Proparacaine is a topical anesthetic used for ophthalmic practice. It is found in ophthalmic solutions at a concentration of 0.5% as the hydrochloride salt.
- Mechanism
- Curator reviewed
The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability through the lipid layer of the nerve cell membrane. Proparacaine may alter epithelial sodium channels through interaction with channel protein residues. This limitation prevents the fundamental change necessary for the generation of the action potential.
- Primary indication
- Used as a local (ophthalmic) anesthetic.Curator reviewed · 1 structured indication
- Formula / weight
- C16H26N2O3 · 294.3892 g/mol (avg)
- First approval
- Canada, 2015 · United States, 1973
- Also known as
- Proxymetacaine
- Brand names
Resolves to
KCLANYCVBBTKTO-UHFFFAOYSA-NSMILESCCCOC1=C(N)C=C(C=C1)C(=O)OCCN(CC)CCWhat you can answer from here — as of September 12, 2026
Which drugs share a target with Proparacaine, and which of those have an active Phase 3 trial?
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