Severe restless legs syndrome (RLS) (DBCOND0118936)

Identifiers

Synonyms

Severe restless leg syndrome / Severe Restless Legs Syndrome / Severe Restless Legs Syndrome (RLS)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Pramipexole	A non-ergot dopamine agonist used to treat the signs and symptoms of idiopathic Parkinson's disease and Restless Legs Syndrome (RLS).	D(3) dopamine receptortarget D(4) dopamine receptortarget D(2) dopamine receptortarget 5-hydroxytryptamine receptor 1Atarget Alpha-2A adrenergic receptortarget Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Solute carrier family 22 member 3transporter
Ropinirole	A non-ergoline dopamine agonist used to treat the symptoms of Parkinson's disease and Restless Legs Syndrome.	D(2) dopamine receptortarget D(3) dopamine receptortarget D(4) dopamine receptortarget Cytochrome P450 1A2enzyme Alpha adrenergic receptortarget
Rotigotine	A non-selective dopamine agonist used for the treatment of Parkinson's Disease and Restless Leg Syndrome.	D(3) dopamine receptortarget D(1B) dopamine receptortarget D(4) dopamine receptortarget D(2) dopamine receptortarget 5-hydroxytryptamine receptor 1Atarget D(1A) dopamine receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Alpha-2B adrenergic receptortarget Cytochrome P450 2C19enzyme

Clinical Trials

Not Available