Hydromorphone is an opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated. Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of morphine that has been available clinically since 1920.
- Mechanism
- Curator reviewed · 4 references
Hydromorphone is an opioid agonist that can bind to different types of opioid receptors. Its analgesic effect is suggested to be related to the effect on the mu-opioid receptors. It has been reported to also have a minor affinity for the delta and kappa receptor. On the other hand, it is known to act at the level of the medulla which allows it to depress the respiratory drive and suppress cough.
The onset of action of the immediate release form of hydromorphone is achieved in 15-20 minutes and having a lasting effect for 3-4 hours while the extended-release form onset of action is of 6 hours lasting for about 13 hours.
- Primary indication
- Hydromorphone is indicated for the management of moderate to severe acute pain and severe chronic pain.Curator reviewed · 3 structured indications
- Formula / weight
- C17H19NO3 · 285.3377 g/mol (avg)
- First approval
- Canada, 2000 · United States, 1926
- Also known as
- 7,8-Dihydromorphinone · Dihydromorphinone · Dimorphone
- Code names
- IDS-NH-004 · N02AA03 · NSC-19046
- Brand names
Resolves to
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Which drugs share a target with Hydromorphone, and which of those have an active Phase 3 trial?
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