Farnesyl pyrophosphate synthase

BE0000776ProteinHumansFDPS

Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. It is acted on by 24 drugs in DrugBank.

Gene name
FDPS
UniProtKB entry
P14324Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
419 residues · 48,275 Da
Also known as
(2E,6E)-farnesyl diphosphate synthase · 2.5.1.10 · Dimethylallyltranstransferase · Farnesyl diphosphate synthase · FPP synthase

Resolves to

Protein
UniProtP14324UniProt nameFPPS_HUMAN
Gene
HGNCHGNC:3631NCBI Gene2224GenBank182399GeneCardsFDPS
Pharmacology
IUPHAR/GtoPdb644KEGGhsa:2224
Structure
PDB1YQ7PDB1YV5PDB1ZW5
Drugs

What you can answer from here — as of September 07, 2019

24DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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113+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Farnesyl pyrophosphate synthase, how selective are they, and which programs against it are still in active trials?

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