Risedronic acid

Identification

Name
Risedronic acid
Accession Number
DB00884
Description

Alendronic acid is a third generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's diseaseLabel1,2. It functions by preventing resorption of boneLabel1.

Type
Small Molecule
Groups
Approved, Investigational
Structure
Thumb
Weight
Average: 283.1123
Monoisotopic: 283.001074735
Chemical Formula
C7H11NO7P2
Synonyms
  • Acide risédroniqe
  • Acido risedronico
  • Acidum risedronicum
  • Risedronate
  • Risedronic acid
  • Risedronsäure
External IDs
  • NE-58095

Pharmacology

Indication

Risedronic acid is indicated for the treatment of osteoperosis in men, treatment of Paget's disease, treatment and prevention of osteoperosis in postmenopausal women, and treatment and prevention of glucocorticoid-induced osteoperosisLabel.

Associated Conditions
Contraindications & Blackbox Warnings
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Pharmacodynamics

Risedronate is a pyridine-based bisphosphonate that inhibits bone resorption caused by osteoclastsLabel.

Mechanism of action

Risedronatic acid binds to bone hydroxyapatiteLabel. Bone resorption causes local acidification, releasing risedronic acid which is that taken into osteoclasts by fluid-phase endocytosis1. Endocytic vesicles are acidified, releasing risedronic acid to the cytosol of osteoclasts where they induce apoptosis through inhbition of farnesyl pyrophosphate synthase1. Inhibition of osteoclasts results in decreased bone resorption1.

TargetActionsOrganism
AFarnesyl pyrophosphate synthase
inhibitor
Humans
AHydroxylapatite
antagonist
Humans
Absorption

Oral bioavailability is 0.63% and maximum absorption is approximately 1 hour after dosingLabel. Administration half and hour before a meal reduces bioavailability by 55% compared to fasting and dosing 1 hour before a meal reduces bioavailability by 30%Label.

Volume of distribution

13.8 L/kgLabel.

Protein binding

~24%Label.

Metabolism

Risedronic acid is not likely not metabolized before eliminationLabel. The P-C-P group of bisphosphonates is resistant to chemical and enzymatic hydrolysis preventing metabolism of the molecule1.

Route of elimination

Risedronate is excreted by the kidneys and the unabsorbed dose is eliminated in the fecesLabel.

Half-life

The initial half life of risedronic acid is approximately 1.5 hours3, with a terminal half life of 561 hoursLabel.

Clearance

Mean renal clearance was 52mL/min and mean total clearance was 73mL/minLabel.

Adverse Effects
Learn about our commercial Adverse Effects data.
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Toxicity

In clinical trials, over 10% of patients experienced back pain, arthralgia, abdominal pain, and dyspepsiaLabel. Less commonly, patients experience angioedema, generalized rash, bullous skin reactions, iritis, and uveitisLabel.

Patients experiencing an overdose may experience a decrease in serum calcium and phosphorusLabel. Patients can be given milk or antacids to bind the drug and reduce its absorptionLabel. In more severe cases, patients may require gastric lavage and intravenous calciumLabel. A lethal dose in rats is equivalent to 320 to 620 times the human dose based on surface areaLabel.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Risedronate Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AceclofenacThe risk or severity of gastrointestinal bleeding can be increased when Aceclofenac is combined with Risedronic acid.
AcemetacinThe risk or severity of gastrointestinal bleeding can be increased when Acemetacin is combined with Risedronic acid.
Acetylsalicylic acidThe risk or severity of gastrointestinal bleeding can be increased when Acetylsalicylic acid is combined with Risedronic acid.
AcipimoxThe risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Risedronic acid is combined with Acipimox.
AcyclovirThe risk or severity of nephrotoxicity and hypocalcemia can be increased when Acyclovir is combined with Risedronic acid.
Adefovir dipivoxilThe risk or severity of nephrotoxicity and hypocalcemia can be increased when Adefovir dipivoxil is combined with Risedronic acid.
AlclofenacThe risk or severity of gastrointestinal bleeding can be increased when Alclofenac is combined with Risedronic acid.
Alendronic acidThe risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Alendronic acid is combined with Risedronic acid.
AlmasilateThe serum concentration of Risedronic acid can be decreased when it is combined with Almasilate.
AluminiumThe serum concentration of Risedronic acid can be decreased when it is combined with Aluminium.
Additional Data Available
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Food Interactions
  • Administer vitamin supplements. Patients may require supplemental vitamin D.
  • Avoid multivalent ions. Calcium, antacids, and divalent ions may interfere with the absorption of this medication.
  • Take on an empty stomach.
  • Take with a full glass of water.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Risedronate sodiumOFG5EXG60L115436-72-1DRFDPXKCEWYIAW-UHFFFAOYSA-M
Risedronate sodium hemi-pentahydrateHU2YAQ274O329003-65-8HYFDYHPNTXOPPO-UHFFFAOYSA-L
Risedronate sodium monohydrateF67L43UT5C353228-19-0KLQNARDFMJRXSF-UHFFFAOYSA-M
Product Images
International/Other Brands
Benet (Takeda ) / Ridron
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
ActonelTablet, film coated30 mg/1OralWarner Chilcott1998-03-27Not applicableUS flag
ActonelTablet35 mgOralAllergan2002-12-10Not applicableCanada flag
ActonelTablet, film coated150 mg/1OralWarner Chilcott2008-04-22Not applicableUS flag
ActonelTablet, film coated5 mg/1OralPhysicians Total Care, Inc.2002-03-15Not applicableUS flag
ActonelTablet5 mgOralAllergan Pharma Co.2000-07-252019-01-04Canada flag
ActonelTablet, film coated35 mg/1OralWarner Chilcott2002-05-17Not applicableUS flag
ActonelTablet75 mgOralWarner Chilcott2007-08-132016-08-05Canada flag
ActonelTablet, film coated150 mg/1OralPhysicians Total Care, Inc.2009-10-05Not applicableUS flag
ActonelTablet, film coated5 mg/1OralWarner Chilcott2000-04-14Not applicableUS flag
ActonelTablet150 mgOralAllergan2008-12-01Not applicableCanada flag
Additional Data Available
  • Application Number
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  • Product Code
    Product Code
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Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Apo-risedronateTabletOralApotex Corporation2012-05-17Not applicableCanada flag
Apo-risedronateTabletOralApotex Corporation2010-11-10Not applicableCanada flag
Auro-risedronateTabletOralAuro Pharma IncNot applicableNot applicableCanada flag
Auro-risedronateTabletOralAuro Pharma Inc2013-07-08Not applicableCanada flag
Auro-risedronateTabletOralAuro Pharma Inc2016-04-13Not applicableCanada flag
Auro-risedronateTabletOralAuro Pharma IncNot applicableNot applicableCanada flag
Dom-risedronateTabletOralDominion Pharmacal2011-04-19Not applicableCanada flag
Jamp-risedronateTabletOralJamp Pharma Corporation2011-10-04Not applicableCanada flag
Mylan-risedronateTabletOralMylan Pharmaceuticals2013-09-302017-08-02Canada flag
Mylan-risedronateTabletOralMylan Pharmaceuticals2011-06-162017-11-14Canada flag
Additional Data Available
  • Application Number
    Application Number
    Available for Purchase

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code
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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
ActonelRisedronate sodium hemi-pentahydrate (64.5 mg/1) + Risedronate sodium monohydrate (10.5 mg/1)Tablet, film coatedOralAllergan, Inc.2007-04-162010-03-31US flag
ActonelRisedronate sodium hemi-pentahydrate (30.1 mg/1) + Risedronate sodium monohydrate (4.9 mg/1)Tablet, film coatedOralAllergan, Inc.2002-05-17Not applicableUS flag00430 0472 03 nlmimage10 08400400
ActonelRisedronate sodium hemi-pentahydrate (4.3 mg/1) + Risedronate sodium monohydrate (0.7 mg/1)Tablet, film coatedOralAllergan, Inc.2000-04-142020-07-27US flag
ActonelRisedronate sodium hemi-pentahydrate (129 mg/1) + Risedronate sodium monohydrate (21 mg/1)Tablet, film coatedOralAllergan, Inc.2008-04-22Not applicableUS flag
ActonelRisedronate sodium hemi-pentahydrate (64.5 mg/1) + Risedronate sodium monohydrate (10.5 mg/1)Tablet, film coatedOralAllergan, Inc.2007-04-162010-03-31US flag
ActonelRisedronate sodium hemi-pentahydrate (25.8 mg/1) + Risedronate sodium monohydrate (4.2 mg/1)Tablet, film coatedOralAllergan, Inc.1998-03-272018-12-28US flag
ActonelRisedronate sodium hemi-pentahydrate (4.3 mg/1) + Risedronate sodium monohydrate (0.7 mg/1)Tablet, film coatedOralAllergan, Inc.2000-04-142020-07-27US flag
ActonelRisedronate sodium hemi-pentahydrate (129 mg/1) + Risedronate sodium monohydrate (21 mg/1)Tablet, film coatedOralAllergan, Inc.2008-04-22Not applicableUS flag
ActonelRisedronate sodium hemi-pentahydrate (30.1 mg/1) + Risedronate sodium monohydrate (4.9 mg/1)Tablet, film coatedOralAllergan, Inc.2002-05-17Not applicableUS flag00430 0472 03 nlmimage10 08400400
ActonelRisedronate sodium hemi-pentahydrate (25.8 mg/1) + Risedronate sodium monohydrate (4.2 mg/1)Tablet, film coatedOralAllergan, Inc.1998-03-272018-12-28US flag

Categories

ATC Codes
M05BB07 — Risedronic acid and colecalciferolM05BB02 — Risedronic acid and calcium, sequentialM05BB04 — Risedronic acid, calcium and colecalciferol, sequentialM05BA07 — Risedronic acid
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as bisphosphonates. These are organic compounds containing two phosphonate groups linked together through a carbon atoms.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Organic phosphonic acids and derivatives
Sub Class
Bisphosphonates
Direct Parent
Bisphosphonates
Alternative Parents
Pyridines and derivatives / Organic phosphonic acids / Heteroaromatic compounds / Azacyclic compounds / Organopnictogen compounds / Organophosphorus compounds / Organooxygen compounds / Organonitrogen compounds / Organic oxides / Hydrocarbon derivatives
Substituents
Aromatic heteromonocyclic compound / Azacycle / Bisphosphonate / Heteroaromatic compound / Hydrocarbon derivative / Organic nitrogen compound / Organic oxide / Organic oxygen compound / Organoheterocyclic compound / Organonitrogen compound
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
pyridines (CHEBI:8869)

Chemical Identifiers

UNII
KM2Z91756Z
CAS number
105462-24-6
InChI Key
IIDJRNMFWXDHID-UHFFFAOYSA-N
InChI
InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
IUPAC Name
[1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonic acid
SMILES
OC(CC1=CN=CC=C1)(P(O)(O)=O)P(O)(O)=O

References

Synthesis Reference

Srinivasa Rao V.N Divvela, Lenin Racha, Sivakumaran Meenakshisunderam, Ramesh Dandala, "Process for the preparation of risedronate sodium hemi-pentahydrate." U.S. Patent US20070173484, issued July 26, 2007.

US20070173484
General References
  1. Russell RG, Watts NB, Ebetino FH, Rogers MJ: Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos Int. 2008 Jun;19(6):733-59. doi: 10.1007/s00198-007-0540-8. [PubMed:18214569]
  2. Cremers S, Drake MT, Ebetino FH, Bilezikian JP, Russell RGG: Pharmacology of bisphosphonates. Br J Clin Pharmacol. 2019 Jun;85(6):1052-1062. doi: 10.1111/bcp.13867. Epub 2019 Feb 28. [PubMed:30650219]
  3. Thompson Micromedex (2004). Usp Vol I Drug Info Health Vol: Volume I (USP DI: v.1 Drug Information for the Health Care Professional) (24th ed., pp. 2475). Thompson PDR. [ISBN:1563634635]
  4. Risedronate Sodium Tablet MSDS [Link]
  5. FDA Approved Drugs: Risedronic Acid Oral Tablets [Link]
  6. FDA Approved Drug Products: Risedronic Acid Extended Release Tablets [Link]
Human Metabolome Database
HMDB0015022
KEGG Drug
D08484
KEGG Compound
C08233
PubChem Compound
5245
PubChem Substance
46507526
ChemSpider
5055
BindingDB
12576
RxNav
55685
ChEBI
8869
ChEMBL
CHEMBL923
ZINC
ZINC000001531009
Therapeutic Targets Database
DAP000658
PharmGKB
PA451255
PDBe Ligand
RIS
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
PDRhealth
PDRhealth Drug Page
Wikipedia
Risedronate
AHFS Codes
  • 92:24.00 — Bone Resorption Inhibitors
PDB Entries
1rqj / 1yhl / 1yq7 / 1yv5 / 2o1o / 2qis / 4kpd / 4kqs / 4n9u / 4ng6
show 6 more
FDA label
Download (229 KB)
MSDS
Download (69.7 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedNot AvailableCrohn's Disease (CD) / Low Bone Mineral Density1
4CompletedPreventionBone Loss / Breast Cancer / Osteoporosis1
4CompletedPreventionBone Loss / Epilepsies / Fracture Bone / Osteoporosis1
4CompletedPreventionCystic Fibrosis (CF) / Muscular Dystrophy / Osteoporosis1
4CompletedPreventionPostmenopausal Osteoporosis (PMO)1
4CompletedSupportive CareBariatric Surgery Candidate / Bone Loss / Weight Loss1
4CompletedTreatmentBone Loss1
4CompletedTreatmentBreast Cancer1
4CompletedTreatmentColles' Fracture1
4CompletedTreatmentOsteoporosis6

Pharmacoeconomics

Manufacturers
  • Warner chilcott co llc
  • Teva pharmaceuticals usa
  • Procter & Gamble
Packagers
  • Diversified Healthcare Services Inc.
  • Lake Erie Medical and Surgical Supply
  • Murfreesboro Pharmaceutical Nursing Supply
  • Norwich Pharmaceuticals Inc.
  • Physicians Total Care Inc.
  • Procter & Gamble
  • Resource Optimization and Innovation LLC
  • Stat Rx Usa
  • Warner Chilcott Co. Inc.
  • WC Pharmaceuticals
Dosage Forms
FormRouteStrength
Tablet, film coatedOral35 MG
Tablet, effervescent35 mg
TabletOral150 mg
TabletOral30 mg
TabletOral5 mg
TabletOral75 mg
Tablet, film coatedOral150 mg/1
Tablet, film coatedOral30 mg/1
Tablet, film coatedOral35 mg/1
Tablet, film coatedOral5 mg/1
Tablet, film coatedOral75 mg/1
Tablet, coatedOral150 mg
Tablet, delayed releaseOral35 MG
Tablet, film coatedOral30 MG
Tablet, film coatedOral5 MG
Tablet, film coatedOral75 MG
Tablet, delayed releaseOral
Tablet, film coatedOral
Granule, effervescent; kit; tabletOral
KitOral
Tablet, delayed releaseOral
Tablet, effervescent150 mg
Tablet, effervescent30 mg
Tablet, effervescent75 mg
Tablet, effervescentOral150 mg
TabletOral35 MG
Tablet, effervescentOral35 mg
TabletOral
TabletOral6 mg
Tablet, coatedOral35 MG
Tablet, delayed releaseOral35 mg/1
Tablet, film coatedOral
PowderNot applicable1 kg/1kg
Tablet, coatedOral30 MG
Tablet, coatedOral5 MG
Tablet, coatedOral75 MG
Tablet, effervescentOral75 mg
TabletOral
Kit; tabletOral
Prices
Unit descriptionCostUnit
Actonel 150 mg tablet125.1USD tablet
Actonel 4 35 mg tablet Disp Pack119.43USD disp
Actonel 75 mg tablet54.83USD tablet
Actonel 30 mg tablet29.32USD tablet
Actonel 35 mg tablet28.75USD tablet
Actonel 5 mg tablet4.13USD tablet
Actonel with calcium tablet3.92USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US6096342No2000-08-012011-11-22US flag
CA2294595No2001-08-212018-07-17Canada flag
CA2399976No2007-03-272021-02-01Canada flag
US7192938Yes2007-03-202023-11-06US flag
US7718634Yes2010-05-182023-11-06US flag
US6165513Yes2000-12-262018-12-10US flag
US5994329Yes1999-11-302019-01-17US flag
US6015801Yes2000-01-182019-01-17US flag
US6432932Yes2002-08-132019-01-17US flag
US6465443Yes2002-10-152019-02-14US flag
US7645459No2010-01-122028-01-09US flag
US7645460No2010-01-122028-01-09US flag
US8246989No2012-08-212026-01-16US flag
Additional Data Available
  • Filed On
    Filed On
    Available for Purchase

    The date on which a patent was filed with the relevant government.

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Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)252-262https://www.greenstonellc.com/sites/default/files/pdfs/MSDS/RISEDRONATE%20SODIUM%20TABLETS%20MSDS_0.pdf
boiling point (°C)692.3https://www.greenstonellc.com/sites/default/files/pdfs/MSDS/RISEDRONATE%20SODIUM%20TABLETS%20MSDS_0.pdf
Predicted Properties
PropertyValueSource
Water Solubility10.4 mg/mLALOGPS
logP-0.75ALOGPS
logP-3.3ChemAxon
logS-1.4ALOGPS
pKa (Strongest Acidic)0.68ChemAxon
pKa (Strongest Basic)4.91ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area148.18 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity57.12 m3·mol-1ChemAxon
Polarizability21.91 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
PropertyValueProbability
Human Intestinal Absorption-0.9357
Blood Brain Barrier+0.9172
Caco-2 permeable-0.6795
P-glycoprotein substrateNon-substrate0.6846
P-glycoprotein inhibitor INon-inhibitor0.9582
P-glycoprotein inhibitor IINon-inhibitor1.0
Renal organic cation transporterNon-inhibitor0.9542
CYP450 2C9 substrateNon-substrate0.8452
CYP450 2D6 substrateNon-substrate0.8162
CYP450 3A4 substrateNon-substrate0.7208
CYP450 1A2 substrateNon-inhibitor0.8778
CYP450 2C9 inhibitorNon-inhibitor0.8792
CYP450 2D6 inhibitorNon-inhibitor0.9062
CYP450 2C19 inhibitorNon-inhibitor0.8777
CYP450 3A4 inhibitorNon-inhibitor0.9068
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.989
Ames testNon AMES toxic0.7663
CarcinogenicityNon-carcinogens0.8386
BiodegradationNot ready biodegradable0.5058
Rat acute toxicity2.1053 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9095
hERG inhibition (predictor II)Non-inhibitor0.9303
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Inhibitor
General Function
Poly(a) rna binding
Specific Function
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids...
Gene Name
FDPS
Uniprot ID
P14324
Uniprot Name
Farnesyl pyrophosphate synthase
Molecular Weight
48275.03 Da
References
  1. Bergstrom JD, Bostedor RG, Masarachia PJ, Reszka AA, Rodan G: Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. Arch Biochem Biophys. 2000 Jan 1;373(1):231-41. [PubMed:10620343]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  3. Coxon FP, Ebetino FH, Mules EH, Seabra MC, McKenna CE, Rogers MJ: Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo. Bone. 2005 Sep;37(3):349-58. [PubMed:16006204]
  4. Dunford JE, Thompson K, Coxon FP, Luckman SP, Hahn FM, Poulter CD, Ebetino FH, Rogers MJ: Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther. 2001 Feb;296(2):235-42. [PubMed:11160603]
  5. Ortiz-Gomez A, Jimenez C, Estevez AM, Carrero-Lerida J, Ruiz-Perez LM, Gonzalez-Pacanowska D: Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate. Eukaryot Cell. 2006 Jul;5(7):1057-64. [PubMed:16835450]
  6. Russell RG, Xia Z, Dunford JE, Oppermann U, Kwaasi A, Hulley PA, Kavanagh KL, Triffitt JT, Lundy MW, Phipps RJ, Barnett BL, Coxon FP, Rogers MJ, Watts NB, Ebetino FH: Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy. Ann N Y Acad Sci. 2007 Nov;1117:209-57. [PubMed:18056045]
Kind
Small molecule
Organism
Humans
Pharmacological action
Yes
Actions
Antagonist
References
  1. Jahnke W, Henry C: An in vitro assay to measure targeted drug delivery to bone mineral. ChemMedChem. 2010 May 3;5(5):770-6. doi: 10.1002/cmdc.201000016. [PubMed:20209564]
  2. Nancollas GH, Tang R, Phipps RJ, Henneman Z, Gulde S, Wu W, Mangood A, Russell RG, Ebetino FH: Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite. Bone. 2006 May;38(5):617-27. Epub 2005 Jul 20. [PubMed:16046206]

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Prostaglandin-endoperoxide synthase activity
Specific Function
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and...
Gene Name
PTGS2
Uniprot ID
P35354
Uniprot Name
Prostaglandin G/H synthase 2
Molecular Weight
68995.625 Da
References
  1. Valenti MT, Giannini S, Donatelli L, Zanatta M, Bertoldo F, Sella S, Vilei MT, Ossi E, Realdi G, Lo Cascio V, Dalle Carbonare L: The effect of risedronate on osteogenic lineage is mediated by cyclooxygenase-2 gene upregulation. Arthritis Res Ther. 2010;12(4):R163. doi: 10.1186/ar3122. Epub 2010 Aug 25. [PubMed:20738860]

Drug created on June 13, 2005 07:24 / Updated on November 23, 2020 12:18

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