Metastatic Gastrointestinal Stromal Tumors (GIST) (DBCOND0164043)

Identifiers

Synonyms

Metastatic Gastrointestinal Stromal Tumor / Metastatic Gastrointestinal Stromal Tumor (GIST)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Avapritinib	A selective tyrosine kinase inhibitor being investigated for the treatment of multidrug resistant gastrointestinal tumors.	Mast/stem cell growth factor receptor Kittarget ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 3A4enzyme Cytochrome P450 2C9enzyme Bile salt export pumptransporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Platelet-derived growth factor receptor alphatarget
Imatinib	A tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.	Platelet-derived growth factor receptor betatarget Tyrosine-protein kinase ABL1target Mast/stem cell growth factor receptor Kittarget Proto-oncogene tyrosine-protein kinase receptor Rettarget High affinity nerve growth factor receptortarget Macrophage colony-stimulating factor 1 receptortarget Platelet-derived growth factor receptor alphatarget Epithelial discoidin domain-containing receptor 1target Cytochrome P450 3A4enzyme Breakpoint cluster region proteintarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 1transporter ATP-dependent translocase ABCB1transporter Solute carrier family 22 member 2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Phospholipid-transporting ATPase ABCA3transporter Albumincarrier Alpha-1-acid glycoprotein 1carrier Bile salt export pumptransporter Cytochrome P450 2C8enzyme ATP-binding cassette sub-family C member 2transporter Multidrug resistance-associated protein 1transporter Organic cation/carnitine transporter 2transporter Solute carrier organic anion transporter family member 1B3transporter ATP-binding cassette sub-family C member 4transporter Solute carrier organic anion transporter family member 1A2transporter Discoidin domain-containing receptor 2target Induced myeloid leukemia cell differentiation protein Mcl-1target
Regorafenib	A kinase inhibitor used to treat patients with metastatic colorectal cancer, unresectable, locally advanced, or metastatic gastrointestinal stromal tumors, and hepatocellular carcinoma.	Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 1A9enzyme Proto-oncogene tyrosine-protein kinase receptor Rettarget Vascular endothelial growth factor receptor 1target Vascular endothelial growth factor receptor 2target Vascular endothelial growth factor receptor 3target Mast/stem cell growth factor receptor Kittarget Platelet-derived growth factor receptor alphatarget Platelet-derived growth factor receptor betatarget Fibroblast growth factor receptor 1target Fibroblast growth factor receptor 2target Angiopoietin-1 receptortarget Discoidin domain-containing receptor 2target High affinity nerve growth factor receptortarget Ephrin type-A receptor 2target RAF proto-oncogene serine/threonine-protein kinasetarget Serine/threonine-protein kinase B-raftarget Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2B6enzyme Mitogen-activated protein kinase 11target Tyrosine-protein kinase FRKtarget Tyrosine-protein kinase ABL1target ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter UDP-glucuronosyltransferase 1A1enzyme Cytochrome P450 2C19enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04595747	Testing the Anti-cancer Drug, Rogaratinib (BAY 1163877), for Treatment of Advanced Sarcoma With Alteration in Fibroblast Growth Factor Receptor (FGFR 1-4), and in Patients With SDH-deficient Gastrointestinal Stromal Tumor (GIST)	Rogaratinib	treatment	2	active_not_recruiting
NCT01738139	Ipilimumab and Imatinib Mesylate in Advanced Cancer	Imatinib Ipilimumab	treatment	1	completed
NCT02216578	Ph II CABOGIST in GIST	Cabozantinib	treatment	2	completed
NCT05152472	A Prospective, Randomized, Multicenter, Comparative Study of the Efficacy of Imatinib Resumption Combined With Atezolizumab Versus Imatinib Resumption Alone in Patients With Unresectable Advanced Gastrointestinal Stromal Tumors (GIST) After Failure of Standard Treatments	Atezolizumab Imatinib	treatment	2	recruiting
NCT05009927	Efficiency of Imatinib Treatment After 10 Years of Treatment in Patients With Gastrointestinal Stromal Tumours (GIST) (Gist-Ten)	Imatinib	treatment	2	recruiting
NCT01735955	Study to Allow Access to Nilotinib for Patients Who Are on Nilotinib Treatment in a Novartis-sponsored Study	Nilotinib	treatment	4	completed