Metastatic Gastrointestinal Stromal Tumors (GIST) (DBCOND0164043)

Identifiers

Synonyms
Metastatic Gastrointestinal Stromal Tumor / Metastatic Gastrointestinal Stromal Tumor (GIST)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Avapritinib
A selective tyrosine kinase inhibitor being investigated for the treatment of multidrug resistant gastrointestinal tumors.
Imatinib
A tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.
Regorafenib
A kinase inhibitor used to treat patients with metastatic colorectal cancer, unresectable, locally advanced, or metastatic gastrointestinal stromal tumors, and hepatocellular carcinoma.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04595747
Testing the Anti-cancer Drug, Rogaratinib (BAY 1163877), for Treatment of Advanced Sarcoma With Alteration in Fibroblast Growth Factor Receptor (FGFR 1-4), and in Patients With SDH-deficient Gastrointestinal Stromal Tumor (GIST)treatment2active_not_recruiting
NCT01738139
Ipilimumab and Imatinib Mesylate in Advanced Cancertreatment1completed
NCT02216578
Ph II CABOGIST in GISTtreatment2completed
NCT05152472
A Prospective, Randomized, Multicenter, Comparative Study of the Efficacy of Imatinib Resumption Combined With Atezolizumab Versus Imatinib Resumption Alone in Patients With Unresectable Advanced Gastrointestinal Stromal Tumors (GIST) After Failure of Standard Treatmentstreatment2recruiting
NCT05009927
Efficiency of Imatinib Treatment After 10 Years of Treatment in Patients With Gastrointestinal Stromal Tumours (GIST) (Gist-Ten)treatment2recruiting
NCT01735955
Study to Allow Access to Nilotinib for Patients Who Are on Nilotinib Treatment in a Novartis-sponsored Studytreatment4completed