Locally Advanced Solid Neoplasm (DBCOND0091517)

Identifiers

Synonyms
Locally Advanced Solid Tumor / Locally Advanced Solid Tumors

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Repotrectinib
A tyrosine kinase inhibitor used to treat locally active or metastatic non-small cell lung cancer
Selpercatinib
A RET receptor tyrosine kinase inhibitor for the treatment of RET-driven non-small cell lung cancer, medullary thyroid cancer, and thyroid cancer in appropriate patient populations.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04094610
A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterationstreatment1 / 2recruiting
NCT06031441
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7566802 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumorstreatment1recruiting
NCT02045602
Phase I Dose Escalation Study of Intravenous VCN-01 With or Without Gemcitabine and Abraxane® in Patients With Advanced Solid Tumorstreatment1completed
NCT03093116
A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangementstreatment1 / 2recruiting
NCT03427320
Imaging of Advanced Tumours Using [131]I-IAZANo drug interventionsother1 / 2withdrawn
NCT03646071
A Study of RX108 in Patients With Locally Advanced or Metastatic Solid TumorsNo drug interventionstreatment1unknown_status
NCT03573544
This Study is to Evaluate Safe and Effective Treatment Dose of OBI-888 in Patients With Locally Advanced or Metastatic Solid Tumors.treatment1 / 2terminated
NCT02097810
Study of Oral RXDX-101 in Adult Patients With Locally Advanced or Metastatic Cancer Targeting NTRK1, NTRK2, NTRK3, ROS1, or ALK Molecular Alterations.treatment1completed
NCT03059823
A Phase 1 Study of INCMGA00012 in Patients With Advanced Solid Tumorstreatment1completed
NCT06658353
Phase III Clinical Study of VC004 in Patients With Localized Advanced/ Metastatic Solid TumorsNo drug interventionstreatment3not_yet_recruiting
NCT04799054
A Study of TransCon TLR7/8 Agonist With or Without Pembrolizumab in Patients With Advanced or Metastatic Solid Tumorstreatment1 / 2active_not_recruiting
NCT04975958
Double/Triple Combinations of AN2025, AN0025 and Atezolizumab in Advanced Solid Tumorstreatment1active_not_recruiting
NCT05732831
Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid TumorsNo drug interventionstreatment1 / 2recruiting
NCT06521554
A Study of NVL-330 in Patients With Advanced or Metastatic HER2-altered NSCLC (HEROEX-1)No drug interventionstreatment1recruiting
NCT04084366
Phase 1/2 Study of OBI-999 in Patients with Advanced Solid Tumorstreatment1 / 2terminated
NCT05081609
A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or TransCon TLR7/8 Agonist or Other Anticancer Therapies in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignanciestreatment1 / 2recruiting
NCT05731271
A First-in-Human, Phase 1 Study of TST003 in Subjects With Solid TumorsNo drug interventionstreatment1 / 2active_not_recruiting
NCT06630247
A Dose-escalation, Dose-finding, and Expansion Study of XL495 in Participants With Locally Advanced or Metastatic Solid TumorsNo drug interventionstreatment1recruiting
NCT05275478
Safety and Tolerability of TNG908 in Patients With MTAP-deleted Solid Tumorstreatment1 / 2recruiting
NCT05169437
Niraparib in the Treatment of Patients with Advanced PALB2 Mutated Tumorstreatment2terminated
NCT04260802
A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancerstreatment1 / 2recruiting
NCT05828277
A Phase 1 Study to Assess the Effect of Hepatic Impairment on the Pharmacokinetics of Repotrectinib in Advanced Cancer Patientstreatment1withdrawn
NCT03881488
Study of CTX-471 as a Monotherapy or in Combination With Pembrolizumab in Patients Post PD-1/PD-L1 Inhibitors in Metastatic or Locally Advanced Malignanciestreatment1active_not_recruiting
NCT06416007
Lattice Radiotherapy for Dose-Escalated Palliation of Bulky TumorsNo drug interventionstreatment2recruiting
NCT05919537
Study of an Anti-HER3 Antibody, HMBD-001, With or Without Chemotherapy in Patients With Solid Tumors Harboring an NRG1 Fusion or HER3 Mutationtreatment1recruiting
NCT05769075
A Study of TY-2136b in Patients With Advanced Solid Tumors Harboring ALK, ROS1 or NTRK1-3 AlterationsNo drug interventionstreatment1recruiting
NCT01390818
Trial of MEK Inhibitor and PI3K/mTOR Inhibitor in Subjects With Locally Advanced or Metastatic Solid Tumorstreatment1completed
NCT04914117
A Study of RC118 in Patients With Locally Advanced Unresectable/Metastatic Solid Tumourstreatment1completed
NCT06184035
A Dose Escalation and Expansion Study of [177Lu]Lu-SN201 in Participants With Advanced Cancertreatment1 / 2recruiting
NCT05378425
A Study of NTX-1088, a Monoclonal Antibody Targeting the Poliovirus Receptor (PVR, CD155), as Monotherapy and Combined With Pembrolizumabtreatment1recruiting
NCT04250948
Efficacy of Perioperative Chemotherapy Plus PD-1 Antibody in the Locally Advanced Gastric Cancertreatment2active_not_recruiting
NCT05384626
A Study of NVL-655 in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)treatment1 / 2recruiting
NCT05268666
A Study of Orally Administered JBI-802, an LSD1/HDAC6 Inhibitor, in Patients With Advanced Solid Tumorstreatment1 / 2recruiting
NCT05118789
A Study of NVL-520 in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)No drug interventionstreatment1 / 2recruiting
NCT05002140
Trial of XRD-0394, a Kinase Inhibitor, in Combination With Palliative Radiotherapy in Advanced Cancer PatientsNo drug interventionstreatment1completed
NCT04614740
The Phase I/Phase II Clinical Study of VC004 in Patients With Localized Advanced/Metastatic Solid TumorsNo drug interventionstreatment1 / 2recruiting
NCT04814667
A Retro-/Prospective, Non-interventional, Cohort Study in Adult Patients With Locally Advanced or Metastatic Tumors With a Neurotrophic Tyrosine Receptor Kinase (NTRK) Gene Fusion, Treated With LarotrectinibNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04383210
Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumorstreatment2active_not_recruiting
NCT06349408
IBI3001 in Participants With Unresectable, Locally Advanced or Metastatic Solid TumorsNo drug interventionstreatment1 / 2not_yet_recruiting
NCT06534190
CD8 PET Imaging in Metastatic Solid Tumourstreatment2not_yet_recruiting
NCT05919264
FOG-001 in Locally Advanced or Metastatic Solid TumorsNo drug interventionstreatment1 / 2recruiting
NCT03284502
HM95573 in Combination With Either Cobimetinib or Cetuximab in Patients With Locally Advanced or Metastatic Solid Tumorstreatment1active_not_recruiting
NCT06415487
ACE2016 in Adult Subjects With Locally Advanced or Metastatic Solid Tumors Expressing Epidermal Growth Factor Receptor (EGFR)treatment1not_yet_recruiting
NCT05028478
A Study of CN202 in Adult Subjects With Locally Advanced or Metastatic Solid Tumors or Hematologic MalignanciesNo drug interventionstreatment1 / 2unknown_status
NCT04770688
Advanced Lung Tumor Treated by Osimertinib Plus Anlotinibtreatment1 / 2completed
NCT04050709
QUILT-3.064: PD-L1 t-haNK In Subjects With Locally Advanced Or Metastatic Solid Cancerstreatment1active_not_recruiting
NCT06028724
A Study on the Prevalence of Clinically Useful Mutations in Solid Tumor Characterized by Next Generation Sequencing Methods on Liquid Biopsy Analysis (POPCORN)No drug interventionsNot AvailableNot Availablerecruiting
NCT04200963
A Phase 1a/b Study of IK-175 as a Single Agent and in Combination With Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumors and Urothelial Carcinomatreatment1completed
NCT05717348
A Study of ES014 in Patients With Locally Advanced or Metastatic Solid TumoursNo drug interventionstreatment1recruiting
NCT05218148
SOX Combined With Sintilimab and Trastuzumab Versus SOX Regimen in the Perioperative Treatment of HER2-positive Locally Advanced Gastric Adenocarcinomatreatment2not_yet_recruiting
NCT04319757
ACE1702 in Subjects With Advanced or Metastatic HER2-expressing Solid Tumorstreatment1recruiting
NCT03428802
Pembrolizumab in Treating Participants With Metastatic, Recurrent or Locally Advanced Cancer and Genomic Instabilitytreatment2recruiting
NCT03590054
Abexinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumor Malignanciestreatment1completed