carcinoid syndrome diarrhea (DBCOND0091915)
Identifiers
- Synonyms
- Diarrhea co-occurrent and due to carcinoid syndrome (disorder)
Associated Data
- Indicated Drugs and Targets
Drug Description Targets Telotristat ethyl A tryptophan hydroxylase inhibitor that is used to treat carcinoid syndrome diarrhea.- Tryptophan 5-hydroxylase 2target
- Tryptophan 5-hydroxylase 1target
- ATP-dependent translocase ABCB1transporter
- Cytochrome P450 3A4enzyme
- Cytochrome P450 2B6enzyme
- Liver carboxylesterase 1enzyme
- Broad substrate specificity ATP-binding cassette transporter ABCG2carrier
- Cocaine esteraseenzyme
- UDP-glucuronosyltransferase 2B4enzyme
- UDP-glucuronosyltransferase 2B7enzyme
- Cytochrome P450 2C9enzyme
- Cytochrome P450 2C19enzyme
- Cytochrome P450 2D6enzyme
- Cytochrome P450 2C8enzyme
- Clinical Trials
Identifier Title Drug(s) Purpose Phase Status NCT05361668 Study to Evaluate the Safety, PK, and Dose Response of Paltusotine in Subjects With Carcinoid Syndrome treatment 2 active_not_recruiting