Oxybuprocaine is a local anesthetic used in ophthalmology. Oxybuprocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions.
- Mechanism
- Curator reviewed
Oxybuprocaine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.
- Primary indication
- Used to temporarily numb the front surface of the eye so that the eye pressure can be measured or a foreign body removed.Curator reviewed · 7 structured indications
- Formula / weight
- C17H28N2O3 · 308.4158 g/mol (avg)
- First approval
- Canada, 1998 · United States, 2017
- Also known as
- Benoxinate · Oxybucaine · Oxyriprocaine
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
CMHHMUWAYWTMGS-UHFFFAOYSA-NSMILESCCCCOC1=CC(=CC=C1N)C(=O)OCCN(CC)CCTargets
What you can answer from here — as of September 12, 2026
2Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Oxybuprocaine, and which of those have an active Phase 3 trial?
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