Refractory Chronic Cough (DBCOND0073745)

Identifiers

Synonyms

Chronic Refractory Cough / Chronic, refractory Cough / Refractory chronic cough / Refractory chronic cough (disorder) / Coughing / Cough / Coughing - function (qualifier value) / Cough (finding)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Gefapixant	A P2X3 receptor antagonist that reduces the cough reflex in patients with refractory or unexplained chronic cough.	P2X purinoceptor 3target ATP-dependent translocase ABCB1transporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter P2X purinoceptor 2target
Hydromorphone	An opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.	Mu-type opioid receptortarget Delta-type opioid receptortarget Kappa-type opioid receptortarget Cytochrome P450 2C9enzyme UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 2B7enzyme Albumincarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02993822	A Dose-ranging Study of Orvepitant in Patients With Chronic Refractory Cough	No drug interventions	treatment	2	completed
NCT05570981	A Comprehensive Evaluation of the Impact of ATP on Laryngeal Symptoms, Hypersensitivity and Function	No drug interventions	Not Available	Not Available	recruiting
NCT01703923	An Exploratory Study of FP01 Lozenges in Subjects With Chronic Refractory Cough	No drug interventions	treatment	2	completed
NCT03979638	A Dose Escalation Study of BLU-5937 in Unexplained or Refractory Chronic Cough	Camlipixant	treatment	2	terminated
NCT02349425	A Dose Escalation Study of Gefapixant (AF-219/MK-7264) in Refractory Chronic Cough (MK-7264-010)	Gefapixant	treatment	2	completed
NCT05599191	A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough	Camlipixant	treatment	3	recruiting
NCT05628740	Placebo-controlled, Single and Multiple Dose Study in Healthy Volunteers and Refractory Chronic Cough Patients to Assess the Safety, Tolerability, and Pharmacokinetics of Two Formulations of NTX-1175	No drug interventions	treatment	1	completed
NCT05962151	Refractory Chronic Cough Improvement Via NAL ER (RIVER)	Nalbuphine	treatment	2	recruiting
NCT05110144	Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough	Amitriptyline Duloxetine	treatment	2	recruiting
NCT05600777	A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough (CALM-2)	Camlipixant	treatment	3	recruiting
NCT06213363	A Phase Ib/II Clinical Study in Patients With Refractory Chronic Cough	No drug interventions	treatment	1 / 2	not_yet_recruiting
NCT05733533	A Study to Assess the Efficacy and Tolerance of HRS-2261 in Subjects With Refractory Chronic Cough	No drug interventions	treatment	2	enrolling_by_invitation
NCT05265871	ATP Level and Cough Sensitivity to ATP in Subjects With Refractory Chronic Cough	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT04882943	COllaboration REsearch on Chronic Cough (COREC): a French Multicenter Database	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT04678206	Evaluation of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough	Camlipixant	treatment	2	completed
NCT03662269	Indomethacin for Refractory Chronic Cough	Indomethacin Omeprazole	treatment	3	unknown_status
NCT03282591	Study of the Efficacy, Safety, and Tolerability of Serlopitant for the Treatment of Refractory Chronic Cough	Serlopitant	treatment	2	completed
NCT02612610	A 12-Week Study in Participants With Refractory Chronic Cough (MK-7264-012)	Gefapixant	treatment	2	completed
NCT02612623	An 8-Week Refractory Chronic Cough Study (MK-7264-021)	Gefapixant	treatment	2	completed
NCT02476890	Effect of Gefapixant (MK-7264/AF-219) on Cough Reflex Sensitivity in Healthy and Chronic Cough Participants (MK-7264-014)	Gefapixant	treatment	2	completed
NCT02412020	Treatment of Refractory Chronic Cough With PA101	No drug interventions	treatment	2	completed
NCT02397460	Effect of Gefapixant (AF-219/MK-7264) on Cough Reflex Sensitivity (MK-7264-015)	Gefapixant	treatment	2	completed
NCT03407014	Effect of Gefapixant (MK-7264/AF-219) on Cough Reflex Sensitivity in Healthy and Chronic Cough Participants (MK-7264-014)	Gefapixant	treatment	2	completed