinib in Patients With PD-L1-positive and FGFR Mutated Advanced Non-small Cell Lung Cancertreatment2recruiting
NCT05420220
Study of KN046 in Subjects With Advanced Non-Small Cell Lung Cancertreatment2recruiting
NCT00072631
Erlotinib (Tarceva (Trademark), OSI-774) in Treating Patients With Advanced Non-Small Cell Lung Cancertreatment2completed
NCT06043973
Almonertinib Combined With Anlotinib as First-line Treatment for Advanced Non-small Cell Lung Cancetreatment3recruiting
NCT05318573
A Study to Evaluate Safety, Efficacy of FF-10832 in Combo With Pembrolizumab in Urothelial & Non-small Cell Lung Cancertreatment2recruiting
NCT02407327
Individualized Treatment of Patients With Advanced NSCLC: Potential Application for Circulating Tumor Cells (CTC) Molecular and Phenotypical ProfilingNo drug interventionsNot AvailableNot Availablecompleted
NCT00633789
Phase II Study of Brivanib (BMS-582664) to Treat Multiple Tumor Typestreatment2completed
NCT00737867
Vinorelbine/Gemcitabine Versus Vinorelbine/Carboplatin in Advanced Non-small Cell Lung Cancertreatment3completed
NCT05215067
A Phase II Trial of AK104 in Advanced Non-Small Cell Lung Cancertreatment2unknown_status
NCT05785767
A Study to Learn if a Combination of Fianlimab and Cemiplimab Versus Cemiplimab Alone is More Effective for Adult Participants With Advanced Non-Small Cell Lung Cancer (NSCLC)treatment2 / 3recruiting
NCT05482568
A Trial of Injectable SHR-A1811 in Combination With Pyrotinib or SHR-1316 in Subjects With Advanced Non-small Cell Lung Cancertreatment1 / 2recruiting
NCT00487669
Phase II Study of Combination of Paclitaxel Poliglumex and Alimta for Advanced Non-small Cell Lung Cancer (NSCLC)treatment2completed
NCT00330746
CALC-1 (Cetuximab in Advanced Lung Cancer): Study of 2 Methods of Combining Cetuximab and Gemcitabine in Patients With Advanced Non Small-cell Lung Cancertreatment2completed
NCT01980212
Tumor Relapsed Study of Serum Trxr Activity in Advanced Non-small Cell Lung CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT05192681
Tislelizumab as Cross-line Treatment for Advanced NSCLCtreatment2unknown_status
NCT04699123
The Study of NC318 Alone or in Combination With Pembrolizumab in Patients With Advanced Non-small Cell Lung Cancertreatment2recruiting