Hypertensive Emergency (DBCOND0078508)

Identifiers

Synonyms

Hypertensive emergency / Hypertensive emergency (disorder) / Hypertensive Crisis / Hypertensive crisis (disorder) / Crisis hypertensive

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Labetalol	An alpha and beta adrenergic antagonist used to treat hypertension, angina, and sympathetic overactivity syndrome.	Alpha-1 adrenergic receptorstarget Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 2C19enzyme Albumincarrier alpha1-acid glycoproteincarrier ATP-binding cassette sub-family B member 5transporter UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 1A9enzyme
Nifedipine	A dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension.	Cytochrome P450 3A4enzyme Cytochrome P450 2E1enzyme Cytochrome P450 2D6enzyme Voltage-dependent L-type calcium channel subunit alpha-1Dtarget Voltage-dependent L-type calcium channel subunit alpha-1Starget Voltage-dependent L-type calcium channel subunit alpha-1Ctarget Voltage-dependent L-type calcium channel subunit beta-2target A-type voltage-gated potassium channel KCND3target Voltage-dependent T-type calcium channeltarget Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2C8enzyme ATP-binding cassette sub-family C member 3transporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Cytochrome P450 1A1enzyme Cytochrome P450 2B6enzyme Nuclear receptor subfamily 1 group I member 2target Solute carrier organic anion transporter family member 1B1transporter Bile salt export pumptransporter Cytochrome P450 2C9enzyme Albumincarrier alpha1-acid glycoproteincarrier Cytochrome P450 3A5enzyme Calmodulintarget
Urapidil	A combination adrenergic antagonist and serotonin agonist given orally for the treatment of essential hypertension and intravenously in hypertensive emergencies.	5-hydroxytryptamine receptor 1Atarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06286696	Optic Nerve Sheath Diameter in Hypertensive Emergency	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT05155202	Clinical Relevance of Nicardipine Induced Hypoxemia in the Intensive Care Unit	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT04553653	Improving Acute Hypertension Management Through Emergency Department Checklist	No drug interventions	treatment	Not Available	completed
NCT04670809	Safety and Efficacy Study of Clevidipine Butyrate Injection in Hypertensive Emergencies	Clevidipine	treatment	3	unknown_status
NCT05922436	a Study Evaluating the Safety and Efficacy of Clevidipine for Patients Who With Hypertensive Emergency and Sub-emergency	Aloe vera leaf Clevidipine Coconut oil Hyaluronic acid Propylene glycol Rosemary	treatment	3	not_yet_recruiting
NCT05044364	Clinical Study of Clevidipine Butyrate Injection in the Treatment of Hypertensive Emergency and Sub-emergency	Clevidipine	treatment	3	unknown_status
NCT02672787	A ED-based Intervention to Improve Antihypertensive Adherence	No drug interventions	treatment	Not Available	completed
NCT02924805	Telemedical Versus Conventional Emergency Care of Hypertensive Emergencies	No drug interventions	Not Available	Not Available	completed
NCT05783557	A Study of Clevidipine Butyrate Injectable Emulsion in the Treatment of Hypertensive Emergency and Sub-emergency	Aloe vera leaf Clevidipine Coconut oil Hyaluronic acid Propylene glycol Rosemary	treatment	3	not_yet_recruiting
NCT06201572	The Value of TOI in Evaluating Renal Function Damage in Hypertensive Emergency Patients	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT05139238	Postpartum Hypertension Study	Labetalol Nifedipine	treatment	4	not_yet_recruiting