Clostridium Difficile Associated Diarrhea (CDAD) (DBCOND0085319)

Identifiers

Synonyms

C. difficile-associated diarrhea / C. difficile associated diarrhea / C. difficile associated diarrhea (CDAD) / Diarrhea caused by clostridium difficile / Diarrhea, Clostridium difficile / Diarrhea-Clostridium difficile / Clostridium Difficile Associated Diarrhea / Clostridium Difficile-Associated Diarrhea / Diarrhoea, Clostridium Difficile / Diarrhea (Clostridium difficile) / Clostridium Difficile-Associated Diarrhea (CDAD) / Clostridium Difficile Diarrhea / Clostridium difficile diarrhoea / Diarrhoea, Clostridioides difficile / Diarrhea, Clostridioides difficile / C.difficile diarrhea / C.difficile diarrhoea / Clostridium difficile diarrhea (disorder) / Clostridioides difficile colitis / Clostridioides enterocolitis / Clostridium difficile colitis (disorder) / Clostridium difficile colitis / C.difficile colitis

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Fidaxomicin	A macrolide antibiotic used to treat diarrhea associated with Clostridium difficile infection.	ATP-dependent translocase ABCB1transporter RNA polymerase sigma factor SigAtarget Cytochrome P450 3A4enzyme
Vancomycin	A glycopeptide antibiotic used to treat severe but susceptible bacterial infections such as MRSA (methicillin-resistant Staphylococcus aureus) infections.	D-Ala-D-Ala moiety of NAM/NAG peptide subunits of peptidoglycantarget Albumincarrier alpha1-acid glycoproteincarrier Histamine H1 receptorcarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03647995	Probiotics in the Prevention of Antibiotic Induced Diarrhea and Clostridium Difficile Associated Diarrhea.	No drug interventions	prevention	Not Available	terminated
NCT01591863	Safety, Tolerability, and Pharmacokinetics of Fidaxomicin in Pediatric Subjects With Clostridium Difficile-associated Diarrhea (CDAD)	Fidaxomicin	treatment	2	completed
NCT00747071	Safety and Validation of Efficacy of Oral Administration of the Food Additive Colostrum Derived Anti Clostridium Difficile Antibodies	Human colostrum	prevention	2 / 3	withdrawn
NCT01596153	Probiotics in Hospitalized Patients Study	No drug interventions	Not Available	Not Available	withdrawn
NCT01559545	A Safety, Tolerability and Pharmacokinetic Study of Two Formulations of Metronidazole Versus Immediate Release Metronidazole in Patient With C. Difficile Colitis	Metronidazole	treatment	2	completed
NCT00958308	Efficacy and Safety Study in the Prevention of Antibiotic-Associated Diarrhea (AAD) and Clostridium Difficile-Associated Diarrhea (CDAD) in Hospitalized Adult Patients Exposed to Nosocomial Infection	No drug interventions	prevention	3	completed
NCT00034294	A Study of GT160-246 Versus Vancomycin in Patients With Clostridium Difficile-Associated Diarrhea	No drug interventions	treatment	2	completed
NCT01570634	Proof-of-Concept, Calcium Aluminosilicate Anti-Diarrheal (CASAD) for Treatment of Clostridium Difficile Infection	Loperamide	treatment	2	terminated
NCT02835105	A Study of Ascending Single Doses of Surotomycin in Healthy Participants (MK-4261-008)	Surotomycin	treatment	1	completed
NCT02835118	A Study of Ascending Multiple Doses of Oral Surotomycin in Healthy Participants (MK-4261-009)	Surotomycin	treatment	1	completed
NCT00177970	IVIG Versus Placebo for the Treatment of Patients With Severe C-Diff	Human immunoglobulin G	treatment	4	terminated
NCT01691248	Safety and Efficacy of Fidaxomicin Versus Placebo for Prophylaxis Against Clostridium Difficile-Associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation (MK-5119-001)	Fidaxomicin	prevention	3	completed
NCT02218372	A Study to Investigate the Safety and Efficacy of Fidaxomicin (Oral Suspension or Tablets) and Vancomycin (Oral Liquid or Capsules) in Pediatric Subjects With Clostridium Difficile-associated Diarrhea (CDAD)	Fidaxomicin Salicylic acid Vancomycin	treatment	3	completed
NCT03806803	Multicentre Blinded Comparison of Lyophilized Sterile Fecal Filtrate to Lyophilized Fecal Microbiota Transplant in Recurrent Clostridioides Difficile Infection	Fecal microbiota	treatment	2	completed
NCT04246151	Oral Vancomycin Versus Probiotics Versus Placebo for Prevention of Clostridium Difficile Infection in Colonized Patients	Vancomycin	prevention	0	recruiting
NCT03141775	Incidence and Economic Burden of Clostridium Difficile Infections (CDI) in the German Health Care System (IBIS)	No drug interventions	Not Available	Not Available	unknown_status
NCT03793686	A Study of Safety of PBCLN-003 Following Antibiotic Therapy in Subjects With C.Difficile-associated Diarrhea	No drug interventions	treatment	1	terminated
NCT04305769	Alanyl-glutamine Supplementation for C. Difficile Treatment (ACT)	Alanyl glutamine L-Glutamine	treatment	2	recruiting
NCT00772954	Phase I Randomized, Placebo-Controlled, Double-Blind, Dose Ranging Study, Safety, Tolerability and Immunogenicity	No drug interventions	treatment	1	terminated
NCT02200328	Efficacy of Metronidazole Prophylaxis Against Clostridium Difficile-Associated Diarrhea in High Risk Adult Patients	Metronidazole Starch, corn	prevention	4	terminated
NCT00382304	A Study of the Absorption of GT267-004 in Patients With Clostridium Difficile-Associated Diarrhea	Tolevamer	treatment	2	completed